Formulation of inclusion complex of Abiraterone acetate with 2-Hydroxypropyl-Beta-Cyclodextrin: physiochemical characterization, molecular docking and bioavailability evaluation

Tamizhmathy, M.; Gupta, Ujala; Shettiwar, Arti; Kumar, Gogikar Shiva; Daravath, Sandeep; Aalhate, Mayur; Mahajan, Srushti; Maji, Indrani; Sriram, Anitha; Modak, Chandrima; Rajalakshmi, A.N.; Dikundwar, Amol G.; Doijad, Nandkumar; Guru, Santosh Kumar; Singh, Pankaj Kumar

doi:10.1016/j.jddst.2023.104321

Cited by 6 publications

(2 citation statements)

References 39 publications

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“…The results indicated that the aqueous solubility and in vitro dissolution rate of DTX/DM‐β‐CD IC were 76.04‐ and 3.55‐fold than that of free DTX powder, respectively [8a] . Tamizhmathy et al prepared abiraterone acetate‐2‐hydroxypropyl‐β‐CD (ABT‐HP‐β‐CD)IC by freeze‐drying method, and the in vivo plasma pharmacokinetic study showed that compared with the free ABT group, the solubility and absorption rate were higher, and the bioavailability was improved by 2.25‐fold [9c] …”

Section: Introductionmentioning

confidence: 99%

“…β‐CD was extensively used due to its suitable cavity size and low price [14] . However, the native β‐CD has very low water solubility as well as hemolytic and nephrotoxic effects [9c,11b] . To improve the properties of β‐CD and expand its application in polar solvents such as water, the C2, C3 and C6 hydroxyl groups of β‐CD were modified [15] .…”

Section: Introductionmentioning

confidence: 99%

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Optimization, Characterization, Molecular Docking, and In Vitro Release of BBH/Lysine‐β‐cyclodextrin Inclusion Complex

Liu,

Zhou,

Ren

et al. 2023

ChemistrySelect

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Berberine hydrochloride (BBH) is an isoquinoline alkaloid, and its diverse bioactivities have been studied for decades. However, BBH exhibits poor solubility and low oral bioavailability, which hampers its potential therapeutic exploitation. In this study, hydrosoluble Lysine‐modified β‐cyclodextrin (Lys‐β‐CD) was synthesized. Then BBH‐Lysine‐β‐cyclodextrin inclusion complexes (BBH/Lys‐β‐CD IC) were prepared by the co‐deposition method and optimized using the Box‐Behnken design. In addition, phase solubility was studied and showed that BBH and Lys‐β‐CD can form inclusion complexes in a stoichiometric ratio of 1 : 1. The morphological characterizations exhibited that the IC had an irregular sheet and layered structure. The results of FTIR and 1H NMR revealed that BBH entered the Lys‐β‐CD cavity with non‐covalent interactions between host‐guest molecules. Furthermore, the binding pattern of BBH with the Lys‐β‐CD was investigated by molecular docking study. The release behavior of IC showed that BBH could be released slowly from the inclusion complex. Hence, the Lys‐β‐CD IC has broad application prospects in drug delivery and biomedical fields.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Optimization, Characterization, Molecular Docking, and In Vitro Release of BBH/Lysine‐β‐cyclodextrin Inclusion Complex

Liu,

Zhou,

Ren

et al. 2023

ChemistrySelect

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Inclusion Complexation of Flavonoids with Cyclodextrin: Molecular Docking and Experimental Study

Ming Liu,

Yun Zhou,

Qiang Jiang

et al. 2024

ChemistrySelect

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In our work, the inclusion ability and binding pattern of flavonoids (catechin, iso‐liquiritigenin, luteolin, puerarin, rutin, and curcumin) with β‐cyclodextrin (β‐CD) and curcumin (CUR) with CDs (α‐CD, β‐CD, γ‐CD, dimethyl‐β‐CD, Hydroxypropyl‐β‐CD, and glucosyl‐β‐CD) were studied by molecular docking. The results showed that CUR among the six flavonoids was more likely to form stable inclusion complexes with β‐CD, and the HP‐β‐CD is the most suitable for CUR inclusion among the 6 types of CD. Phase solubility studies showed that CUR with β‐CD or HP‐β‐CD, respectively, could form stable inclusion complexes in a stoichiometric ratio of 1 : 1. The CUR/β‐CD and CUR/HP‐β‐CD inclusion complexes (ICs) were prepared by freeze‐drying method. The successful preparation of IC was confirmed by SEM images, FT‐IR spectra, and TG‐DSC. The results of in vitro release showed that the release of CUR from IC prepared with β‐CD or HP‐β‐CD could be improved significantly, and the release effect of HP‐β‐CD was better than that of β‐CD. The inclusion with CD could be used to improve the solubility and bioavailability of CUR.

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Self-nanoemulsifying drug delivery system (SNEDDS) of docetaxel and carvacrol synergizes the anticancer activity and enables safer toxicity profile: optimization, and in-vitro, ex-vivo and in-vivo pharmacokinetic evaluation

Ateeq

Aalhate

Mahajan

et al. 2023

Drug Deliv. and Transl. Res.

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Formulation of inclusion complex of Abiraterone acetate with 2-Hydroxypropyl-Beta-Cyclodextrin: physiochemical characterization, molecular docking and bioavailability evaluation

Cited by 6 publications

References 39 publications

Optimization, Characterization, Molecular Docking, and In Vitro Release of BBH/Lysine‐β‐cyclodextrin Inclusion Complex

Optimization, Characterization, Molecular Docking, and In Vitro Release of BBH/Lysine‐β‐cyclodextrin Inclusion Complex

Inclusion Complexation of Flavonoids with Cyclodextrin: Molecular Docking and Experimental Study

Self-nanoemulsifying drug delivery system (SNEDDS) of docetaxel and carvacrol synergizes the anticancer activity and enables safer toxicity profile: optimization, and in-vitro, ex-vivo and in-vivo pharmacokinetic evaluation

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