Formulation of double microemulsion based on pH-responsive PEG/PVA/zinc oxide as a potential nano-platform for drug delivery: Green synthesis, and physico-chemical characterization

Gholami., Arezoo; Pourmadadi., Mehrab; Abdouss., Hamidreza; Amiri., Zeynab; Abdouss., Majid; Rahdar, Abbas; Behzadmehr., Razieh; Pandey, Sadanand

doi:10.1016/j.molliq.2024.125563

Journal of Molecular Liquids

2024

DOI: 10.1016/j.molliq.2024.125563

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Formulation of double microemulsion based on pH-responsive PEG/PVA/zinc oxide as a potential nano-platform for drug delivery: Green synthesis, and physico-chemical characterization

Arezoo Gholami.,

Mehrab Pourmadadi.,

Hamidreza Abdouss.

et al.

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Cited by 3 publications

References 79 publications

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Influence of protein composition on thermodynamics of biomolecular interactions of iron oxide nanoformulations

Pandey,

Sharma,

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Journal of Molecular Liquids

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Influence of protein composition on thermodynamics of biomolecular interactions of iron oxide nanoformulations

Pandey,

Sharma,

Choudhary

et al. 2025

Journal of Molecular Liquids

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pH-Induced Structural Changes of Crystalline Curcumin Enhance Its Encapsulation in Emulsions

Gong,

Suryamiharja,

Zhou

2024

ACS Food Sci. Technol.

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The simple and green pH-based method shows promise for encapsulating hydrophobic molecules in delivery systems to enhance their bioavailability. However, there is still a limited understanding of the pH-induced structural changes that are involved. In this study, we combine experimental techniques with molecular dynamics simulations to investigate pH-induced structural changes in curcumin crystals. An alkali-acid pretreatment was introduced to encapsulate curcumin, where curcumin is first dissolved in an alkaline solution and then rapidly acidified to form aggregates. Remarkably, these curcumin aggregates can be spontaneously encapsulated into emulsions, even at high concentrations (1 mg/mL). Microscopy images suggested that this pretreatment disrupts the crystalline structure of curcumin. Molecular dynamics simulations further demonstrated that the hydroxyl groups of curcumin form hydrogen bonds with water molecules, while the hydrophobic interactions dominate within pH-treated curcumin aggregates. The structural changes increase the solvent-accessible surface area and promote the rapid solubilization of curcumin into emulsions or milks.

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Metal Oxide Nanoparticles as Efficient Nanocarriers for Targeted Cancer Therapy: Addressing Chemotherapy-Induced Disabilities

Yassin,

Al-Otibi,

Al-Sahli

et al. 2024

Cancers

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Cancer remains a predominant global health concern, necessitating effective treatment options. Conventional cancer therapies, particularly chemotherapy, often face constraints such as low selectivity, insufficient solubility, and multidrug resistance (MDR), which diminish effectiveness and exacerbate negative effects. Metal oxide nanoparticles (MONPs), such as iron oxide, zinc oxide, and copper oxide, offer a promising solution by enhancing targeted drug delivery, reducing systemic toxicity, and mitigating chemotherapy-induced disabilities like neurotoxicity and cardiotoxicity. Nanocarriers conjugated with drugs can improve drug delivery within the body and enhance their circulation in the bloodstream. Recent advancements in MONP synthesis and functionalization have further improved their stability and drug-loading capacity, making them a valuable tool in cancer treatment. MONPs have distinctive physicochemical characteristics, enabling better imaging, drug encapsulation, and targeted medication delivery to cancerous cells. These nanocarriers enhance treatment effectiveness through focused and controlled drug release, reducing off-target effects and addressing drug resistance. This review aims to explore the potential of MONPs as efficient nanocarriers for anticancer drugs, addressing limitations of traditional chemotherapy such as poor specificity, systemic toxicity, and drug resistance. Additionally, the review discusses recent advancements in MONP synthesis and functionalization, which enhance their stability, drug-loading capacity, and compatibility.

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Formulation of double microemulsion based on pH-responsive PEG/PVA/zinc oxide as a potential nano-platform for drug delivery: Green synthesis, and physico-chemical characterization

Cited by 3 publications

References 79 publications

Influence of protein composition on thermodynamics of biomolecular interactions of iron oxide nanoformulations

Influence of protein composition on thermodynamics of biomolecular interactions of iron oxide nanoformulations

pH-Induced Structural Changes of Crystalline Curcumin Enhance Its Encapsulation in Emulsions

Metal Oxide Nanoparticles as Efficient Nanocarriers for Targeted Cancer Therapy: Addressing Chemotherapy-Induced Disabilities

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