Formulation of quinoa oil-alginate loaded nanoemulsion and its anticancer efficacy as a therapy for chemically induced breast cancer

Abstract

Quinoa seeds (Chenopodium quinoa Willd.) have grown in interest due to their naturally occurring phytochemicals and antioxidants. It was stated that it has a powerful anticancer effect against human colorectal cancer. Gas chromatography-mass spectrometry was used to analyze the quinoa oil fatty acids. Sodium alginate was used as a loading agent to encapsulating the nanoemulsion, and its acute oral toxicity was assessed in rats. The nanoemulsion's ability to scavenge free radicals was evaluated using the DPPH radical-scavenging assay. The in vivo anticancer potential of the quinoa oil nanoemulsion on 7, 12-dimethylbenz (a) anthracene (DMBA)-induced breast cancer in rats was studied. Quinoa oil nanoemulsions were given daily to DMBA-breast cancer models for one month. Through the assessment of ROS, protein carbonyl, gene expression evaluation of anti-oncogenes, and histopathological analysis, the anticancer activity of the nanoemulsion was studied. Quinoa oil nanoemulsion administration signi cantly decreased the rise in serum ROS and PC levels brought on in breast cancer tissue. The quinoa oil nanoemulsion alleviated the mRNA expression levels of antioncogenes in breast cancer tissue. As well, nanoemulsions improved breast tumor tissue architecture. Conclusion:We can infer from the results that quinoa oil nanoemulsion can obstruct the breast cancer cells of the rats.