Formulation and optimization of mucoadhesive buccal patches of losartan potassium by using response surface methodology

Ikram, M. S.; Gilhotra, Neeraj; Gilhotra, Ritu

doi:10.4103/2277-9175.168606

Cited by 17 publications

(4 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Using HPMC-K100M, SCMC, PVP-K30, and CP934, the bilayer gel-based systems were created through direct compression [ 17 , 18 ]. Because of its minimal water permeability and its flexibility in the buccal environment, EC was chosen as the backing layer [ 19 ]. The HPMC, SCMC, and CP form a gel coating over the nifedipine nucleus.…”

Section: Resultsmentioning

confidence: 99%

Development and Characterization of Gel-Based Buccoadhesive Bilayer Formulation of Nifedipine

Alagusundaram,

Jain,

Begum

et al. 2023

Gels

View full text Add to dashboard Cite

A promising controlled drug delivery system has been developed based on polymeric buccoadhesive bilayered formulation that uses a drug-free backing layer and a polymeric hydrophilic gel buccoadhesive core layer containing nifedipine. The DSC thermogravimetric analysis confirms the drug’s entrapment in the gel layer and reveals no evidence of a potential interaction. Various ratios of bioadhesive polymers, including HPMC K100, PVP K30, SCMC, and CP 934, were combined with EC as an impermeable backing layer to ensure unidirectional drug release towards the buccal mucosa. The polymeric compositions of hydrophilic gel-natured HPMC, SCMC, and CP formed a matrix layer by surrounding the core nifedipine during compression. Preformulation studies were performed for all of the ingredients in order to evaluate their physical and flow characteristics. Ex vivo buccoadhesive strength, surface pH, swelling index, in vitro and in vivo drug release, and ex vivo permeation investigations were performed to evaluate the produced gel-based system. Rapid temperature variations had no appreciable impact on the substance’s physical properties, pharmacological content, or buccoadhesive strength during stability testing using actual human saliva. It was clear from a histological examination of the ex vivo mucosa that the developed system did not cause any irritation or inflammation at the site of administration. The formulation NT5 was the best one, with a correlation coefficient of 0.9966. The in vitro and in vivo drug release profiles were well correlated, and they mimic the in vitro drug release pattern via the biological membrane. Thus, the developed gel-based formulation was found to be novel, stable, and useful for the targeted delivery of nifedipine.

show abstract

Section: Resultsmentioning

confidence: 99%

Development and Characterization of Gel-Based Buccoadhesive Bilayer Formulation of Nifedipine

Alagusundaram,

Jain,

Begum

et al. 2023

Gels

View full text Add to dashboard Cite

show abstract

“…The top two hundred micrometers of skin serve as this barrier 11 . Researchers use tracers with extremely high molecular weights, such as horseradish peroxidase and lanthanum nitrate, to study permeation.…”

Section: Permeabilitymentioning

confidence: 99%

Untitled

2023

IJPSR

View full text Add to dashboard Cite

To increase patient compliance, safety, and effectiveness, the need for the design and development of a new dosage form has arisen. Novel film technology like buccal film meets all these needs. The buccal film is inserted into the mouth and the medicine is then absorbed via the buccal mucosa. Compared to alternative buccal drug delivery systems such as wafers, lozenges, microparticles, gel and tablets, buccal film is a more appealing and acceptable dosage form due to its small size, dose and ease of administration. Because it avoids first-pass digestion, buccal film is a very efficient dose form that significantly boosts bioavailability. It is more practical than other forms of dosing because it sticks well to the buccal mucosa of the mouth. Not ingesting the medicine is necessary; it is non-irritating and cost-efficient; other benefits include its sleek design, ease of use and biodegradability. Therefore, this dose type is preferred by both elderly and young patients. This review focuses on buccoadhesive drug delivery methods, which are reliant on adhering to mucuscoated biological surfaces. There is now a need for further investigation on topics like patient convenience and compliance. This article thoroughly analyzes buccal film, including its uses, drawbacks and advantages, methods of production, assessment criteria and formulation.

show abstract

“…The microcapsules formed were separated, washed using distilled water later dried at ambient temperature for 24 hr. 9,10,11,12 Formula for Mucoadhesive microcapsule formulation is given in Table 1.…”

Section: S245mentioning

confidence: 99%

Formulation and Characterization Sustained Release Mucoadhesive Microcapsule of Baclofen

Bhambar,

Gadakh

2023

Ind. J. Pharm. Edu. Res

View full text Add to dashboard Cite

Background: Baclofen is used as skeletal muscle relaxant. Baclofen inhibit Polysynaptic and monosynaptic reflexes a hyperpolarisation. Baclofen drug absorbed rapidly and excreted in feces urine in unchanged form. Objectives: Aim of the current study was to formulate sustained release mucoadhesive microcapsules of Baclofen using different polymers like Chitosan, Carbopol934P, HPMC K4M. Materials and Methods: Ionotropic gelation method was used for preparation of microcapsules of baclofen. Dispersion of polymers and baclofen was dropwise added sodium tripolyphosphate solution to form microcapsule. The prepared microcapsules were evaluated for FTIR studies, micromeritic properties, drug entrapment efficiency, particle size and shape, SEM, swelling index, mucoadhesive strength, in vitro release studies. Results: Angle of repose of prepared microcapsules was in range 24.48 ± 1.39 to 38.08±1.67 showed good flowability. Prepared microcapsules showed bulk density in the range of 0.49±0.04 to1.22±0.06. All formulations showed Carr's index and Hausner's ratio in the range of 14.68 ±1.20 to 29.56 ± 1.97 and 1.16±0.012 to 1.25±0.016 respectively. Formulation F1 to F3 prepared with HPMC (K4M) showed drug release 77.78%, 74.94%, 77.99% and formulation F4 to F6 prepared with Carbopol 934P showed drug release 78.20%, 79.05%, 87.48% respectively in 12hr. Conclusion: Sustained release profile F6 formulation was obtained due to significant mucoadhesive efficiency of the Carbopol 934P. Hence the mucoadhesive microcapsules of Baclofen would be an effective strategy for the management of Muscle Pain.

show abstract

Formulation and optimization of mucoadhesive buccal patches of losartan potassium by using response surface methodology

Cited by 17 publications

References 29 publications

Development and Characterization of Gel-Based Buccoadhesive Bilayer Formulation of Nifedipine

Development and Characterization of Gel-Based Buccoadhesive Bilayer Formulation of Nifedipine

Untitled

Formulation and Characterization Sustained Release Mucoadhesive Microcapsule of Baclofen

Contact Info

Product

Resources

About