Formulation Design for Poorly Water-Soluble Drug by Using Solid Dispersion of Telmisartan for Solubility and Dissolution Rate Enhancement

Abstract

Formulating the drug into solid dispersion (SD) by fusion method and solvent evaporation method using different grades of PEG in comparison to plain telmisartan drug with optimised solid dispersion tablets. The Preformulation studies like FTIR and DSC studies for drug excipient compatibility stated that the drug and carrier selected for the study and are compatible for further studies. SD was prepared by using the drug Telmisartan by two methods, fusion method and solvent evaporation method, eighteen formulations were prepared and characterized in terms of various parameters. The in vitro drug for all the formulations were in the range of 82.38%-95.73% for fusion method and 91.45% to 96.81% for solvent evaporation method and tablets it ranges from 95.70% to 99.40%. The in-vitro release studies have shown that the cumulative drug release values were within the range of 14.23%-94.54% for fusion method, 18.57%- 95.89% for solvent evaporation method and 14.35% - 99.53% for tablets. The fast drug release about 99.53% was found in the F22 formulation by solvent evaporation method in solid dispersion tablets in the ratio of 1:2 and drug content was found to be 99.53% and disintegration time was 1.09 seconds and all parameters were found to be greater than all other formulations.