Fortschrittsbericht Die intestinale Phase der Peptidabsorption

Friedrich, M.

doi:10.1002/food.19820261014

Cited by 7 publications

(1 citation statement)

References 73 publications

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“…Proteinhydrolysates are characterized by a rapid intestinal absorption of amino acids (7) resulting in elevated plasma concentrations of amino acids postprandially (20). We have shown that elevated amino acids concentrations in serum can aggravate the physiologie cholestasis of newborns in VLBW-infants (18).…”

Section: Introductionmentioning

confidence: 99%

Protein Supplementation of Human Milk for the Nutrition of VLBW-Infants: Human milk protein vs. meat protein hydrolysate

Boehm

Senger²,

Friedrich³

et al. 1990

Klin Padiatr

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In 25 very low birth weight infants appropriate for gestational age the influences of different human milk (HM) preparations on weight gain, gross indices of nitrogen metabolism and energy balance were studied during the second month of postnatal life. HM was fortified either by HM-protein (HMP) or by an enzymatic meat protein hydrolysate (PH) to protein concentrations between 1.5 and 1.7 g/100 ml. The caloric densities of both HM preparations were similar between 62 and 68 kcal/100 ml. There were no differences in weight gain (MM + HMP: 18.6 +/- 3.4 g/kg/day; HM + PH: 16.5 +/- 4.1 g/kg/day), nitrogen retention (HM + HMP: 31.5 +/- 3.1 mmol/kg/day; HM + PH: 30.0 +/- 3.2 mmol/kg/day), and the preprandial estimated essential amino acid profiles between the both feeding groups. In contrast the serum concentrations of alpha-amino-nitrogen 60 minutes postprandially were elevated in the infants fed HM + PH in comparison to the infants fed HM + HMP. This high postprandial amino acid concentrations in serum in the group fed HM + PH were accompanied by increased bile acids concentrations in serum, higher renal amino acid excretion and increased fecal fat losses. The results suggest that due to the more rapid intestinal absorption of amino acids from PH than from HMP the concentrations of amino acids increase postprandially which results in a detectable increase of the newborn cholestasis in these infants. Nevertheless, the scale of these metabolic responses to feeding protein hydrolysates is small and without detectable influences on nitrogen retention or weight gain.

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Section: Introductionmentioning

confidence: 99%

Protein Supplementation of Human Milk for the Nutrition of VLBW-Infants: Human milk protein vs. meat protein hydrolysate

Boehm

Senger²,

Friedrich³

et al. 1990

Klin Padiatr

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Bedeutung von Peptiden enzymatisch abgebauter Proteine als Bestandteile von Nahrungsmitteln

Behnké

1985

Nahrung

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In comparison with proteins, peptides occur only in very small amounts in foods. An exception are peptides, which result from proteins to a higher or lower extent in the course of natural or microbial disintegration or ripening processes. Recently, proteinases are used for process optimization or quality improvement in the production or processing of foods. Usually, the protein degradation in these cases is only small, but functional properties may be improved. Peptides frequently show a bitter taste and may limit the sensory value of foods. Sources and possibilities to remove the bitter taste are discussed. In dietetics protein-free peptide diets are introduced for special indications. They contain oligopeptides which are produced by intensive hydrolysis of proteins. The intestinal absorption of small peptides is different from that of free amino acids. Finally, physiological effects of some dietary peptides are discussed (e.g. peptides as enzyme inhibitors, coeliac disease as a gliadine-peptide induced enteropathy, exorphines as neurotransmitters).

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Oral cyclacillin interacts with the absorption of oral ampicillin, amoxycillin, and bacampicillin

Sjövall¹,

Alván

Westerlund

1985

Eur J Clin Pharmacol

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The relative bioavailabilities of single oral doses of ampicillin, amoxycillin, and bacampicillin were compared with and without concomitant administration of a six-times higher molar dose of cyclacillin. As the absorption of cyclacillin has been shown to involve a capacity-limited transport system in animals, it was selected as the reference compound for the study. The treatments were given to 14 fasting volunteers using a randomized, complete crossover design. The drugs in plasma and urine were determined by liquid chromatography. Renal clearance was 17%, 10% and 19% lower when ampicillin, amoxycillin, and bacampicillin were given together with cyclacillin. Consequently, differences in the relative bioavailability were based on urinary recoveries assuming constant non-renal clearance. When amoxycillin was given with cyclacillin there was a 67% delay in the time of the plasma peak concentration, and an 8% lower urinary recovery than when it was given alone. There was a 50% and 33% delay in the tmax of ampicillin and bacampicillin when combined with cyclacillin; the urinary recovery of ampicillin in the combination was 10% lower but that of bacampicillin was similar. There was also a 20% delay in the tmax of cyclacillin when combined with amoxycillin. The differences in renal clearance indicate an interaction in the renal elimination of the drugs, but the effect was probably not the explanation for the marked shift in time of the absorption of these rapidly absorbed drugs. The results support the existence of a capacity-limited transport system for aminopenicillins in the human gut.

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Fortschrittsbericht Die intestinale Phase der Peptidabsorption

Cited by 7 publications

References 73 publications

Protein Supplementation of Human Milk for the Nutrition of VLBW-Infants: Human milk protein vs. meat protein hydrolysate

Protein Supplementation of Human Milk for the Nutrition of VLBW-Infants: Human milk protein vs. meat protein hydrolysate

Bedeutung von Peptiden enzymatisch abgebauter Proteine als Bestandteile von Nahrungsmitteln

Oral cyclacillin interacts with the absorption of oral ampicillin, amoxycillin, and bacampicillin

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