Formulation Development and in Vitro Evaluation of in Situ Lisinopril Gel for Nasal Administration

Abstract

Nasal route is the most suitable route for those preparations which cannot be administered orally due to the first pass metabolism to avoid this nasal route is very convenient route of administration of drug. The aim of present work was to prepare gel of lisinopril drug for intranasal route of administration, along with various excipients like gallan gum, polyethylene glycol-400(PEG-400), Mannitol, tween-80, benzalkonium chloride and distilled water. Four batches of formulations were designed, prepared and evaluated for various evaluation parameters like drug content, viscosity, mucoadhesive strength and spreadibility. Stability studies was performed and it was found that there is no significant changes in the formulation when exposed to stressed conditions like temperature and humidity for several period of time. On histopathological evaluation of optimized formulation neither cell necrosis nor removal of the epithelium from the nasal mucosa was observed after application of formulation. By seeing the results of all four formulations it was found that the batch R3 is optimized formulation.KEYWORD: PEG400, IR, DSC.