Fos-Expressing Neuronal Ensembles in Addiction Research

Hope, Bruce T.

doi:10.1016/b978-0-12-812202-0.00006-3

Cited by 1 publication

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“…Egr2 is, furthermore, the gene most robustly induced by cocaine in the dorsal striatum [(Gonzales et al, 2020; Mukherjee et al, 2018); Supplementary file 4], and is a sensitive indicator of cocaine-engaged striatal cell assemblies (Gonzales et al, 2020). Transgenic approaches based on IEG expression support genetic access to neuronal assemblies recruited by experience (Cruz et al, 2013; DeNardo and Luo, 2017; Hope, 2019; Minatohara et al, 2016; Sakaguchi and Hayashi, 2012; Tonegawa et al, 2015). To address the potential role of dorsal striatal assemblies expressing Egr2 in the development of behavioral sensitization to cocaine, we utilized transgenic Egr2-Cre knock-in mice, expressing Cre recombinase under the regulation of the Egr2 promoter (Voiculescu et al, 2000).…”

Section: Resultsmentioning

confidence: 99%

Egr2 induction in Drd1⁺ ensembles of the ventrolateral striatum supports the development of cocaine reward

Mukherjee

Ashwal-Fluss

et al. 2020

Preprint

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Drug addiction develops due to brain-wide plasticity within neuronal ensembles, mediated by dynamic gene expression. Though the most common approach to identify such ensembles relies on immediate early gene expression, little is known of how the activity of these genes is linked to modified behavior observed following repeated drug exposure. To address this gap, we present a broad-to-specific approach, beginning with a comprehensive investigation of brain-wide cocaine-driven gene expression, through the description of dynamic spatial patterns of gene induction in subregions of the striatum, and finally address functionality of region-specific gene induction in the development of cocaine preference. Our findings reveal differential cell-type specific dynamic transcriptional recruitment patterns within two subdomains of the dorsal striatum following repeated cocaine exposure. Furthermore, we demonstrate that induction of the IEG Egr2 in the ventrolateral striatum, as well as the cells within which it is expressed, are required for the development of cocaine seeking.Impact statementVLS ensembles are dynamically recruited by cocaine experiences to mediate cocaine reward.

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Section: Resultsmentioning

confidence: 99%

Egr2 induction in Drd1⁺ ensembles of the ventrolateral striatum supports the development of cocaine reward

Mukherjee

Ashwal-Fluss

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

Fos-Expressing Neuronal Ensembles in Addiction Research

Cited by 1 publication

References 120 publications

Egr2 induction in Drd1⁺ ensembles of the ventrolateral striatum supports the development of cocaine reward

Egr2 induction in Drd1⁺ ensembles of the ventrolateral striatum supports the development of cocaine reward

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Fos-Expressing Neuronal Ensembles in Addiction Research

Cited by 1 publication

References 120 publications

Egr2 induction in Drd1+ ensembles of the ventrolateral striatum supports the development of cocaine reward

Egr2 induction in Drd1+ ensembles of the ventrolateral striatum supports the development of cocaine reward

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Egr2 induction in Drd1⁺ ensembles of the ventrolateral striatum supports the development of cocaine reward

Egr2 induction in Drd1⁺ ensembles of the ventrolateral striatum supports the development of cocaine reward