Formulation Development, Characterization and  In-vitro Evaluation of Tamoxifen Loaded Liposomes

Hasan, Md. Mazed; Hamiduzzaman, Md.; Jahan, Ishrat; Hasan, A. H. M. Nazmul; Asaduzzaman, Md.

doi:10.9734/jpri/2020/v32i630449

Cited by 3 publications

(2 citation statements)

References 28 publications

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“…The prepared liposomes, characterized by using optical microscopy, evidenced an increased encapsulation efficiency (from about 60% to 86%) as a function of the increasing amount of phospholipids and cholesterol, while in vitro (by means of the dialysis membrane) and ex vivo (by means of the chicken intestinal sac,) diffusion studies evidenced an efficient and controlled release process. The study evidenced a similar performance of the liposome system prepared by the two different methods [86]. A variation of this method is given by the inkjet method, based on the employment of commercial inkjet printers (and cartridges), which are used to inject the lipid solution into the water phase [87].…”

Section: Ether Injection Methodsmentioning

confidence: 74%

“…Recently, different liposomes loaded with tamoxifen (a hormone used to treat breast cancer) were prepared by modified ether injection (MEIM) and thin-film hydration methods (TFHM) [ 86 ]. The prepared liposomes, characterized by using optical microscopy, evidenced an increased encapsulation efficiency (from about 60% to 86%) as a function of the increasing amount of phospholipids and cholesterol, while in vitro (by means of the dialysis membrane) and ex vivo (by means of the chicken intestinal sac,) diffusion studies evidenced an efficient and controlled release process.…”

Section: Conventional Methods For the Preparation Of Liposomesmentioning

confidence: 99%

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Methods of Liposomes Preparation: Formation and Control Factors of Versatile Nanocarriers for Biomedical and Nanomedicine Application

2022

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Liposomes are nano-sized spherical vesicles composed of an aqueous core surrounded by one (or more) phospholipid bilayer shells. Owing to their high biocompatibility, chemical composition variability, and ease of preparation, as well as their large variety of structural properties, liposomes have been employed in a large variety of nanomedicine and biomedical applications, including nanocarriers for drug delivery, in nutraceutical fields, for immunoassays, clinical diagnostics, tissue engineering, and theranostics formulations. Particularly important is the role of liposomes in drug-delivery applications, as they improve the performance of the encapsulated drugs, reducing side effects and toxicity by enhancing its in vitro- and in vivo-controlled delivery and activity. These applications stimulated a great effort for the scale-up of the formation processes in view of suitable industrial development. Despite the improvements of conventional approaches and the development of novel routes of liposome preparation, their intrinsic sensitivity to mechanical and chemical actions is responsible for some critical issues connected with a limited colloidal stability and reduced entrapment efficiency of cargo molecules. This article analyzes the main features of the formation and fabrication techniques of liposome nanocarriers, with a special focus on the structure, parameters, and the critical factors that influence the development of a suitable and stable formulation. Recent developments and new methods for liposome preparation are also discussed, with the objective of updating the reader and providing future directions for research and development.

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Section: Ether Injection Methodsmentioning

confidence: 74%

Section: Conventional Methods For the Preparation Of Liposomesmentioning

confidence: 99%

Methods of Liposomes Preparation: Formation and Control Factors of Versatile Nanocarriers for Biomedical and Nanomedicine Application

2022

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Conventional methods for preparing liposomes of various types (MLVs, LUVs, SUVs)

Manca,

Aroffu,

Fulgheri

et al. 2024

Liposomes in Drug Delivery

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Recent Advances in Nanocarrier-based Approaches to Atopic Dermatitis and Emerging Trends in Drug Development and Design

Amisha,

Singh,

Kurmi

et al. 2024

CDD

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Atopic dermatitis (AD), commonly known as Eczema, is a non-communicable skin condition that tends to become chronic. The deteriorating immunological abnormalities are marked by mild to severe erythema, severe itching, and recurrent eczematous lesions. Different pharmacological approaches are used to treat AD. The problem with commercial topical preparations lies in the limitation of skin atrophy, systemic side effects, and burning sensation that decreases patient compliance. The carrier-based system promises to eliminate these shortcomings; thus, a novel approach to treating AD is required. Liposomes, microemulsions, solid lipid nanoparticles (SLNs), nanoemulsions, etc., have been developed recently to address this ailment. Despite extensive research in the development method and various techniques, it has been challenging to demonstrate the commercial feasibility of these carrier-based systems, which illustrates a gap among the different research areas. Further, different soft wares and other tools have proliferated among biochemists as part of a cooperative approach to drug discovery. It is crucial in designing, developing, and analyzing processes in the pharmaceutical industry and is widely used to reduce costs, accelerate the development of biologically innovative active ingredients, and shorten the development time. This review sheds light on the compilation of extensive efforts to combat this disease, the product development processes, commercial products along with patents in this regard, numerous options for each step of computer-aided drug design, including in silico pharmacokinetics, pharmacodynamics, and toxicity screening or predictions that are important in finding the drug-like compounds.

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Formulation Development, Characterization and In-vitro Evaluation of Tamoxifen Loaded Liposomes

Cited by 3 publications

References 28 publications

Methods of Liposomes Preparation: Formation and Control Factors of Versatile Nanocarriers for Biomedical and Nanomedicine Application

Methods of Liposomes Preparation: Formation and Control Factors of Versatile Nanocarriers for Biomedical and Nanomedicine Application

Conventional methods for preparing liposomes of various types (MLVs, LUVs, SUVs)

Recent Advances in Nanocarrier-based Approaches to Atopic Dermatitis and Emerging Trends in Drug Development and Design

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