Fortified tuna bone powder supplementation increases bone mineral density of lactating rats and their offspring

Suntornsaratoon, Panan; Charoenphandhu, Narattaphol; Krishnamra, Nateetip

doi:10.1002/jsfa.8688

Cited by 21 publications

(15 citation statements)

References 35 publications

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“…Fish bones are rich in calcium with high bioavailability (Malde et al, ). Therefore, some researchers have focused on the utilization of calcium in fish bones (Nawaz et al, ; Suntornsaratoon, Charoenphandhu, & Krishnamra, ). Despite the increasing efforts to obtain new products from this waste, the majority are still thrown away or used as animal food (Alkaya & Demirer, ).…”

Section: Introductionmentioning

confidence: 99%

Small‐size effect on physicochemical properties of micronized fish bone during heating

Jiang

Zhang

Yin

et al. 2020

J Food Process Preserv

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Abbreviations: FT-IR, Fourier transform infrared spectroscopy; MFB, micro-scaled fish bones; NFB, nano-scaled fish bones; XRD, X-ray diffraction AbstractThe aim of the study is to investigate physicochemical properties of nano-scaled fish bone (NFB) and micro-scaled fish bone (MFB) during heating and improve their valorization by promoting their calcium release. For MFB, heating promoted its calcium release (from 0.7% to 2.2%) and solubility (from 4.6% to 11%) mainly by reducing the particle size (from 20.51 to 17.85 μm). However, the FT-IR and XRD of MFB spectra showed small change during heating. For NFB, heating hardly changed its particle size but further destroyed the crystal and chemical structure of NFB. The solubility was significantly increased from 9.8% to 14.0%. After heating at 90°C, the sharper diffraction peaks of hydroxyapatite were also observed. The calcium release was significantly promoted from 9.0% to 14%. The results showed heating could more effectively promote the calcium release of fish bones when the particle size was reduced to nanoscale. Practical applicationsGrass carp is the most productive freshwater fish in China. Fish bones are the main by-product from fish processing. Fish bones can be added to food as a natural calcium sources. The aims of our research are to improve the calcium release of fish

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Section: Introductionmentioning

confidence: 99%

Small‐size effect on physicochemical properties of micronized fish bone during heating

Jiang

Zhang

Yin

et al. 2020

J Food Process Preserv

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“…18 , 31 By contrast, calcium supplementation does not enhance the trabecular bone structure in lactating rats. 32 Surprisingly, annatto tocotrienol did not act synergistically with calcium carbonate in this study to further enhance its effects on bone microstructure. A previous report indicated that annatto tocotrienol prevents the deterioration of bone microstructure in animal models of bone loss induced by testosterone deficiency, 18 , 19 , 31 oestrogen deficiency 33 and metabolic syndrome.…”

Section: Discussionmentioning

confidence: 52%

“…Similarly, calcium supplementation of the rat dams does not improve bone strength of pups. 32 This observation contradicted the findings of Mohamad et al (2018) that calcium in drinking water improves the femoral load and Young’s modulus of rats with testosterone deficiency induced by buserelin. 18 Annatto tocotrienol also improves the bone strength of the rats in some models of osteoporosis 17 , 18 but is ineffective in this case.…”

Section: Discussionmentioning

confidence: 83%

“…31 However, calcium supplementation reduces erosion surface but not osteoblast and osteoclast numbers in lactating rats. 32 Previous studies found that annatto tocotrienol improves bone cellular indices in various animal models of bone loss. 17,31,37,38 Interaction between annatto tocotrienol and pantoprazole might exist, which hinders the beneficial actions of annatto tocotrienol on bone cells.…”

Section: Dovepressmentioning

confidence: 99%

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<p>Effects of Calcium and Annatto Tocotrienol Supplementation on Bone Loss Induced by Pantoprazole in Male Rats</p>

