Formulation Development and Evaluation of Bilayer Tablets Containing Paracetamol SR and Tizanidine

Sarangi, Manoj Kumar; Chowdary, Kpr; Sundriyal, Ankush

doi:10.21065/19204159.6.4.316

Journal of Applied Pharmacy

2014

DOI: 10.21065/19204159.6.4.316

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Formulation Development and Evaluation of Bilayer Tablets Containing Paracetamol SR and Tizanidine

Manoj Kumar Sarangi¹,

Kpr Chowdary²,

Ankush Sundriyal³

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“…Bi-layer tablet is suitable for sequential release of two drugs in combination in which one layer is for immediate release and second layer is sustained release. Hence, the use of bi-layer tablets is a very different aspect for anti-inflammatory, analgesic, diabetic, and anti-hypertensive drugs where combination therapy is often used [12,13].…”

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confidence: 99%

Bilayer Tablet Tendered Immediate Release of Paracetamol and Sustained Release of Ibuprofen for Quick Onset of Action Against Pain and Fever

Chauhan

Kaushik

2019

Asian J Pharm Clin Res

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Objective: The objective of this research was to formulate bi-layer tablet which contains immediate-release layer of Paracetamol for quick onset of action and sustained release of Ibuprofen for prolonging long period. Materials and Methods: The following chemicals were used: Paracetamol (Combiotic Global Pvt. Ltd., India), Ibuprofen (Combiotic Global Pvt. Ltd., India), microcrystalline cellulose (MCC) (Avicel), and Polyvinylpyrrolidone (PVP) K-30 (Loba Chem). Wet granulation method was adapted to formulate the bilayer tablets. The immediate-release layer of Paracetamol was prepared using sodium starch glycolate as superdisintegrants, MCC as diluent, starch as binder. The sustained release layer of Ibuprofen was prepared using high-performance liquid chromatography E50LV and ethyl cellulose as binder along with other excipients such as MCC, PVP, and magnesium stearate by wet granulation technique. Result and Discussion: The release rate of Paracetamol from Formulations 1 was more than 80% at 40 min. In case of Ibuprofen, sustained-release polymers such as HPMC E50 LV were used to increase the release time. Conclusion: The bilayer tablets were prepared and show good release rate.

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mentioning

confidence: 99%

Bilayer Tablet Tendered Immediate Release of Paracetamol and Sustained Release of Ibuprofen for Quick Onset of Action Against Pain and Fever

Chauhan

Kaushik

2019

Asian J Pharm Clin Res

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Formulation Development and Evaluation of Bilayer Tablets Containing Paracetamol SR and Tizanidine

Cited by 1 publication

References 4 publications

Bilayer Tablet Tendered Immediate Release of Paracetamol and Sustained Release of Ibuprofen for Quick Onset of Action Against Pain and Fever

Bilayer Tablet Tendered Immediate Release of Paracetamol and Sustained Release of Ibuprofen for Quick Onset of Action Against Pain and Fever

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