Formulation of a drug delivery system based on a mixture of monoglycerides and triglycerides for use in the treatment of periodontal disease

Norling, T.; Lading, Pia; Engström, Sven; Larsson, Kåre; Krog, N.; Nissen, Søren Søe

doi:10.1111/j.1600-051x.1992.tb02529.x

Cited by 150 publications

(89 citation statements)

References 19 publications

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“…In this study, a mixture of glycerile monooleate (GMO) and sesame oil was selected as an anhydrous and nontoxic delivery system for doxycycline hyclate, based on its use in a previous study in which GMO and sesame oil mixture was used as a delivery system for metronidasole (33). Sesame oil, a triglyceride with a low melting point, was used in order to modulate the consistency of the product.…”

Section: Preparation Of Doxycycline Hyclate Gelmentioning

confidence: 99%

“…It is a controlled release vehicle for some drugs (33). To prepare doxycycline hyclate gel in GMO and sesame oil mixture, 5% sesame oil was added to 95% of the melted GMO at 60-70°C with continuous stirring.…”

Section: Preparation Of Doxycycline Hyclate Gelmentioning

confidence: 99%

“…Oral Sci. 46, [25][26][27][28][29][30][31][32][33][34][35] 2004) Key Words: tetracycline; systemic doxycycline; local doxycycline; periodontal treatment; local drug delivery; chronic periodontitis. …”

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confidence: 99%

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A comparative evaluation of the clinical effects of systemic and local doxycycline in the treatment of chronic periodontitis

et al. 2004

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In this study, the clinical efficacies of systemic doxycycline (SD) and local doxycycline (LD) in the treatment of chronic periodontitis were compared. Forty-five patients were studied in 3 main groups with 5 treatments: SD alone, SD+scaling-root planing (SD+SRP), LD alone, LD+SRP and SRP alone. Antibiotic-treated patients were given doxycycline treatment alone in 1 quadrant of their upper jaws, and doxycycline+SRP was given in the contralateral quadrant. The areas included at least 4 teeth with ≥ 5 mm pockets. Probing depth (PD), clinical attachment level, gingival index, sulcular bleeding index and plaque index values were recorded at baseline and the 7 th week. The results were statistically analyzed. All of the clinical parameters were significantly reduced by all treatments (P ≤ 0.05). The SD and LD treatments alone provided significant clinical healings. The significant differences among the groups were only in PD at the 7th week. The LD treatment provided significantly higher PD reduction than the SD treatment (P ≤ 0.05). No significant difference was found between the SD+SRP and the LD+SRP treatments. There was no significant difference between SD+SRP and SRP alone treatment (P > 0.05). The SD group showed lower PD reduction than SRP group (P ≤ 0.05), while no significant difference was found between LD and SRP treatments. The LD alone treatment seemed more effective than SD alone treatment on PD reduction, but no significant difference was found between them when combined with the SRP. LD may be more preferable than SD as an adjunct to mechanical treatment since LD seems more effective than SD on PD reduction and does not have the side effects of SD. (J. Oral Sci. 46, [25][26][27][28][29][30][31][32][33][34][35] 2004) Key Words: tetracycline; systemic doxycycline; local doxycycline; periodontal treatment; local drug delivery; chronic periodontitis. IntroductionCurrently, periodontal disease is accepted as an infection of the periodontium since the primary etiologic factor is bacteria, which triggers the host immune response and the consequent tissue destruction. Because of its infectious nature, in a biological view, the main target for periodontal treatment must be the suppression of the effective bacteria (1,2). In light of this conceptual development, it recently has been considered that mechanical treatment alone is insufficient in the periodontal treatment strategy. Antimicrobial therapy, especially antibiotic treatment, is of special importance as an adjunct to mechanical periodontal treatment (1,3,4).To date, the most widely used antibiotics in the treatment of periodontal disease have been tetracyclines since they show the highest concentrations in gingival crevicular fluid (GCF) and are highly effective on Actinobacillus Actinomycetemcomitans (Aa) (5,6). Recently, some nonJournal of Oral Science, Vol. 46, No. 1, 25-35, 2004 7,8). In one of the studies, patients with moderate chronic periodontitis were administered doxycycline for 2 weeks prior to a full-thickness flap procedur...