Chin

Thong

Kamalulloh

et al. 2020

DDDT

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Prolonged use of proton pump inhibitors may cause bone loss, and limited therapeutic agents are available to prevent this skeletal side effect. The combination of annatto tocotrienol, a bone anabolic agent, with calcium presents a novel strategy to prevent bone loss caused by proton pump inhibitors. This study aims to compare the effects of calcium alone and in combination with annatto tocotrienol or vitamin D 3 (Caltrate Plus) in preventing bone loss caused by pantoprazole. Methods: Three-month-old Sprague Dawley male rats (n=30) were randomised into five groups (n=6/group). Bone loss was induced by pantoprazole (3 mg/kg p.o.) in four groups, and they were treated concurrently with either calcium carbonate (77 mg p.o.), calcium carbonate (77 mg p.o.) plus annatto tocotrienol (60 mg/kg p.o.) or Caltrate Plus (31 mg p.o.) for 60 days. The rats were euthanised at the end of the experiment, and their femurs were harvested for X-ray micro-computed tomography, bone cellular histomorphometry and bone mechanical strength analysis. Results: Pantoprazole caused significant deterioration of trabecular bone microstructures but did not affect other skeletal indices. Calcium supplementation with or without annatto tocotrienol prevented the deterioration of trabecular microstructures at the femur but did not improve other skeletal indices. Annatto tocotrienol did not enhance the skeletal actions of calcium, whereas Caltrate Plus did not affect the bone health indices in these rats. Conclusion: Calcium supplementation per se can prevent the deterioration of bone trabecular microstructures in rats receiving long-term treatment of pantoprazole.

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“…Malde et al (2010) later conducted a double-blind randomized crossover trial and found that calcium from enzyme-treated salmon and cod bones was well absorbed by healthy young men. Besides, it was also reported that fortified tuna bone powder supplementation increased bone mineral density and improved the maternal bone microstructure of lactating rats and their offsprings (Suntornsaratoon et al, 2018). Therefore, it is possible to provide a novel nutraceutical with high bioavailability for Ca and Ca-fortified food supplements, such as fruit juice or Ca-rich foods, and as alternatives to dairy products (Jung et al, 2006;Nemati et al, 2016).…”

Section: Application Of Fish Bone Minerals In Functional Food/nutracementioning

confidence: 99%

Utilization of marine by-products for the recovery of value-added products

Shahidi¹,

Varatharajan²,

Han³

et al. 2019

Journal of Food Bioactives

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The world fisheries resources have exceeded 160 million tons in recent years. However, every year a considerable amount of total catch is discarded as by-catch or as processing leftovers, and that includes trimmings, fins, frames, heads, skin, viscera and among others. In addition, a large quantity of processing by-products is accumulated as shells of crustaceans and shellfish from marine bioprocessing plants. Recognition of the limited marine resources and the increasing environmental pollution has emphasized the need for better utilization of the by-products. Marine by-products contain valuable protein and lipid fractions, minerals, enzymes as well as many other components. The major fraction of by-products are used for feed production-in making fish meal/oil, but this has low profitability. However, there are many ways in which the fish and shellfish waste could be better utilized, including the production of novel food ingredients, nutraceuticals, pharmaceuticals, biomedical materials, fine chemicals, and other value-added products. In recent times, much research is conducted in order to explore the possible uses of different by-products. This contribution primarily covers the characteristics and utilization of the main ingredients such as protein, lipid, chitin and its derivatives, enzymes, carotenoids, and minerals originating from marine by-products.

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Fortified tuna bone powder supplementation increases bone mineral density of lactating rats and their offspring

Cited by 21 publications

References 35 publications

Small‐size effect on physicochemical properties of micronized fish bone during heating

Small‐size effect on physicochemical properties of micronized fish bone during heating

<p>Effects of Calcium and Annatto Tocotrienol Supplementation on Bone Loss Induced by Pantoprazole in Male Rats</p>

Utilization of marine by-products for the recovery of value-added products

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