Forsterite/nano-biogenic hydroxyapatite composites for biomedical applications

Abstract

Recently, silicate materials have received attention as materials with promising applications in the bioceramics field. A recent study aimed to investigate the effect of forsterite (Mg 2 SiO 4) addition to biogenic hydroxyapatite, Ca 10 (PO 4) 6 (OH) 2 , on the phase formation, physical and mechanical properties, and biocompatibility of the produced composites. Different proportions of forsterite, 10 to 40 mass%, were added to hydroxyapatite obtained from fish bones to prepare the target composites. Various techniques, such as X-ray diffraction analysis (XRD), scanning electronic microscope (SEM), transmission electronic microscope (TEM), mechanical strength measurements and in vitro studies, were carried out to evaluate the composite properties. The results indicate that the addition of 20 to 40 mass% forsterite led to the transformation of forsterite into protoenstatite and the formation of Mg-rich whitlockite at the expense of hydroxyapatite. It is concluded that 20 mass% forsterite is the optimum addition amount to enhance the physical and mechanical properties of the produced composites. The cell culture tests and in vitro studies agree with the abovementioned results.

UV-assisted synthesis of hydroxyapatite from eggshells at ambient temperature: cytotoxicity, drug delivery and bioactivity

“…In recent years, the application of synthesized biomaterials in bone and dentistry elds has received signicant attention and notable efforts have been reported for the synthesis of biomaterials via different routes using various sources. [1][2][3][4][5] In particular, hydroxyapatite [Ca 10 (PO 4 ) 6 (OH) 2 ], which retains a close chemical similarity to the mineral phase of bone, is ranked highly as one of the most promising biomaterials. [5][6][7] It is wellknown that this biomaterial possesses rst-rate biocompatibility, biodegradability, bioactivity, nontoxicity and non-inammatory characteristics which demonstrate its extensive use in various biomedical elds, for example, as a bone cavity lling material, for drug delivery applications, bone substitutes, implant components, coatings on implants, the treatment of hyperthermia in cancer patients, dental materials and so on.…”

Review on the Biocompatibility and Bioactivity of Forsterite: In Vitro and in Vivo studies

“…All discussed papers showed forsterite to be biocompatible with no cytotoxic effect and to possess a good bioactivity. Some research groups went even further, by studying forsterite-based composite materials [70,[112][113][114][115][116][117][118]. These composites combine the properties of forsterite with those of other biocompatible materials both inorganic such as hydroxyapatite, wollastonite, diopside, as well as polymers like polycaprolactone, in an attempt to tailor new possibilities for medical implant design.…”

Hydroxyapatite fortified mango mousse: Formulation, characterization, and sensory data evaluation using fuzzy logic

“…This material is considered one of the most used elements in porous bone regeneration, mainly because of its affinity to bone tissues (Bozorgi et al., 2021). The unique combination of tailorability, nanostructure, and biocompatibility makes animal bones‐derived HAp an attractive biomimetic calcium source for various bone‐related applications (Naga et al., 2020). Apart from that, HAp also has many desired biocompatibility traits such as non‐toxicity, no inflammatory effects, and immunologic responses that can be enhanced (Alhussary et al., 2020).…”