Formulation strategies for the oral delivery of probiotics: a review

doi:10.33263/briac95.327333

Cited by 4 publications

(2 citation statements)

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“…Probiotics have been introduced in the oral cavity in the form of oral dosage forms such as capsules, tablets, chewing gum, lozenges, powder and nanoparticles. 45,46…”

Section: Types Of Lactobacillus Probiotics Preparationsmentioning

confidence: 99%

Biotherapeutic Potential of Lactobacillus Probiotic Strains on Streptococcus mutans Biofilm in Dental Caries–Pathogenesis Revisited

Vedam,

Sabesan,

Adhikary

et al. 2023

Ind. J. Pharm. Edu. Res

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This review gives an insight on the anticariogenic role of each of the individual strains of Lactobacillus probiotics on Streptococcus mutans bacterium associated with dental caries and also attempts to emphasize the commercially approved oral probiotic products using Lactobacillus strains exclusively, against dental caries. Probiotics in bacteriotherapy have been an emerging strategy in the management of 'Dental caries' . Probiotics, protect the tooth surfaces from the competing microbial pathogens in the mouth. Lactobacillus species despite its acidogenicity has taken a breakthrough in the intervention of dental caries due to its acid buffering capacity with dairy product administration and as late colonizers for dental caries. This article compiled the pathogenesis of individual Lactobacillus strains of probiotics in a well-illustrated manner on S. mutans and also the list of the commercial products of oral probiotics with exclusive lactobacillus strains on S. mutans and its effect on dentistry. Probiotic formulations and recent strategies with future perspectives are emphasized. Also, the role of individual Lactobacillus strains and the associated commercial products against dental caries have been compiled to give additional knowledge regarding the changing strategic approach towards dental caries from the laboratory and clinician point of view. Restorative treatment strategies for dental caries act against both disease causing microbial species and commensal of the oral cavity resulting in undesirable adverse effects. As there is a need to switch to probiotics as a natural therapeutic approach, this review has sheds light on proposed pathogenesis, commercial products and future perspective that will promote researchers to work on new Lactobacillus probiotic formulations with greater efficacy in overcoming the emerging multispecies generating with time in caries.

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“…Probiotics have been introduced in the oral cavity in the form of oral dosage forms such as capsules, tablets, chewing gum, lozenges, powder and nanoparticles. 45,46…”

Section: Types Of Lactobacillus Probiotics Preparationsmentioning

confidence: 99%

Biotherapeutic Potential of Lactobacillus Probiotic Strains on Streptococcus mutans Biofilm in Dental Caries–Pathogenesis Revisited

Vedam,

Sabesan,

Adhikary

et al. 2023

Ind. J. Pharm. Edu. Res

View full text Add to dashboard Cite

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“…Manipulation of gut microbiome in mCRC patients may represent an effective solution for the pre-existing dysbiosis. Along with diet, the main therapeutic methods which modify the gut microenvironment are fecal microbiota transplantation (FMT) and the use of probiotics, prebiotics, postbiotics and synbiotics [86][87][88][89][90][91].…”

Section: Gut Microbiome Manipulation In Mcrc Patientsmentioning

confidence: 99%

The Impact of Long-Term Antibiotic Therapy of Cutaneous Adverse Reactions to EGFR Inhibitors in Colorectal Cancer Patients

Mihai

Ion

Giurcăneanu

et al. 2021

JCM

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Colorectal cancer (CRC) is an important public health issue, in terms of incidence and mortality, with approximately 1.8 million new cases reported worldwide in 2018. Advancements in understanding pathophysiological key steps in CRC tumorigenesis have led to the development of new targeted therapies such as those based on epidermal growth factor receptor inhibitors (EGFR inhibitors). The cutaneous adverse reactions induced by EGFR inhibitors, particularly papulopustular rash, often require long-term antibiotic treatment with tetracycline agents (mostly minocycline and doxycycline). However, this raises several issues of concern: possible occurrence of gut dysbiosis in already vulnerable CRC patients, selection of highly antibiotic resistant and/or virulent clones, development of adverse reactions related to tetracyclines, interference of antibiotics with the response to oncologic therapy, with a negative impact on disease prognosis etc. In the context of scarce information regarding these issues and controversial opinions regarding the role of tetracyclines in patients under EGFR inhibitors, our aim was to perform a thorough literature review and discuss the main challenges raised by long-term use of tetracyclines in advanced CRC patients receiving this targeted therapy.

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