2013
DOI: 10.5731/pdajpst.2013.00916
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Formulation, Development, and Evaluation of Floating Pulsatile Drug Delivery System of Atenolol

Abstract: The objective of the present work was to develop a floating-pulsatile oral drug delivery system of atenolol with addition of hydroxylpropyl methylcellulose (HPMC) K100 M, HPMC K4 M, and HPMC E15 LV in different ratios with citric acid and sodium bicarbonate as gas-forming agents. The system consist of three different parts: a core tablet, containing the active ingredient; a bottom layer that erodes; and a top cover floating layer. Atenolol, a β-blocker, is prescribed widely in diverse cardiovascular diseases, … Show more

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Cited by 12 publications
(5 citation statements)
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“…This equation describes the relative significance of Fickian (n ≤ 0.5) and Case II (n ≤ 1.0) transport in anomalous diffusion. Kinetic studies were performed by adjusting the release profiles to Higuchi, first-order and zero-order kinetics equations 55 . pharmacological study.…”
Section: Formulation Of Medicated Mn Arraysmentioning
confidence: 99%
“…This equation describes the relative significance of Fickian (n ≤ 0.5) and Case II (n ≤ 1.0) transport in anomalous diffusion. Kinetic studies were performed by adjusting the release profiles to Higuchi, first-order and zero-order kinetics equations 55 . pharmacological study.…”
Section: Formulation Of Medicated Mn Arraysmentioning
confidence: 99%
“…Press coating was used to create a unique colon-focused tablet formulation, which is a quickly dissolving tablet of atenolol with guar gum and Eudragit L-100 as a barrier layer. Different polymer ratios were used to provide an appropriate lag time for the treatment of angina pectoris [34]. Patil created a chrono-regulated pulsatile drug delivery system for captopril, which is used to treat cardiovascular disease (hypertension).…”
Section: The Cardiovascular Systemmentioning
confidence: 99%
“…The value of n for formulations OF-1 to OF-9 was in the range of 0.48-0.60 which indicates the drug transport mechanism to be anomalous transport (n = 0.45-0.89). [28] Characterization study by FTIR spectroscopy FTIR spectrophotometry was carried out for identification and affinity of formulation composition. The FT-IR spectra of ketorolac tromethamine show O-H stretching at 2916 cm -1 , N-H stretching at 3345 cm -1 , aromatic C-H stretching at 2848 cm -1 , C=O stretching at 1651 cm -1 , while C=C and C-N stretching show at 1579 and 1244 cm -1 , respectively.…”
Section: Simentioning
confidence: 99%