Formulation Development and Evaluation of a Gastroretentive in situ oral gel of Cefuroxime Axetil

Shastri, Divyesh H; Dodiya, Hitesh; Shelat, Pragna K.; Bhanupriy, Alkesh Kishanlal

doi:10.5530/jyp.2016.4.6

Cited by 16 publications

(7 citation statements)

References 16 publications

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“…The release of drug from these formulae was characterized by an initial phase of high release (burst effect) followed by the second phase of moderate release. This biphasic pattern of release is a characteristic feature of matrix diffusion kinetics [26].…”

Section: In Vitro Drug Release Studymentioning

confidence: 92%

Enhance Solubility and Prolong Release of Prochlorperazine Maleate Using Floating Nanoemulsion in Situ Gel

Аlmajidi¹,

Albaderi²,

Fadhel³

2019

Asian J Pharm Clin Res

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Objective: The objective of this study was to prepare floating gastric in situ gel of prochlorperazine maleate (PM) using nanoemulsion technology to improve drug solubility, bioavailability, reduce dosing frequency, and patient compliance.Methods: Eight nanoemulsion formulas (F1–F8) of PM were prepared by ultrasonication method using oil, surfactants: cosurfactants (Smix) with different types, concentrations, and ratios, and deionized distilled water. The nanoemulsion formulas were characterized to select the optimum recipe from which six floating in situ gel formulas (floating nanoemulsion in situ [FNI] 1-FNI 6) were prepared using sodium alginate as gelling agent, hydroxypropyl methylcellulose (HPMCK) 4M as rate retarding polymer, calcium chloride as cross-linking agent, calcium carbonate as floating agent, and sodium citrate as buffering and neutralizing gastric acid. All FNI formulas were subjected for the evaluation to assess the formulations suitability concerning the dosage form and intended therapeutic purpose.Results: Formulation variables such as the concentration of sodium alginate, HPMCK 4M, calcium carbonate, and calcium chloride affected the gelling properties, formulation viscosity, floating behavior, and in vitro drug release. Formulation FNI 6 showed acceptable floating lag time (55±2.3 s) and >12 h floating duration time, and observe prolong release of the drug in in-situ gelling preparation.Conclusion: The prepared FNI formulas of PM could float in the gastric conditions and released the drug in a sustained manner. The present formulation was enhanced drug solubility with good retention properties and better patient compliance.

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Section: In Vitro Drug Release Studymentioning

confidence: 92%

Enhance Solubility and Prolong Release of Prochlorperazine Maleate Using Floating Nanoemulsion in Situ Gel

Аlmajidi¹,

Albaderi²,

Fadhel³

2019

Asian J Pharm Clin Res

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“…The thixotropic analysis showed some non-Newtonian pseudoplastic timedependent change in viscosity. It was concluded that fluids attained an even viscosity with respect to shear rate [34].…”

Section: Rheological Properties Of the Formulationmentioning

confidence: 99%

Design and development of sodium alginate/ carboxymethyl cellulose in situ gelling system for gastroretentive delivery of lisinopril

PATIL¹,

PATIL²,

BHARADE³

et al. 2023

jrp

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Lisinopril is a potent ACE (angiotensin-converting enzyme) inhibitor used to treat hypertension and congestive heart failure. It exhibits 25% of low bioavailability. Hence, in the current study, the major objective was to increase the gastric transient time of lisinopril and develop in situ gel formulation for better absorption and modulating release behavior of lisinopril. Different formulations of lisinopril were prepared by using gelling polymers such as Carboxymethyl cellulose (CMC), pectin, and calcium carbonate. Sodium citrate was used to prevent gelation outside the gastric environment. The formulation was studied using Fourier Transform Infrared Spectroscopy (FTIR) and Differential Scanning Calorimetry (DSC) to interpret the interaction between drugsand polymers. For optimization of in situ gelling system 3 2 full factorial design was employed to study the effect of independent variables, the concentration of CMC (X1) and concentration of sodium alginate (X2), on the dependent variables viscosity, and % drug content. Formulation (F5) containing 1.25% of sodium alginate, and 0.75% of CMC showed good gelling ability. The composition F5 was optimized on the basis of viscosity (5.03 Pa.s), drug content (94.06±1.0%), and cumulative drug release (95±0.73%) at 12 h. Floating in situ gelling system improved bioavailability and gastric transit time of lisinopril. A stability study indicated the absence of any noticeable change in the formulation. Thus, in situ gel formulation is a promising approach for gastro-retentive sustained delivery of lisinopril. These results ensure that the developed system is an alternative to conventional drug delivery systems and can enhance patient compliance.

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“…Mucoadhesive polymers such as chitosan (CTS), pectin, Carbopol ® , polyacrylic acid (PAA), and sodium carboxymethylcellulose (NaCMC) were reported as materials of interest in the preparation of mucoadhesive GRDDSs, as well as gums such as guar gum, gellan gum, and xanthan gum, and thiolated polymers, among others (Table 3). Polycarbophil ® [101] NaCMC [104] Anionic polysaccharides and gums NaAlg [98,105] Pectin [106,107] Gellan gum [90] Xanthan gum [105,108] Other polysaccharides and gums…”

Section: Mucoadhesive Formulationsmentioning

confidence: 99%

Scope and Limitations of Current Antibiotic Therapies against Helicobacter pylori: Reviewing Amoxicillin Gastroretentive Formulations

Grosso

de-Paz

2022

Pharmaceutics

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Even though general improvement of quality of life has happened around the globe, statistics show that gastric cancer is still a very serious medical concern in some regions of the world. A big portion of malignant neoplasms that develop inside the stomach are linked to an infection of Helicobacter pylori; in fact, this pathogen has already been categorized as a group 1 carcinogen by the World Health Organization (WHO). Still, the efficacy of current anti-H. pylori therapeutic approaches is insufficient and follows a worrying decreasing trend, mainly due to an exponential increase in resistance to key antibiotics. This work analyzes the clinical and biological characteristics of this pathogen, especially its link to gastric cancer, and provides a comprehensive review of current formulation trends for H. pylori eradication. Research effort has focused both on the discovery of new combinations of chemicals that function as optimized antibiotic regimens, and on the preparation of gastroretentive drug delivery systems (GRDDSs) to improve overall pharmacokinetics. Regarding the last topic, this review aims to summarize the latest trend in amoxicillin-loaded GRDDS, since this is the antibiotic that has shown the least bacterial resistance worldwide. It is expected that the current work could provide some insight into the importance of innovative options to combat this microorganism. Therefore, this review can inspire new research strategies in the development of efficient formulations for the treatment of this infection and the consequent prevention of gastric cancer.

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Formulation Development and Evaluation of a Gastroretentive in situ oral gel of Cefuroxime Axetil

Cited by 16 publications

References 16 publications

Enhance Solubility and Prolong Release of Prochlorperazine Maleate Using Floating Nanoemulsion in Situ Gel

Enhance Solubility and Prolong Release of Prochlorperazine Maleate Using Floating Nanoemulsion in Situ Gel

Design and development of sodium alginate/ carboxymethyl cellulose in situ gelling system for gastroretentive delivery of lisinopril

Scope and Limitations of Current Antibiotic Therapies against Helicobacter pylori: Reviewing Amoxicillin Gastroretentive Formulations

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