Formulation design preparation and in vitro characterization of nebivolol transdermal patches

Nayak, BhabaniShankar; Pattanayak, Dharmajit; Ellaiah, P; Das, Saumya

doi:10.4103/0973-8398.91994

Cited by 20 publications

(16 citation statements)

References 9 publications

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“…Strips were evenly cut and were evaluated by folding the film many times on the same spot till it broke. The folding endurance value was calculated by noting down the number of times it can be folded at the same spot without being broken/cracked [15].…”

Section: Folding Endurancementioning

confidence: 99%

Preparation and Evaluation of Simvastatin Transdermal Film

et al. 2018

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Objective: The objective of the study was to prepare simvastatin transdermal films for the treatment of atherosclerosis and to evaluate the effect of concentration of polymer on penetration enhancement.Methods: Solvent evaporation technique was employed for the preparation of films and the prepared films were evaluated for various physicochemical properties of films such as tensile strength, thickness, surface pH, swellability, drug content, moisture content and folding endurance. In vitro drug, release study and release kinetics were also studied.Results: Tensile strength ranged from 3.56±0.343 to 4.56±0.12 (N/mm²). The films were of uniform weight. Thickness varied from 0.2±0.3 mm to 0.2±0.8 mm. Surface pH ranged from 6.6±0.14 to 6.9±0.16. Percentage swellability ranged from12.1±0.36 to 16.3±0.22. Percentage drug content ranged from 88.4±0.7% to 90.5±0.6% in all the formulation. Percentage moisture content ranged from 0.864 to 1.03%. Moisture uptake was from 2.6±0.24 to 2.9±0.072. The folding endurance test gave satisfactory results and F3 formulation showed maximum drug release.Conclusion: From the study, it was concluded that out of various formulations, the F3 formulation was found to be the optimum formulation with 88% drug release at the fourteenth hour.Keywords: Simvastatin, Transdermal film, Solvent evaporation, Penetration enhancer, Swellability

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Section: Folding Endurancementioning

confidence: 99%

Preparation and Evaluation of Simvastatin Transdermal Film

et al. 2018

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“…Matrix type NFDPTFs were prepared by solvent evaporation technique 8 using different ratios of HPMC E15 and Eudragit L100. The polymers were weighed in requisite ratios and allowed for swelling for about 6 h in solvent mixture (1:1 ratio of methanol and chloroform) and 15% v/w Polyethylene glycol was incorporated as plasticizer.…”

Section: Preparation Of Nfdptfsmentioning

confidence: 99%

Preparation of Transdermal Films of Nifedipine: Ex-vivo and In-vitro Studies

Venkateswarlu¹,

Babu²,

Triveni³

et al. 2017

PHME

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Objective: The aim of present study was to prepare and evaluate the transdermal films (TFs) of Nifedipine (NFDP). Methods: The TFs were prepared by solvent evaporation technique and twelve formulations of NFDPTFs were prepared by taking HPMC E15 and Eudragit L100 in different ratios. Polyethylene glycol (15%) and Dimethyl sulfoxide (DMSO) were incorporated as plasticizer and permeation enhancer respectively. DMSO was incorporated in the formulations F7-F12 but it was absent in F1-F6. Results: The prepared TFs were evaluated for weight variation, thickness, folding endurance, drug content, moisture absorption, moisture content determination, mechanical properties and ex-vivo permeation. Mechanical properties revealed that the formulations F4 and F10 were found to be strong enough but not brittle. Hence, the formulations F4 and F10 were selected for ex-vivo studies. The formulations F4 and F10 showed maximum drug permeation within 24 h and formulation with permeation enhancer showed highest drug permeation than formulation without permeation enhancer. Conclusion: It could be concluded that the formulation with permeation enhancer (F10) showed highest permeability through the rat skin than formulation without permeation enhancer.

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“…The prepared patches were weighed and kept in desiccator containing activated silica at room temperature for 24 h. The individual patches were weighed on every alternate day until a constant weight was achieved. The percentage of moisture content was calculated by determining the difference between initial and final weight with respect to final weight [23][24][25]. Moisture Content (%) = W 1 -W 2 / W 2 × 100 Where, W 1 = Initial weight of each patch and W 2 = Final weight of each patch Moisture Uptake Nateglinide Transdermal patches were weighed and placed in desiccators containing a saturated solution of sodium chloride at 74% relative humidity (RH).…”

Section: Percentage Of Moisture Contentmentioning

confidence: 99%

Formulation and Evaluation of Nateglinide Patches for Transdermal Drug Delivery.

Solunke¹,

Chaudhari²

2017

JCPR

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Transdermal drug delivery is an alternative route for systemic drug delivery which minimizes the absorption and increases the bioavailability. Nateglinide is an Anti-Diabetic drug with a shorter half life, low bioavailability up to 72 % undergoes extensive first pass metabolism are required to maintain the therapeutic level it has chosen as transdermal drug delivery system. The present study was to formulate and evaluate transdermal drug delivery system of Nateglinide using polymers such as HPMC & Eudragit RL100 by solvent casting technique. The prepared formulations were evaluated for different physicochemical characteristics like Weight Variation, Folding Endurance, Flatness, pH of patches, % Moisture Content, % Moisture uptake, % Elongation, % Drug Content & % Drug Release. The drug release characteristics of the formulation were studied in-vitro by using semi-permeable membrane. The in-vitro drug release plot has shown that the drug release followed zero order kinetics & Higuchi model, which was evidenced from the regression values. Based on the drug release and physicochemical values obtained from the formulation F 7 is considered as an optimized formulation which shows higher percentage of drug release (96.27±0.68 % at 14 hour) with diffusion mediated mechanism. Korsmeyer-Peppas exponential plots shows fairly linear & it is well supported by their regression coefficients values & slope value (n) were >1 which suggest that drug was released by Super Case-II transport.

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Formulation design preparation and in vitro characterization of nebivolol transdermal patches

Cited by 20 publications

References 9 publications

Preparation and Evaluation of Simvastatin Transdermal Film

Preparation and Evaluation of Simvastatin Transdermal Film

Preparation of Transdermal Films of Nifedipine: Ex-vivo and In-vitro Studies

Formulation and Evaluation of Nateglinide Patches for Transdermal Drug Delivery.

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