Formulation of selenium nanoparticles encapsulated by alginate-chitosan for controlled delivery of Vibrio Cholerae LPS: A novel delivery system candidate for nanovaccine

Bagheri-Josheghani, Sareh; Bakhshi, Bita

doi:10.1016/j.ijbiomac.2022.03.087

Cited by 17 publications

(2 citation statements)

References 57 publications

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“…The immunomodulatory effects of selenium nanoparticles were assessed in this work, producing long-lasting humoral and cellular immunological responses to boost vaccination-induced immune response [ 7 – 9 ]. Nanoselenium is less toxic as well as more suitable for biological use than sodium selenite, and it also has a number of helpful features, including excellent antioxidant activity, adsorption strength, surface activity, and catalytic performance [ 10 – 13 ].…”

Section: Introductionmentioning

confidence: 99%

Selenium nanoparticles effect on foot and mouth disease vaccine in local Awassi breed male lambs

Hamzah,

Dawood

2024

J Adv Vet Anim Res

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Objective: The goal of this research was to evaluate where selenium nanoparticles impact the activity of antibodies in immunized lambs with foot and mouth vaccines by modulating the immune system. Materials and Methods: Two groups of lambs of 3–4 months of age were injected with 1 ml of ARRIAH-VAC vaccine intramuscularly in the neck, five Lambs were given selenium nanoparticles (size 100 nm) oral administration of selenium nano dose of 0.1 mg/kg of body mass once every day for sixty days considered as group one (G1) while the other five used as control Group 2 (G2). Results: This resulted in the establishment of an immune response, as evidenced by a rise in antibody titer in the blood using the ELISA test for three serotypes A, O, and Asia 1, when sele¬nium nanoparticles were given orally at a dose of 0.1 mg/kg body weight after immunization, we noticed a significant (p >0:05) selenium nano group increase in IgG response in all immunized groups in contrast to lambs that had only received the foot-and-mouth disease vaccine Conclusion: We have demonstrated that selenium nanoparticles administered orally significantly enhance immune responses while also increasing body weight.

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Section: Introductionmentioning

confidence: 99%

Selenium nanoparticles effect on foot and mouth disease vaccine in local Awassi breed male lambs

Hamzah,

Dawood

2024

J Adv Vet Anim Res

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“…Selenium is an indispensable micronutrient in living organisms and plays an important role in the prevention of cancer ( Sun et al, 2016 ), diabetes ( Liu et al, 2018b ), and immune modulation capabilities ( Bagheri-Josheghani and Bakhshi, 2022 ). At same time, selenium is involved in the antioxidant defense systems of the liver and plays an important role in protecting against oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

Ameliorative effect of Berberidis radix polysaccharide selenium nanoparticles against carbon tetrachloride induced oxidative stress and inflammation

Gao

Liu²,

Han³

et al. 2022

Front. Pharmacol.

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Berberidis radix polysaccharide (BRP) extracted as capping agents was applied to prepare BRP-selenium nanoparticles (BRP-SeNPs) in the redox reaction system of sodium selenite and ascorbic acid. The stability and characterization of BRP-SeNPs were investigated by physical analysis method. The results revealed that BRP were tightly wrapped on the surface of SeNPs by forming C-O⋯Se bonds or hydrogen bonding interaction (O-H⋯Se). BRP-SeNPs presented irregular, fragmented and smooth surface morphology and polycrystalline nanoring structure, and its particle size was 89.4 nm in the optimal preparation condition. The pharmacologic functions of BRP-SeNPs were explored in vitro and in vivo. The results showed that BRP-SeNPs could heighten the cell viabilities and the enzyme activity of GSH-Px and decrease the content of MDA on H2O2-induced AML-12 cells injury model. In vivo tests, the results displayed that BRP-SeNPs could increase the body weight of mice, promote the enzyme activity like SOD and GSH-Px, decrease the liver organ index and the hepatic function index such as ALT, AST, CYP2E1, reduce the content of MDA, and relieve the proinflammation factors of NO, IL-1β and TNF-α in CCl4-induced mice injury model. Liver tissue histopathological studies corroborated the improvement of BRP-SeNPs on liver of CCl4-induced mice. The results of Western blot showed that BRP-SeNPs could attenuate oxidant stress by the Nrf2/Keap1/MKP1/JNK pathways, and downregulate the proinflammatory factors by TLR4/MAPK pathway. These findings suggested that BRP-SeNPs possess the hepatoprotection and have the potential to be a green liver-protecting and auxiliary liver inflammation drugs.

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Overview of Nanovaccines and Nanoadjuvants

Soni,

Chugh,

Sharma

et al. 2024

Nanotechnology Theranostics in Livestock Diseases and Management

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Formulation of selenium nanoparticles encapsulated by alginate-chitosan for controlled delivery of Vibrio Cholerae LPS: A novel delivery system candidate for nanovaccine

Cited by 17 publications

References 57 publications

Selenium nanoparticles effect on foot and mouth disease vaccine in local Awassi breed male lambs

Selenium nanoparticles effect on foot and mouth disease vaccine in local Awassi breed male lambs

Ameliorative effect of Berberidis radix polysaccharide selenium nanoparticles against carbon tetrachloride induced oxidative stress and inflammation

Overview of Nanovaccines and Nanoadjuvants

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