Formulation Development and Evaluation of Carvedilol Phosphate Gastro Retentive Floating Tablets

Gunda, Raghavendra Kumar; Kumar, J. N. Suresh; Satyanarayana, V; Ramanjaneyulu, K V; Prasad, B Satya

doi:10.7897/2230-8407.0718

Cited by 6 publications

(7 citation statements)

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“…Where, Mt Quantity of drug release at specific time t, M∞ quantity of drug removes at the infinite time; KKP drug release rate constant related to physical and mechanical properties of the tablet, and n is the release exponent indicative of the mechanism of drug release [16][17][18]. Asthma is a chronic disease, once-daily dosing will increase patient's compliance [19,6].…”

Section: Mechanism Of Drug Releasementioning

confidence: 99%

Formulation Development and Evaluation of Doxofylline Sustained-Release Tablets by Using Chitosan and Guar Gum

Avhad

Gupta

2021

JPRI

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The sustained-release dosage form is a well-characterized and reproducible dosage form that is designed to control drug release profile at a certain rate to reach desired drug concentration in blood plasma or at the target site. There is immense demand in the market for new sustained-release formulations used for new drug molecules which release the drug at a sustained rate. Doxofylline is one of the widely useful drugs in the market and needs to be given in a single dose for a long duration of time. For the same, we have prepared a sustained released Doxofylline tablet. Aim: This research was done to design, formulate and evaluate Doxofylline sustained-release tablets by using different concentrations of Chitosan and Guar Gum. Methods: The factorial design was used to prepare Doxofylline sustained-release tablet. Doxofylline sustained-release tablets were prepared to employ different concentrations of Chitosan, Guar Gum, Lactose, and Magnesium Stearate in different combinations by wet granulation technique. Total 9 formulations were designed, formulated, and evaluated for the hardness, thickness, friability, % drug content, and in-vitro drug release. Results: A study of the release of drug by in-vitro found that F8 is to be the best efficient formulation which consists of both Chitosan and Guar Gum helped in delayed the release of drug up to 24 hours and performs excellent release of drug in starting hours of drug release in the body. The drug released from the F8 formulation indicates the kinetic model of First Order, by anomalous diffusion. The formulation F8 shows optimum thickness, hardness and at 40ºC±2 99.35% drug release after 24 hours shows optimum formulation. Conclusion: This study concludes that better drug release was observed by using natural polymers. Doxofylline with natural polymer shows good release and better dissolution rate as compared with a single synthetic polymer. Synthetic drug with natural polymer shows more future scope and this work will help the researcher in the future.

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Section: Mechanism Of Drug Releasementioning

confidence: 99%

Formulation Development and Evaluation of Doxofylline Sustained-Release Tablets by Using Chitosan and Guar Gum

Avhad

Gupta

2021

JPRI

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“…Oral SR dosage form by direct compression is a simple approach of drug delivery systems that proved to be rational in the pharmaceutical arena for its ease, compliance, faster production, avoid hydrolytic or oxidative reactions occurred during processing of dosage forms. [11] The selection of the drug candidates for SR system needs consideration of several biopharmaceutical, pharmacokinetic, and pharmacodynamic properties of drug molecule. [12] In the present study, a SR dosage form of rosuvastatin has been developed which makes less frequent administering of drug.…”

Section: Original Articlementioning

confidence: 99%

“…The technique requires less experimentation and time, thus proving to be far more effective and cost-effective than the conventional methods of formulating SR dosage forms. [20] Hence, an attempt is made in this research work to formulate SR tablets of rosuvastatin using HPMCK4M and SCMC. Instead of normal and trial method, a standard statistical tool design of experiments is employed to study the effect of formulation variables on the release properties.…”

Section: Original Articlementioning

confidence: 99%

Untitled

Rao¹

2018

AJP

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Aim and Objective: The main objective of the present research investigation is to formulate the sustained release (SR) formulation of rosuvastatin. Rosuvastatin, an antihyperlipidemic agent, belongs to Biopharmaceutical Classification System class-II agent. Materials and Methods: The SR tablets of rosuvastatin were prepared by employing different concentrations of hydroxy methyl propyl cellulose (HPMCK4M) and sodium carboxymethyl cellulose (SCMC) in different combinations by direct compression using 3 2 factorial designs. The concentration of polymers, HPMCK4M, and SCMC required to achieve the desired drug release was selected as independent variables, X 1 and X 2 , respectively, whereas time required for 10% of drug dissolution (t 10%), 50% (t 50%), 75% (t 75%), and 90% (t 90%) was selected as dependent variables. Results and Discussion: A total of nine formulations were designed and are evaluated for hardness, friability, thickness, % drug content, and in vitro drug release. From the results, it was concluded that all the formulations were found to be within the pharmacopeial limits and the in vitro dissolution profiles of all formulations were fitted into different kinetic models; the statistical parameters such as intercept, slope, and regression coefficient were calculated. Polynomial equations were developed for dependent variables. The validity of developed polynomial equations was verified by designing 2 check point formulations (C 1 and C 2). According to SUPAC guidelines, the formulation (F 4) containing 30 mg of HPMCK4M and 40 mg of SCMC is the most similar formulation (similarity factor f 2 = 89.561, dissimilarity factor f 1 = 1.543, and no significant difference, t = 0.0056) to marketed product (CRESTOR). Conclusion: The selected formulation (F 4) follows zero-order and Higuchi kinetics, and the mechanism of drug release was found to be non-Fickian Diffusion (n = 0.963).

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“…Formulation Chart of Simvastatin tablets shown in Table 1. 5,7,8,9,18 Bulk density Blend was weighed and transferred to a measuring cylinder. Then bulk volume was noted.…”

Section: Preparation Of Tabletsmentioning

confidence: 99%

Studies on Compression and Drug Release Characteristics of Xanthium Gum Pellets of Different Compositions

Hause¹,

Mitkare²,

Reddy³

2016

Int. Res. J. Pharm.

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The filler used in preparation of pellets affects physical properties, compression and drug release rates. The present investigation was aimed to develop a sustained drug delivery system for a short half life drug, Simvastatin with a view to prolong the release with a sustained release mechanism. Simvastatin is an antilipidaemic agent. Characterization of drug was done by performing the determination of solubility, melting point and FTIR spectroscopy. The prepared batches of pellets were evaluated for micromeritic study such as particle size determination, true density, bulk density, degree of compression, specific surface area and angle of repose. All the batches of pellets were compressed into tablets and evaluated for general appearance, weight variation, hardness, content uniformity, and dissolution study. From the results of all these studies, batch F6 was found to show the best results containing Xanthan gum (16%) and Lactose monohydrates (8%) and selected as an optimized batch. The optimized batch was subjected for further studies such as Scanning Electron Microscopy (SEM) to demonstrate pellets morphology and FTIR to determine the drugpolymer interaction. Optimized formulation was subjected to accelerated stability study for a period of 30 days at 40 ± 2 0 C and 75 ± 5 % RH. Formulation was subjected for thickness, hardness, drug content and in-vitro drug release studies at interval of 15 and 30 days.

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Formulation Development and Evaluation of Carvedilol Phosphate Gastro Retentive Floating Tablets

Cited by 6 publications

References 0 publications

Formulation Development and Evaluation of Doxofylline Sustained-Release Tablets by Using Chitosan and Guar Gum

Formulation Development and Evaluation of Doxofylline Sustained-Release Tablets by Using Chitosan and Guar Gum

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Studies on Compression and Drug Release Characteristics of Xanthium Gum Pellets of Different Compositions

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