Formulation development and evaluation of Transferosomal drug delivery for effective treatment of acne

Shah, Jay; Khan, Anwar Iqbal; Maurya, Rahul; Shukla, Ajay Kumar

doi:10.31024/apj.2019.4.1.4

Cited by 4 publications

(3 citation statements)

References 7 publications

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“…After centrifugation, 1 milliliter of the resulting supernatant was mixed with 9 milliliters of phosphate saline buffer (pH 7.4). [18,24] Subsequently, the diluted solution's absorbance was gauged at a wavelength of 254 nm using a UV-Vis spectrophotometer (Shimadzu-1900i).…”

Section: Drug Entrapment Efficiency and Its Calculationmentioning

confidence: 99%

“…The formulation and optimization of the transferosomes and hydrogel will be carried out; key parameters such as particle size, spreadability, pH, and entrapment efficiency [14][15][16][17]. The effectiveness and safety of the resultant nano biocomposite topical formulation will be thoroughly assessed via both in vitro and in vivo investigations [18][19][20]. To assess the stability of the formulation, a comprehensive stability study was conducted under accelerated and long-term storage conditions.…”

Section: Introductionmentioning

confidence: 99%

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Development and Evaluation of Nanobiocomposite Topical Formulation

JADAV,

PATEL,

LATA JHA

2024

Int J App Pharm

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Objective: The proposed research involving transferosomes within a hydrogel matrix offers a promising approach for enhanced wound healing. This system aims to facilitate the dermal delivery of nanosized curcumin while incorporating Ascorbic acid and Salicylic acid. The integration of these components holds the potential for advancing chronic wound therapy. Methods: Curcumin transferosomes were formulated by the lipid thin film hydration method and further optimization was carried out using 32 full factorial design. The transferosome formulation, prepared using phospholipon 90G, involved selecting specific variables: the quantity of edge activator and sonication duration as independent factors, while the optimization process considered particle size and entrapment efficiency as dependent variables. Following the optimization of the transferosomes, a hydrogel formulation was developed using the central composite design approach. Results: Optimized transferosome (Batch F8) showed 87.75±3.74 nm (nanometer) particle size and 91.18±2.71% entrapment efficiency. Hydrogel was formulated by Central composite design, selecting pH and spreadability as dependent factors, to which was added curcumin transferosomes, Ascorbic acid and Salicylic acid. The data was analyzed using Stat-ease Design-Expert v7.0.0 software. The optimized batch F3 showed a pH of 6.84, spreadability of 12.89 gm. cm/sec and Curcumin release of 87.47%. Drug release from nanobiocomposite hydrogel was evaluated using the in vitro study of the formulation. The various kinetic models were applied to in vitro release data for the prediction of the drug release kinetic mechanism. The release constants were calculated from the slope of appropriate plots, and the regression coefficient (R2) was determined. It was found that the in vitro drug release of the formulation was best explained by Higuchi as the plots show the highest linearity. The regression coefficient (R2) was found to be 0.907, 0.9266 and 0.9536 for Ascorbic acid, Salicylic acid and Curcumin, respectively. Conclusion: The nanobiocomposite topical formulation was thus prepared, tested and for skin irritancy study. There is no noticeable signs of erythema, edema, or inflammation were observed on the skin. These results indicate that the developed transdermal formulation does not cause skin irritation and can be considered non-irritating.

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Section: Drug Entrapment Efficiency and Its Calculationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Development and Evaluation of Nanobiocomposite Topical Formulation

JADAV,

PATEL,

LATA JHA

2024

Int J App Pharm

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“…Vesicle magnitude should be measured in enhanced transferosomes gel formulations that are submitted to accelerated stability tests under accelerated storage conditions. Diffusion behaviours at predetermined time points, zeta potential [34][35][36][37][38].…”

Section: Stability Studiesmentioning

confidence: 99%

Review on Transferosomes and Transferosomal Gels

Kumar

2021

JPRI

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Transdermal drug delivery systems (TDDS), which are self-administrable and non-invasive, can improve bioavailability and patient compliance by bypassing first-pass metabolism. Vesicular-based TDDS have attracted a lot of attention in recent years because they're designed for controlled, efficient, and targeted drug delivery. One of these delivery technologies, transferosomal-based formulations, has grown in popularity due to its ability to achieve all of the desired criteria and quality qualities. Transferosomes combine the characteristics of liposomes and niosomes because they contain both liposomes (phospholipids and cholesterols) and niosomes as components (nonionic surfactants; edge activators). as a result, they are referred to as the first generation of elastic liposomes. However transdermal drug delivery is difficult due to the presence of the skin's protective barrier, transferosomal drug delivery overcomes all obstacles due to its unique characteristics, such as its ultradeformable vesicular nature. The benefits, limitations, modes of penetration, formulations, production and assessment methodologies, and pharmaceutical uses of transferosomal drug delivery systems are discussed in this paper. Conclusion: Transferosomes have several importance over other vesicular systems, including greater deformability, greater penetration power across skin, the ability to deliver systemic drugs, and higher stability.

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Recent Advances in Combating Acne with Novel Drug Delivery Systems: A Review

D'Sa,

Mahadik,

Patel

et al. 2024

DDL

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Acne vulgaris is an inflammatory disorder of the skin that occurs when hair follicles get clogged with sebum and dead skin cells resulting in pustules, papules, or nodules. This condi-tion affects a large number of people throughout the world. Over time, various conventional ther-apies like topical, systemic and hormonal treatments have been prescribed by doctors to patients for managing acne. Amongst these, topical therapy is the first-line therapy dominated by retinoid and antibiotic drugs. However, conventional topical treatments have many drawbacks concerning physicochemical instability, poor ability to penetrate the skin, and wide-ranging side effects. Novel drug delivery systems are the formulations that were first devised to overcome the issues faced by traditional methods. Researchers have developed novel therapies for topical use, such as niosomes, transfersomes, solid lipid nanoparticles, microsponges, microemulsion, microspheres, nanocochleates, and liposomes, which can be used to target acne. These nanoparticulate systems aim to overcome the disadvantages of conventional treatment and provide higher safety and effi-cacy, along with an increase in the stability of the formulation. Many comparative studies have been conducted between the novel and conventional methods, which give us a better understand-ing of the safety and efficacy of drugs present in the formulation and prove that novel drug deliv-ery systems are more favorable than their conventional counterparts. This review article provides a brief insight into the conventional methods, discusses in depth the earlier mentioned novel ther-apies that can be used successfully in treating acne, and provides patent information on the drug delivery systems.

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Formulation development and evaluation of Transferosomal drug delivery for effective treatment of acne

Cited by 4 publications

References 7 publications

Development and Evaluation of Nanobiocomposite Topical Formulation

Development and Evaluation of Nanobiocomposite Topical Formulation

Review on Transferosomes and Transferosomal Gels

Recent Advances in Combating Acne with Novel Drug Delivery Systems: A Review

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