Formulation Optimization and Evaluation of Flurbiprofen Emulgel

Abstract

Objective: The objective of the present study was to formulate flurbiprofen (FLB) emulgel, evaluation of the formulations and the selection of an optimized formulation through in vitro drug release and drug content studies. Flurbiprofen is a non-steroidal anti-inflammatory drug (NSAID) requiring frequent administration and its chronic intake can lead to systemic side effects like gastric irritation and GI bleeding. The development of a dermal drug delivery system can overcome these side effects.
 Methods: The emulgel formulations were produced using different combinations of oil and emulsifying agents. Carbopol 940 was used as a gelling agent. The prepared emulgels were evaluated for general appearance, pH, spreadability, extrudability, drug content, in vitro drug release, average globule size and viscosity.
 Results: Optimized formulation F7 showed a better in vitro drug release compared to the marketed gel preparation. The stability study for the optimized formulation was carried out at 25 °C/60 % RH for 3 mo and the emulgel was found to be stable concerning the physical appearance, pH and drug content.
 Conclusion: The study revolved around the formulation of emulgel containing Flurbiprofen for dermal delivery of the drug. Emulgel was formulated with the purpose to enhance the permeation of poorly water-soluble drug FLB. The study concluded that the optimized emulgel containing FLB exhibited better in vitro drug release profile compared to the marketed formulation.

The Use of Carrot Seed Oil (Daucus Carota L.) to Formulate Nanoemulgels as an Effective Natural Sunscreen and Skin Anti-Aging

“…In the water phase, methylparaben and propylparaben as preservatives were dissolved in distilled water, then heated by using the hot plate (Fisons); this solution was added Tween 80 and stirred at 3000 rpm by magnetic stirrer (Boeco, Germany) for 8 h. The oil phase was mixed into the water phase and stirred at 3000 rpm with a magnetic stirrer (Boeco, Germany) for 8 h, then sonicated for 30 s by ultrasonicator (Ultrasonic Cleaner Branson 1510 E-MT, USA) until a transparent nanoemulsion was formed. Carbopol 940 was dispersed in pure water and added with TEA to pH-6.5 to obtain a gel base of 1% Carbopol 940 solution [15]. Nanoemulgels were prepared by mixing the obtained nanoemulsion containing carrot seed oil with a gel base of 1% Carbopol 940 (ratio of nanoemulsion and gel base 4:1), then stirred using a magnetic stirrer at 3000 rpm for 10 h and ultrasonicated for 2 h until a transparent nanoemulgels were produced [16].…”