Formulation Development and In vitro Characterisation of Stavudine Extended Release Matrix Tablets

Abstract

The aim of the present study was to develop Stavudine extended release tablets to maintain constant therapeutic levels of the drug for over 12 hrs. Xanthan gum, Sodium CMC and HPMC 15cps were used as polymers. All the formulations were passed various physicochemical evaluation parameters such as Bulk Density, Tapped Density, Carr’s Index, Hausners Ratio, Angle of Repose, Weight Variation, Hardness, Thickness, Friability and Drug Content. From the dissolution studies it was evident that the formulation F6 showed better and desired drug release pattern i.e., 99.12% in 12 hours. It contains the Sodium CMC as polymer. It followed Kars Mayer peppas release kinetics mechanism.