Formulation design for inkjet-based 3D printed tablets

Sen, Koyel; Manchanda, Arushi; Mehta, Tanu; Anson, W. K.; Chaudhuri, Bodhisattwa

doi:10.1016/j.ijpharm.2020.119430

Cited by 59 publications

(30 citation statements)

References 17 publications

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“…Therefore, these data can be used as a reference point for the preparation of 3D printed immediate release tablets. The BJ technique was also used in another study in which immediate-release tablets of amitryptiline hydrochloride were prepared [77]. The innovation of this study was to achieve effective and precise drug loading, even at the microscale, by incorporating the drug into the ink rather than adding it to the powder mixture.…”

Section: Excipientsmentioning

confidence: 99%

3D-Printed Oral Dosage Forms: Mechanical Properties, Computational Approaches and Applications

et al. 2021

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The aim of this review is to present the factors influencing the mechanical properties of 3D-printed oral dosage forms. It also explores how it is possible to use specific excipients and printing parameters to maintain the structural integrity of printed drug products while meeting the needs of patients. Three-dimensional (3D) printing is an emerging manufacturing technology that is gaining acceptance in the pharmaceutical industry to overcome traditional mass production and move toward personalized pharmacotherapy. After continuous research over the last thirty years, 3D printing now offers numerous opportunities to personalize oral dosage forms in terms of size, shape, release profile, or dose modification. However, there is still a long way to go before 3D printing is integrated into clinical practice. 3D printing techniques follow a different process than traditional oral dosage from manufacturing methods. Currently, there are no specific guidelines for the hardness and friability of 3D printed solid oral dosage forms. Therefore, new regulatory frameworks for 3D-printed oral dosage forms should be established to ensure that they meet all appropriate quality standards. The evaluation of mechanical properties of solid dosage forms is an integral part of quality control, as tablets must withstand mechanical stresses during manufacturing processes, transportation, and drug distribution as well as rough handling by the end user. Until now, this has been achieved through extensive pre- and post-processing testing, which is often time-consuming. However, computational methods combined with 3D printing technology can open up a new avenue for the design and construction of 3D tablets, enabling the fabrication of structures with complex microstructures and desired mechanical properties. In this context, the emerging role of computational methods and artificial intelligence techniques is highlighted.

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Section: Excipientsmentioning

confidence: 99%

3D-Printed Oral Dosage Forms: Mechanical Properties, Computational Approaches and Applications

et al. 2021

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“…The 3D printing methods can operate with a powder, which is bound with a liquid binder or sintered with a laser, a photosensitive resin, a thermoplastic material, or a semi-solid formulation extruded through the printer nozzle. Several techniques, such as stereolithography [10][11][12][13][14], selective laser sintering [8,15] digital light processing [16,17], binder jetting, [18,19], and extrusion-based methods including direct powder extrusion [20,21], semi-solid extrusion [22][23][24][25][26], and fused deposition modeling (FDM) [27,28], have been investigated for application in the pharmaceutical industry. The 3DP methods which can be introduced in the high-scale manufacturing process should be characterized by the high-speed production of uniform objects [29,30].…”

Section: Introductionmentioning

confidence: 99%

Multivariate Design of 3D Printed Immediate-Release Tablets with Liquid Crystal-Forming Drug—Itraconazole

et al. 2020

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The simplicity of object shape and composition modification make additive manufacturing a great option for customized dosage form production. To achieve this goal, the correlation between structural and functional attributes of the printed objects needs to be analyzed. So far, it has not been deeply investigated in 3D printing-related papers. The aim of our study was to modify the functionalities of printed tablets containing liquid crystal-forming drug itraconazole by introducing polyvinylpyrrolidone-based polymers into the filament-forming matrices composed predominantly of poly(vinyl alcohol). The effect of the molecular reorganization of the drug and improved tablets’ disintegration was analyzed in terms of itraconazole dissolution. Micro-computed tomography was applied to analyze how the design of a printed object (in this case, a degree of an infill) affects its reproducibility during printing. It was also used to analyze the structure of the printed dosage forms. The results indicated that the improved disintegration obtained due to the use of Kollidon®CL-M was more beneficial for the dissolution of itraconazole than the molecular rearrangement and liquid crystal phase transitions. The lower infill density favored faster dissolution of the drug from printed tablets. However, it negatively affected the reproducibility of the 3D printed object.

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“…Instead, in the unprinted regions, the drug particles maintained their original shapes, showing cracks and fissures [ 34 ]. Additionally, in the work done by Sen et al, the SEM analysis was performed, and it was reported an external rough structure of the tablets, with numerous porous gaps or voids on the surface [ 35 ].…”

Section: Resultsmentioning

confidence: 99%

3DP Printing of Oral Solid Formulations: A Systematic Review

et al. 2021

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Three-dimensional (3D) printing is a recent technology, which gives the possibility to manufacture personalised dosage forms and it has a broad range of applications. One of the most developed, it is the manufacture of oral solid dosage and the four 3DP techniques which have been more used for their manufacture are FDM, inkjet 3DP, SLA and SLS. This systematic review is carried out to statistically analyze the current 3DP techniques employed in manufacturing oral solid formulations and assess the recent trends of this new technology. The work has been organised into four steps, (1) screening of the articles, definition of the inclusion and exclusion criteria and classification of the articles in the two main groups (included/excluded); (2) quantification and characterisation of the included articles; (3) evaluation of the validity of data and data extraction process; (4) data analysis, discussion, and conclusion to define which technique offers the best properties to be applied in the manufacture of oral solid formulations. It has been observed that with SLS 3DP technique, all the characterisation tests required by the BP (drug content, drug dissolution profile, hardness, friability, disintegration time and uniformity of weight) have been performed in the majority of articles, except for the friability test. However, it is not possible to define which of the four 3DP techniques is the most suitable for the manufacture of oral solid formulations, because the selection is affected by different parameters, such as the type of formulation, the physical-mechanical properties to achieve. Moreover, each technique has its specific advantages and disadvantages, such as for FDM the biggest challenge is the degradation of the drug, due to high printing temperature process or for SLA is the toxicity of the carcinogenic risk of the photopolymerising material.

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Formulation design for inkjet-based 3D printed tablets

Cited by 59 publications

References 17 publications

3D-Printed Oral Dosage Forms: Mechanical Properties, Computational Approaches and Applications

3D-Printed Oral Dosage Forms: Mechanical Properties, Computational Approaches and Applications

Multivariate Design of 3D Printed Immediate-Release Tablets with Liquid Crystal-Forming Drug—Itraconazole

3DP Printing of Oral Solid Formulations: A Systematic Review

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