Formulation and stability of topical water in oil emulsion containing corn silk extract

Mohsin, Sabeeh; Akhtar, Naveed; Mahmood, Tariq; Khan, Hira; Mustafa, Rehan

doi:10.4314/tjpr.v15i6.1

Cited by 23 publications

(15 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Such characteristic is desired for topical use of pharmaceutical and cosmetic products. Pseudoplastic can be expected to exhibit better spreadability (Mohsin et al, 2016). The spreadability of the preparation appropriate with optimal value for semisolid preparation is 5-7 cm (Garg et al, 2002).…”

Section: Resultsmentioning

confidence: 99%

In-vitro diffusion study of caffeine from microemulsion gel system containing grape seed oil

Priani

Wulansari

Darusman³

2021

Pharmaciana

View full text Add to dashboard Cite

Cellulite was identified by the orange-peel appearance of skin surface that presents in 80-90% of post-pubertal women. Caffeine and grape seed oil were known can be used as an anticellulite agent. Microemulsion systems are known could enhance the diffusion rate of drugs through the skin. This study was conducted to develop a microemulsion gel containing caffeine and grape seed oil and determine the effect of caffeine's in vitro diffusion profile. Microemulsion gel was prepared using tween 80 as a surfactant, glycerin as cosurfactant, viscolam mac 10 as a gelling agent. The preparations were evaluated by organoleptic, pH, viscosity, rheology, spreadability, globule size, and thermodynamic stability tests. In vitro diffusion tests were performed by Franz diffusion cell. The result showed that microemulsion containing 1 % of caffeine and 5% of grapeseed oil has good physical characteristics and stability with an average globule size 126 ±17 nm. Microemulsion gel system could enhance the cumulative release amount of caffeine through synthetic membrane compared with gel system. Drug release kinetics of caffeine from microemulsion gel system follows the Higuchi model.

show abstract

Section: Resultsmentioning

confidence: 99%

In-vitro diffusion study of caffeine from microemulsion gel system containing grape seed oil

Priani

Wulansari

Darusman³

2021

Pharmaciana

View full text Add to dashboard Cite

show abstract

“…Macro et al [28] documented that the EI of an emulsifying agent can be used to predict its stability potential in the emulsion. Hence, the closer the EI value is to 1, the higher the stabilization potential of the emulsifying agent [29]. The EI were observed to increase with increase in the concentration of the emulsifying agents (Tween 80 ® and ACS), however, emulsions containing ACS had higher EI values when compared with emulsions containing Tween 80 ® .…”

Section: Globule Size and Shape And Emulsion Indexmentioning

confidence: 93%

Stabilization potential of acidified corn starch in vitamin E enriched coconut oil emulsions for extemporaneous topical formulations

Adetunji¹,

Akingbade²

2021

J. Pharm Bio.

View full text Add to dashboard Cite

In this study, the stabilizing potential of corn starch acidified with hydrochloric acid (ACS) in comparison with Tween 80® was evaluated in vitamin E enriched coconut emulsions for use in extemporaneous topical formulations. Emulsions containing vitamin E and coconut oil (2:3) as lipid phase and different concentrations (1.5 – 5.0 %w/w) of ACS (or Tween80®) in phosphate buffer as aqueous phase were formulated at 27± 2 ⁰C. , Droplet sizes and shapes, pH and rheological properties were evaluated. Acidified CS was analysed using FTIR spectroscopy Emulsions stabilized with ACS and Tween80® were cream and yellow coloured respectively, with the intensity of the colour increasing as the concentration increased. The emulsions were non-offensive and easily re-dispersed on shaking. Emulsions containing ACS had larger droplet sizes (18.34± 1.14 - 33.27± 1.32 µm) and were more spherically shaped with higher pH values(6.80-6.95), showing dilatant and pseudoplastic flows at low and high shear rates respectively. The viscosity of emulsions stabilized at 2.5 %w/w and 5.0 %w/w remained unchanged after seven days. Acidified corn starch has stabilizing potentials comparable with Tween 80® when incorporated in vitamin E enriched coconut oil emulsions for extemporaneous topical formulations. Keywords: Coconut oil emulsions; Vitamin E; Acidified corn starch; Tween80®; Viscosity Emulsion stability, Extemporaneous topical formulations

show abstract

“…The change in color from purple to yellow is estimated by measuring reduction in absorbance at 517 nm. The DPPH radical scavenging activity was determined using a previously described method, but with some modifications [14]. Ninety microliters (90 µL) of 100 µM DPPH solution prepared in methanol was added to 10 µL of test sample to make a final volume of 100 µL in a 96-well microliter plate.…”

Section: 2-diphenyl-1-picryl Hydrazyl (Dpph) Radical Scavenging Assaymentioning

confidence: 99%

Determination of sun protection factor and physical remanence of dermocosmetic emulgels formulated with Manilkara zapota (L.) fruit extract

Kashif¹,

Akhtar²

2021

Trop. J. Pharm Res

Self Cite

View full text Add to dashboard Cite

Purpose: To develop a stable emulgel formulation from Manilkara zapota fruit extract (MZFE) and evaluate its sun-protective factor (SPF) and its physical retention on facial skin. Methods: Active test formulations containing MZFE and placebo (containing no active ingredients) were prepared by dispersing the primary emulsion into a gel phase. Both test and placebo emulgel formulations were subjected to physicochemical evaluation, stability studies, and assessment of possible photo-protective properties. The sun-protective factor (SPF) was determined in vitro by spectrophotometric analysis. Non-invasive in vivo skin bioengineering technique was used to assess the UV-quenching effects of the test and placebo emulgel formulations. Results: A stable and cosmetically acceptable emulgel formulation loaded with MZFE was obtained. The formulation and control exhibited optimum physicochemical stability in stress stability tests. The formulation exhibited promising photo-protective effects both in vitro (SPF = 14.215 ± 0.140) and in vivo (lasted for approximately 120 min). Conclusion: The developed MZFE-loaded test emulgel formulation possesses suitable photoprotection capability in vitro, and displays quenching effects against specific wavelengths of UV light, indicating a UV-filtering property

show abstract

Formulation and stability of topical water in oil emulsion containing corn silk extract

Abstract: Purpose: To formulate the water in oil (W/O) emulsion of corn silk (CS) extract and to evaluate its

Cited by 23 publications

References 21 publications

In-vitro diffusion study of caffeine from microemulsion gel system containing grape seed oil

In-vitro diffusion study of caffeine from microemulsion gel system containing grape seed oil

Stabilization potential of acidified corn starch in vitamin E enriched coconut oil emulsions for extemporaneous topical formulations

Determination of sun protection factor and physical remanence of dermocosmetic emulgels formulated with Manilkara zapota (L.) fruit extract

Contact Info

Product

Resources

About