Formulation of a lyophilized dry emulsion tablet for the delivery of poorly soluble drugs

Enhancing the aqueous solubility and dissolution of olanzapine using freeze-drying

“…The matrix of the freeze-drying RDT consists of two components that work together to ensure the development of a successful formulation. The first component consists of water-soluble polymers, such as gelatin, dextrin, alginate and maltodextrin (Corveleyn et al, 1998;Chandrasekhar et al, 2009). This component maintains the shape and provides mechanical strength to the tablets (binder).…”

“…The second constituent consists of matrix-supporting/disintegration-enhancing agents, such as sucrose and mannitol, which act by cementing the porous framework provided by the water-soluble polymer and accelerate the disintegration of the RDT (Farhan et al, 2010). Although there is wide availability of literature describing the preparation of RDT by freeze-drying, the number of matrix-supporting/disintegration-enhancing agents used has been limited to saccharides and polyols, with the majority of the work dedicated to the inclusion of mannitol (Segar, 1998;Corveleyn et al, 1998;Farhan et al, 2010). This is primarily because the incorporation of these matrix-forming agents requires fulfillment of stringent characteristics, such as reasonable drying time and stability during freeze-drying process, as well as formation of elegant tablets with short disintegration time and adequate mechanical properties.…”

Olive oil and lemon salad dressing microencapsulated by freeze-drying

“…In some studies, the porosity of tablet decreased with increasing maltodextrin D38 concentration. Higher maltodextrin concentrations in the solution to be freeze-dried result in smaller ice crystals and smaller pore sizes (Corveleyn & Remon, 1997;1998). No significant effect of maltodextrin type, value of DE nor residual moisture concentration in the tablet was observed.…”

Preparation of fenofibrate dry emulsion and dry suspension using octenyl succinic anhydride starch as emulsifying agent and solid carrier

“…After drying process, the dispersed lipid phase was encapsulated by solid carrier, which was water soluble such as trehalose, mannitol (Hansen et al, 2004), lactose monohydrate (Yin et al, 2009), hydroxypropyl methylcellulose (Christensen et al, 2001a;Hansen et al, 2005;Yin et al, 2009), dextrin (Jang et al, 2006;Yin et al, 2009), maltodextrin (Corveleyn and Remon, 1998) and water-insoluble carrier such as magnesium alumino metasilicate (Hansen et al, 2004). Conventional unit dosage forms such as tablets (Ahmed and Aboul-Einien, 2007;Christensen et al, 2001b;Corveleyn and Remon, 1998;Hansen et al, 2005Hansen et al, , 2004 and capsules (Takeuchi et al, 1991) of DE have been prepared to earn more advantages in terms of dosing, handling, and patient compliance.…”

“…DEs have been prepared by spray drying (Christensen et al, 2001a;Dollo et al, 2003;Hansen et al, 2004;Jannin et al, 2008), lyophilisation (Corveleyn and Remon, 1998) and rotary evaporation (Zu et al, 2014) in order to remove the aqueous phase of liquid o/w emulsion. After drying process, the dispersed lipid phase was encapsulated by solid carrier, which was water soluble such as trehalose, mannitol (Hansen et al, 2004), lactose monohydrate (Yin et al, 2009), hydroxypropyl methylcellulose (Christensen et al, 2001a;Hansen et al, 2005;Yin et al, 2009), dextrin (Jang et al, 2006;Yin et al, 2009), maltodextrin (Corveleyn and Remon, 1998) and water-insoluble carrier such as magnesium alumino metasilicate (Hansen et al, 2004).…”