Formulation of Solid Lipid Nanoparticles Loaded Thermo-reversible Nasal In-situ Gel Containing Hibiscus Rosa Sinensis (L.) Extract

Thorat, Yogesh; Shirure, Parikshit; Mirza, Naushad N.; Hosmani, Avinash H.

doi:10.46624/ajptr.2019.v9.i3.013

Cited by 3 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Poloxamers were added to cold distilled water with continuous agitation and kept overnight at 6 to 8 ⁰C until a clear solution was obtained. Quercus infectoria gall extract and mucoadhesive polymer (Formulation Tables 1 and 2) were added to the Poloxamer solution with constant stirring 19 . Color: The color was observed visually against a black background.…”

Section: Formulation Of Gel: Formulation Of Thermosensitive Mucoadhesivementioning

confidence: 99%

Untitled

2023

IJPSR

View full text Add to dashboard Cite

Presently, the surge in the consumption of herbal formulations is encouraged by several factors; the main factor is that they are relatively safe and effective. Plant extracts are considered an alternative source of synthetic drugs and are expected to produce promising results for treating several diseases. The present study aimed to formulate and evaluate antibacterial thermosensitive mucoadhesive gel containing Quercus infectoria gall extract and synthesize and characterize the silver nanoparticles by using Quercus infectoria gall extract. For extraction, water and ethanol were used as a solvent. The major constituents of the extract are tannic acid, gallic acid, ellagic acid, and these three constituted showed synergistic antibacterial activity. Formulated gel delivered the drug for more than 4 hr. The batch F5 optimized with good viscosity, spreadability and extrudability, mucoadhesive strength, release of drug is more, and the gel is stable; hence it is used for further evaluation like in-vitro skin irritation study and in-vitro antibacterial test. The formulated gel was not irritant and showed antibacterial activity greater than the marketed gel formulation containing tannic acid as an active pharmaceutical ingredient to treat mouth ulcers and gum disorders. The successful synthesis of silver nanoparticles from the extract of Quercus infectoria gall act as a reducing and capping agent. AgNPs exhibit significant antibacterial activity.

show abstract

Section: Formulation Of Gel: Formulation Of Thermosensitive Mucoadhesivementioning

confidence: 99%

Untitled

2023

IJPSR

View full text Add to dashboard Cite

show abstract

Formulation and Evaluation of Solid Lipid Nanoparticles containing Kappaphycus alvarezii Extract in A Cosmetic Gel

Xin

Chellathurai

Kumar

et al. 2022

RJPT

View full text Add to dashboard Cite

Objectives: The objective of the research was to prepare and evaluate the cosmetic gel containing SLNs of Kappaphycus alvarezii chloroform extract to localize the extract topically to exert its antimicrobial properties. Methodology: The antimicrobial activity evaluation for the chloroform, methanol, and aqueous K. alvarezii extracts were carried out using disc-diffusion agar plate method. The extract with maximum antimicrobial action was selected for the preparation of SLNs. Pre-formulation studies using ATR-FTIR spectrophotometer was carried out to check the compatibility of the extract with excipients in the range of 400–4000 cm−1.The SLNs were prepared by the film hydration technique with ultrasonication. The dried SLNs were evaluated for its physical characteristics, zeta potential and for the duration taken to release the encapsulated extract for the antimicrobial action. Carbopol and HPMC were chosen as the gelling agent after compatibility studies with nanoparticle dispersions.The extract loaded SLNs based gel was analysed for its pH, visual appearance, and in-vitro drug release. Results: Chloroform extract of K. alvarezii (120μg) showed maximum antimicrobial activity with cloudy and blurry zone of inhibition. The zone of inhibition was smaller for SLNs when compared to the extract. This was due to the low diffusion of encapsulated drug through the outer lipid layer of SLNs. SLNs showed a zeta potential ranging between –11.0 to –37.4mV. The formulated gel containing solid lipid nanoparticles of chloroform extract of K. alvarezii had an average pH value of 5.37, which was suitable to be used on human skin. The maximum drug release was 60.28% for over a period of 25 hours. Conclusion: In this study algal extracts were successfully encapsulated within the SLNs and when applied topically the SLNs could reside on the surface of the skin for localized action as evident from the drug release study.The zeta potential obtained for the SLNs was approximately within the limit of –30mV that yields a formulation with fairly good physical stability.

show abstract

In Situ Gelling Gastro-retentive Raft Containing Ficus racemosa Fruit Extract: A Promising Approach to Treat GERD

Shripad Thorat,

Pralhad Bagewadikar,

Mali

et al. 2023

RJPT

View full text Add to dashboard Cite

Gastro-retentive drug delivery system has been widely used to prolong retention of dosage forms in stomach. Amongst various formulations and approaches, the raft formulations sustain the drug release as well as prolonged gastric retention, along with the added advantage of liquid dosage forms. The present study was an attempt to formulate and evaluate Raft forming floating gel for the extract of Ficus racemosa unripe fruit also known as Udumbar or Audumbar which is recognized for the treatment of ulcerative diseases in Ayurveda. To prepare the raft formulation natural polymers such as Gellan Gum, Xanthan Gum and Guar Gum were used along with gas forming ingredients. The formulations were prepared using 32 factorial design. The raft formulations are expected to prolong the retention of the medicinally active extract in stomach for longer duration of action. The evaluation was carried out for floating behavior, gel strength, viscosity, and in vitro dissolution for the gastro-retentive gels. The formulations were found to have floating duration upto 05 hr with a sustained release of active medicament.

show abstract

Formulation of Solid Lipid Nanoparticles Loaded Thermo-reversible Nasal In-situ Gel Containing Hibiscus Rosa Sinensis (L.) Extract

Cited by 3 publications

References 0 publications

Untitled

Untitled

Formulation and Evaluation of Solid Lipid Nanoparticles containing Kappaphycus alvarezii Extract in A Cosmetic Gel

In Situ Gelling Gastro-retentive Raft Containing Ficus racemosa Fruit Extract: A Promising Approach to Treat GERD

Contact Info

Product

Resources

About