Formulation-dependent stability mechanisms affecting dissolution performance of directly compressed griseofulvin tablets

Bromelain: a review of its mechanisms, pharmacological effects and potential applications

“…170 These materials can affect the stability of the formulation as well as the efficacy, bioavailability and safety of bromelain. 171 The activity of bromelain might be potentiated by certain substances, while others might prove toxic or immunogenic. In order to select the most suitable nanomaterial for bromelain, various materials need to be screened and evaluated.…”

Assessment of Directional–Hemispherical Reflectance of Tablets with Cefuroxime during Storage under Elevated Temperature and Ultraviolet Radiation

“…The authors found that the highest mean temperature was in the living room or hallway, with maxima of 27.1 °C and 33.9 °C, respectively [ 17 ]. In turn, McLean et al [ 18 ] stored griseofulvin tablets in different temperatures of 37 °C, 50 °C, and 60 °C for 1, 2, or 4 weeks to analyze the dissolution performance after storage. However, in studies analyzing problems with drug storage, light exposure is usually not measured and the temperature, e.g., in front of the window is always higher compared to other places.…”

At-line porosity sensing for non-destructive disintegration testing in immediate release tablets

“…Depending on the drug's and excipients' chemical and physical stability, the disintegration mechanism can change during storage. These changes have generally been ascribed to moisture sorption and hygroscopicity of the used excipients, which may lead to changes in porosity, tensile strength, and contact angle ( Maclean et al, 2022 , Maclean et al, 2023 ). A reduction in the disintegration time due to gel formation, partial dissolution and recrystallisation of soluble fillers (i.e., with high hygroscopicity) upon exposure to high humidity levels have been reported previously ( Gordon et al, 1993 ).…”