Fortlaufende Bestimmung der Hautdurchblutung am Menschen mit einem elektrischen W�rmeleitmesser

Hensel, Herbert; Bender, F

doi:10.1007/bf00362177

Cited by 116 publications

(17 citation statements)

References 18 publications

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“…All were given soluble insulin (Hoechst) 0.1 i.u./kg I.v., receiving on the average 8 i.u. Skin blood flow was recorded with a thermal conductivity meter (Hensel & Bender, 1956) from the middle third of the forearm. Muscle blood flow was followed with a calorimetric probe (Hensel & Ruef, 1954;Hensel & Bock, 1955) in the brachioradialis-extensor group of muscles.…”

Section: Methodsmentioning

confidence: 99%

Muscle and skin blood flow in the human forearm during insulin hypoglycaemia

Allwood¹,

Hensel²,

Papenberg³

1959

The Journal of Physiology

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Section: Methodsmentioning

confidence: 99%

Muscle and skin blood flow in the human forearm during insulin hypoglycaemia

Allwood¹,

Hensel²,

Papenberg³

1959

The Journal of Physiology

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“…Partly invasive methods, too, usually provide only information about relative changes. By means of the heat-conducting probe introduced by Hensel (30,31,32) and the heat-clearance device for the skin (27,28,29), changes in muscle and skin blood flow in an extremity can be measured independently of each other, however, measurements of absolute blood flow are not possible. Moreover, the heat-conducting probe has to be inserted into the muscle, and therefore it cannot be excluded with certainty that the test results are influenced by local hyperemia due to injury to the measuring site (1,49).…”

Section: Introductionmentioning

confidence: 99%

Noninvasive, quantitative determination of muscle blood flow in man by a combination of venous-occlusion plethysmography and computed tomography

Weber¹,

Anlauf²,

Serdarevic³

1988

Basic Res Cardiol

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Because of the lack of non-invasive methods for measuring muscle blood flow, quantitative investigations of blood flow in the skeletal muscle of hypertensive subjects are rare. We therefore developed a new method for the determination of muscle blood flow noninvasively and quantitatively by a combination of computed tomography and venous occlusion plethysmography (strain-gauge method). At two sites on one forearm (p = site of the largest diameter, d = 1 cm proximal to the epicondyle lat.) the volumes of tissues [Vt = total volume, VM = muscle volume, VSk = bone volume, VR = residual volume = Vt - (VM + VSk)] were determined by computed tomograms and total forearm blood flow (Fp and Fd, respectively in ml/100 ml tissue x min) measured by strain-gauge plethysmography. After correcting for the bone volume at the different sites, Fp and Fd were transformed into the absolute influx rates of blood volume (Qp and Qd). From Qp and Qd and the different tissue volumes, the muscle blood flow (FM in ml/100 ml muscle x min) could be calculated: (formula; see text) Results thus derived were compared with data from the literature Cooper et al. (17). At rest there was neither a significant difference in Fp (own results: 3.62 +/- 1.67, Cooper: 3.25 +/- 1.42 ml/100 ml tissue x min, means +/- S.D.) nor in FM (4.08 +/- 2.07 and 3.66 +/- 1.57 ml/100 ml muscle x min, respectively), however, Fp and FM were significantly different (p less than 0.05). In the mean, FM was 13% greater than Fp, range: -40 to +38% (Cooper 15%, range: -17 to +43%). The individual difference could not be predicted by any of the parameters. Testing the procedure by means of a pharmacological agent (clonidine) with known effects on muscle blood flow (no change) and skin blood flow (decrease) revealed the correct reproduction of this hemodynamic pattern with our method. The usual identification of total with muscle blood flow would have led to false conclusions.

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“…Since the beginning of the century, a variety of methodologies have been evaluated to assess muscle and/or skin blood flow under in-vivo conditions; most of them have been a b a n d o n e d because of their invasiveness and/or because they were associated with the injection of radioactive of toxic substances [6][7][8]11].…”

mentioning

confidence: 99%

Skin microcirculation in healthy subjects and patients with arteriosclerosis

Wenzel

Bruck

Baumgart

et al. 1999

Herz

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The concept to use the human skin microcirculation as a pharmacological in-vivo test system is old; however, methods developed in the 50s have been abandoned because of side effects and/or use of radioactive substances. We describe a newly developed minimally invasive method that allows in-vivo pharmacology in the human skin microcirculation injecting very low doses of a substance of drug without any systemic effects. The double injection technique (DIT) bears the potential to predict the effects of a drug and/or the vascular reactivity or dysfunction of other less accessible areas of the circulation (e.g. the myocardium). The DIT has been applied for studies in healthy volunteers and patients with atherosclerosis; the focus of interest was endothelial (dys-)function and the effect of exogenous vasoactive drugs. Using endothelin antagonists, we investigated the role of endogenous endothelin under physiological conditions and in atherosclerosis. The NO-synthase inhibitor L-NMMA has been applied to study the L-arginine-NO-pathway and the role of endothelial adrenoceptors. Ongoing studies with the DIT comparing coronary and skin microcirculation may help to develop minimally invasive methods to predict the effects of drugs and vascular function in the heart.

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Fortlaufende Bestimmung der Hautdurchblutung am Menschen mit einem elektrischen W�rmeleitmesser

Cited by 116 publications

References 18 publications

Muscle and skin blood flow in the human forearm during insulin hypoglycaemia

Muscle and skin blood flow in the human forearm during insulin hypoglycaemia

Noninvasive, quantitative determination of muscle blood flow in man by a combination of venous-occlusion plethysmography and computed tomography

Skin microcirculation in healthy subjects and patients with arteriosclerosis

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