Formulation, optimization, and evaluation of a transdermal patch of heparin sodium

Patel, Rakesh P.; Gaiakwad, Dipika R.; Patel, Nikunjana A.

doi:10.5582/ddt.2014.01030

Cited by 10 publications

(6 citation statements)

References 23 publications

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“…Matrix type of transdermal patch was developed using heparin sodium along with 30% (w/w) PEG 400 LR using different hydrophilic polymers. Highest flux was observed for the formulation with 1.369-fold increase in permeation of the drug through the rat skin (Patel et al, 2014).…”

Section: Polyethylene Glycolmentioning

confidence: 97%

Advancements of Polymer-Based Transdermal Drug Delivery Systems in Drug Bioavailability and Patient Compliance in United States

2024

J Angiotherapy

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Transdermal drug delivery system (TDDS) helps in overcoming drug molecule barriers such as particle size, lipophilicity, permeability, and transports the medication directly to the blood circulation by employing physical and chemical penetration enhancers using polymers. The use of skin as a drug delivery route is challenging due to the stratum corneum's barrier properties that restrict the therapeutic bioavailability of the medications. Both, natural and synthetic polymers are used in TDDS to transport the medication into circulation via diffusion, and swelling control. TDDS is generally achieved by using transdermal patches containing one or more pharmaceutical active entities that are placed on unbroken skin for delivering active entities directly to the bloodstream by crossing the skin barrier. TDDS is the trendiest -delivery system as it is painless, non-invasive, self-administrative, avoids hepatic first-pass metabolism, and delivers poorly soluble drugs and increases the bioavailability. An overview of TDDS is provided in this review article, including its advantages over traditional dosage forms, limitations, different components of transdermal patches, modern techniques as well as transdermal products available in US market.

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Section: Polyethylene Glycolmentioning

confidence: 97%

Advancements of Polymer-Based Transdermal Drug Delivery Systems in Drug Bioavailability and Patient Compliance in United States

2024

J Angiotherapy

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“…The in-vitro drug that released assays from topical preparations was carried out to characterize the final product's performance as a quality assessment method and justify post-approval alterations and scale-up [42]. Vertical diffusion cells are an in-vitro test model for predicting bioavailability and bioequivalence by measuring drug release from semisolid and transdermal dosage forms [9,[22][23][24]. This release test can use synthetic membranes, such as nitrocellulose.…”

Section: Release Diffusion Ratementioning

confidence: 99%

“…Oleic acid (OA) is a fatty acid group that can increase drug penetration by producing a permeable defect in SC lipids due to oleic acid's cis double bond. That enables it to deliquesce itself rather than disperse uniformly in natural skin fats [18], [19], [21]- [23].…”

Section: Introductionmentioning

confidence: 99%

Effect of Isopropyl Myristate and Oleic Acid as the Penetration Enhancer on Transdermal Patch: Characteristics and In-Vitro Diffusion

et al. 2023

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“…[17,22] Stability Study of Optimized Batch In order to determine the change in physicochemical parameters and in vitro release profile on storage, a stability study was carried out. [23] Stability study for the optimized formulation of NFT loaded NLCs was carried out. NLCs were packed and sealed in class-I glass vials.…”

Section: Tem and Xrpd Study Of Optimized Batchmentioning

confidence: 99%

Formulation, optimization and characterization of nanostructured lipid carrier of nitrofurantoin

Goswami¹,

Patel²

2020

Int. J. Pharm. Sci. Drug Res.

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Nitrofurantoin is effective against many urinary tract pathogens. It acts as bacteriostatic and/or bactericidal by inhibiting DNA-RNA protein& cell wall synthesis. Nanostructured Lipid Carriers (NLCs) of NFT was prepared by Hot Homogenization Process. Glyceryl Monostearate and Miglyol 812 were heated at 80ºC temperature on hot plate. In the melted lipid, drug was added with continuous stirring at high speed homogenization. Formulation NLC12B has % Entrapment efficiency 89.1 ± 0.5, PDI 0.11 ± 0.01 and mean particle size 237 ± 7nm represents narrow particle size distribution. Spherical feature of NLCs with better uniformity without aggregation of Nitrofurantoin loaded NLC was confirmed by TEM. Moreover, efficient miscibility of drug in lipids was confirmed by the absence of intense and characteristic peak of NFT in XRPD. After 6 month storage at 2-8°C there was no significant changes in the PDI as well as mean particle size.

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Formulation, optimization, and evaluation of a transdermal patch of heparin sodium

Cited by 10 publications

References 23 publications

Advancements of Polymer-Based Transdermal Drug Delivery Systems in Drug Bioavailability and Patient Compliance in United States

Advancements of Polymer-Based Transdermal Drug Delivery Systems in Drug Bioavailability and Patient Compliance in United States

Effect of Isopropyl Myristate and Oleic Acid as the Penetration Enhancer on Transdermal Patch: Characteristics and In-Vitro Diffusion

Formulation, optimization and characterization of nanostructured lipid carrier of nitrofurantoin

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