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Section: Preparation Of Doxycycline Hyclate Gelmentioning

confidence: 99%

Section: Preparation Of Doxycycline Hyclate Gelmentioning

confidence: 99%

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A comparative evaluation of the clinical effects of systemic and local doxycycline in the treatment of chronic periodontitis

et al. 2004

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“…They can incorporate small-molecule drugs and large proteins, 11,12 and have the ability to enhance permeability. 13 Currently commercialized preparations of paeonol include a cyclodextrin injection, oral solution, and ointment.…”

Section: Introductionmentioning

confidence: 99%

Transdermal delivery of paeonol using cubic gel and microemulsion gel

Luo¹,

Shen²,

Chen³

2011

IJN

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Background The aim of this study was to develop new systems for transdermal delivery of paeonol, in particular microemulsion gel and cubic gel formulations. Methods Various microemulsion vehicles were prepared using isopropyl myristate as an oil phase, polyoxyethylated castor oil (Cremophor ® EL) as a surfactant, and polyethylene glycol 400 as a cosurfactant. In the optimum microemulsion gel formulation, carbomer 940 was selected as the gel matrix, and consisted of 1% paeonol, 4% isopropyl myristate, 28% Cremophor EL/polyethylene glycol 400 (1:1), and 67% water. The cubic gel was prepared containing 3% paeonol, 30% water, and 67% glyceryl monooleate. Results A skin permeability test using excised rat skins indicated that both the cubic gel and microemulsion gel formulations had higher permeability than did the paeonol solution. An in vivo pharmacokinetic study done in rats showed that the relative bioavailability of the cubic gel and microemulsion gel was enhanced by about 1.51-fold and 1.28-fold, respectively, compared with orally administered paeonol suspension. Conclusion Both the cubic gel and microemulsion gel formulations are promising delivery systems to enhance the skin permeability of paeonol, in particular the cubic gel.

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“…The addition of drugs or additives to liquid crystalline systems can modify the phase structures and system properties, which may influence drug release profiles (20,21,26,34,35). Several authors have reported altered properties in the liquid crystalline phase of monoolein/water systems due to the addition of drugs and solvents (18,20,25,34,(36)(37)(38)(39). The presence of a drug can affect the curvature of the lipid bilayer and change the average area of the lipid head group, which changes monoglyceride molecular packing and promotes a phase transition (18,23).…”

Section: Discussionmentioning

confidence: 99%

Liquid Crystalline Systems for Transdermal Delivery of Celecoxib: In Vitro Drug Release and Skin Permeation Studies

et al. 2014

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Abstract. Liquid crystalline systems of monoolein/water could be a promising approach for the delivery of celecoxib (CXB) to the skin because these systems can sustain drug release, improve drug penetration into the skin layers and minimize side effects. This study evaluated the potential of these systems for the delivery of CXB into the skin based on in vitro drug release and skin permeation studies. The amount of CXB that permeated into and/or was retained in the skin was assayed using an HPLC method. Polarizing light microscopy studies showed that liquid crystalline systems of monoolein/water were formed in the presence of CXB, without any changes in the mesophases. The liquid crystalline systems decreased drug release when compared to control solution. Drug release was independent of the initial water content of the systems and CXB was released from cubic phase systems, irrespective of the initial water content. The systems released the CXB following zero-order release kinetics. In vitro drug permeation studies showed that cubic phase systems allowed drug permeation and retention in the skin layers. Cubic phase systems of monoolein/water may be promising vehicles for the delivery of CXB in/through the skin because it improved CXB skin permeation compared with the control solution.

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Formulation of a drug delivery system based on a mixture of monoglycerides and triglycerides for use in the treatment of periodontal disease

Cited by 150 publications

References 19 publications

A comparative evaluation of the clinical effects of systemic and local doxycycline in the treatment of chronic periodontitis

A comparative evaluation of the clinical effects of systemic and local doxycycline in the treatment of chronic periodontitis

Transdermal delivery of paeonol using cubic gel and microemulsion gel

Liquid Crystalline Systems for Transdermal Delivery of Celecoxib: In Vitro Drug Release and Skin Permeation Studies

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