Forskolin G

Abstract

In the mol­ecule of the title compound (systematic name: 1α‐hydr­oxy‐6β,7β‐diacet­oxy‐8,13‐epoxy­labd‐14‐en‐11‐one), C24H36O7, rings A and B adopt chair conformations, while ring C has a twist–boat conformation. The crystal structure is stabilized by inter­molecular O—H⋯O and C—H⋯O hydrogen bonds, linking the mol­ecules into networks approximately parallel to the (110) plane.

Crystal structure and Hirshfeld surface analysis of 2-oxo-13-epi-manoyl oxide isolated from Sideritis perfoliata

“…The closest related compound is 2--hydroxymanoyl oxide [systematic name: 3,4a,7,7,chromen-9-ol] also isolated from Sideritis perfoliata (UVEVOI; Ç elik et al, 2016). Other compounds include, Forskolin G (systematic name: 1-hydroxy-6,7-diacetoxy-8,13-epoxylabd-14-en-11-one; CSD refcode ADATUV; Shan et al, 2006), l,5-dihydroxymanoyl oxide, a novel diterpene from Satureja gilliesii (RASXUE; Manríquez et al, 1997), 4ahydroxy-18-normanoyl oxide (GAPZUT; Ybarra et al, 2005), jhanol (GAQBAC; Ybarra et al, 2005), 1R,11S-dihydroxy-8R,13R-epoxylabd-14-ene (LUDTOU; Stavri et al, 2009) and (À)-paniculatol (NEJHAL; Briand et al, 1997).…”