2023
DOI: 10.1007/s10792-022-02618-6
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Formulation development and evaluation of therapeutic contact lens loaded with ganciclovir

Abstract: Soft contact lenses have been demonstrated as a promising tool for ocular drug delivery. In the present investigation ganciclovir (GAN) loaded microparticles dispersed in hydrogel-based contact lenses were fabricated to achieve prolonged release and improved permeation of GAN across corneal epithelium. MethodsGAN-Hydroxy Propyl Methyl Cellulose (HPMC) microparticles were prepared by solvent evaporation method and evaluated for entrapment e ciency, drug content and drug release. The Polyhydroxyethylmethacrylate… Show more

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(2 citation statements)
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“…10 tablets were dissolved in 0.1N Hcl solution at room temperature and absorbance was taken at 254 nm by using a UV spectrophotometer to determine the amount of valganciclovir hydrochloride [12].…”
Section: Drug Contentmentioning
confidence: 99%
See 1 more Smart Citation
“…10 tablets were dissolved in 0.1N Hcl solution at room temperature and absorbance was taken at 254 nm by using a UV spectrophotometer to determine the amount of valganciclovir hydrochloride [12].…”
Section: Drug Contentmentioning
confidence: 99%
“…To determine the floating lag time, tablets were put on 100 mL of 0.1 N HCL in a beaker, and the time is required for a tablet to rise on the surface was measured. Then, the duration of each formulation that remained on the surface was determined as total floating [13].…”
Section: Determination Of Floating Lag Time and Total Floating Timementioning
confidence: 99%