Formulation of meloxicam gel for topical application: In vitro and in vivo evaluation

Bachhav, Yogeshwar; Patravale, Vandana

doi:10.2478/v10007-010-0020-0

Cited by 44 publications

(26 citation statements)

References 15 publications

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“…Limitations of the conventional drug solubilization strategies (Pace et al, 1999; Bachhav and Patravale, 2010) have led to exploration and invention of newer drug solublization techniques. Several colloidal and vesicular systems such as liposomes, microspheres, nanoparticles and microemulsions, have been studied for solubility enhancement and encapsulation of hydrophobic drugs.…”

Section: Strategies For Solubilization Of Hydrophobic Drugsmentioning

confidence: 99%

Impact of Dendrimers on Solubility of Hydrophobic Drug Molecules

et al. 2017

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Adequate aqueous solubility has been one of the desired properties while selecting drug molecules and other bio-actives for product development. Often solubility of a drug determines its pharmaceutical and therapeutic performance. Majority of newly synthesized drug molecules fail or are rejected during the early phases of drug discovery and development due to their limited solubility. Sufficient permeability, aqueous solubility and physicochemical stability of the drug are important for achieving adequate bioavailability and therapeutic outcome. A number of different approaches including co-solvency, micellar solubilization, micronization, pH adjustment, chemical modification, and solid dispersion have been explored toward improving the solubility of various poorly aqueous-soluble drugs. Dendrimers, a new class of polymers, possess great potential for drug solubility improvement, by virtue of their unique properties. These hyper-branched, mono-dispersed molecules have the distinct ability to bind the drug molecules on periphery as well as to encapsulate these molecules within the dendritic structure. There are numerous reported studies which have successfully used dendrimers to enhance the solubilization of poorly soluble drugs. These promising outcomes have encouraged the researchers to design, synthesize, and evaluate various dendritic polymers for their use in drug delivery and product development. This review will discuss the aspects and role of dendrimers in the solubility enhancement of poorly soluble drugs. The review will also highlight the important and relevant properties of dendrimers which contribute toward drug solubilization. Finally, hydrophobic drugs which have been explored for dendrimer assisted solubilization, and the current marketing status of dendrimers will be discussed.

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Section: Strategies For Solubilization Of Hydrophobic Drugsmentioning

confidence: 99%

Impact of Dendrimers on Solubility of Hydrophobic Drug Molecules

et al. 2017

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“…The increase in the diameter due to cream spreading was noted, which gives the spreadability of formulation. [2021]…”

Section: Methodsmentioning

confidence: 99%

Skin decontamination cream for radiological contaminants: Formulation development and evaluation

Khan

Rana

Ansari

et al. 2013

Int J Pharma Investig

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Background:Increased use of the radioactive materials in the field of research, medical, nuclear power plant, and industry has increased the risk of accidental exposure. Intentional use of the radioisotopes by terrorist organizations could cause exposure/contamination of a number of the population. In view of the accidental contamination, there is a need to develop self-usable decontamination formulations that could be used immediately after contamination is suspected.Materials and Methods:Present work was planned to optimize and develop self-usable radiation decontamination cream formulation. Various pharmaceutical parameters were characterized. 99mTc-sodium pertechnetate was used as radiocontaminant. Static counts were recorded before and after decontamination using single photon emission computed tomography.Results:Decontamination efficacy of the cream was found to be 42% ± 3% at 0-0.5 h after the exposure. Primary skin irritancy test was satisfactory as no erythema or edema was observed visually after 2 weeks of the formulation application.Conclusion:The decontamination studies proved the potential of EDTA to remove the radiological contaminants effectively.

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“…The volume difference between the carrageenan and control paws was used to evaluate the inflammatory response. Paw volume was measured using water plethysmometer immediately and 1, 2, 3, 4 and 5 h after carrageenan injection [16] .…”

Section: Determination Of Drug Content Spreadability Ph and Viscosimentioning

confidence: 99%

Topical Nanoemmigel Formulation of Boswellia serrata

Harsha¹,

Shreya²

2018

pharmaceutical-sciences

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Kathpalia and Shreya: Boswellia serrata NanoemmigelBoswellia serrata was formulated as topical analgesic and antiinflammatory nanoemmigel, which is a combination of a nanoemulsion and a nanomicellar system in a gel base. Nanoemulsion was formulated by microemulsion-template method by using probe sonication at 5 amp for 5 min. Particle size of nanoemulsion was found to be 141 nm and polydispersity index of 0.333. Nanomicelle was formulated at a ratio 1:1 of drug and surfactant and 1:10 of solvent and antisolvent using solvent evaporation method. The particle size and polydispersity index of the nanomicelle was found to be 31.07 nm and 0.205, respectively. Nanoemmigel was prepared by combining nanoemulsion and nanomicelle in the ratio 1:1 with Carbopol 974 as a gelling agent. The nanoemmigel prepared was a buff-coloured, opaque gel with smooth texture and good spreadability. Viscosity and drug content of the nanoemmigel was 50720 cps and 103±1.08 %, respectively. In vitro diffusion study of nanoemmigel showed 98.52±1.53 % drug permeation at the end of 5 h. The drug release mechanism of the nanoemmigel formulation can be explained using the Higuchi model. The steady state flux and permeability co-efficient of the nanoemmigel was found to be better than each of nanoemulsion gel and nanomicellar gel due to the utilization of both the pathways available to the drug for permeation through the skin. Improved therapeutic response was obtained as compared to nanoemulsion gel, nanomicellar gel, emulgel and also marketed topical product of Boswellia when examined for in vivo antiinflammatory and analgesic activity in animal models

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Formulation of meloxicam gel for topical application: In vitro and in vivo evaluation

Cited by 44 publications

References 15 publications

Impact of Dendrimers on Solubility of Hydrophobic Drug Molecules

Impact of Dendrimers on Solubility of Hydrophobic Drug Molecules

Skin decontamination cream for radiological contaminants: Formulation development and evaluation

Topical Nanoemmigel Formulation of Boswellia serrata

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