Fosamax in treatment of postmenopausal osteoporosis and its complications

Povoroznyuk, Vladyslav; Nikonenko, Pavel I.; Grygoryeva, N.V.

doi:10.1016/j.bone.2007.12.156

Cited by 1 publication

(2 citation statements)

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“…Despite the lack of a clearly defined pharmacological mechanism of action, previous studies have demonstrated that ICA, extracted from the dried leaves of the medicinal plant Herba Epimedii , stimulates osteogenic differentiation in vitro and prevents bone loss in vivo (26–31). Because of its low toxicity and favorable side effect profile, ICA would be an attractive and promising candidate for the treatment and prevention of OP (30).…”

Section: Discussionmentioning

confidence: 99%

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Icariin improves osteoporosis, inhibits the expression of PPARγ, C/EBPα, FABP4 mRNA, N1ICD and jagged1 proteins, and increases Notch2 mRNA in ovariectomized rats

Liu

Xiong

Zhu

et al. 2017

Experimental and Therapeutic Medicine

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Icariin (ICA) is a pharmacologically active flavonoid glycoside that shows promise in the treatment and prevention of osteoporosis (OP). However, the mechanisms underlying the anti-osteoporotic effects of ICA remain largely unclear. The present study used quantitative polymerase chain reaction, western blot and immunohistochemical analysis to examine the effects of ICA on several key targets in the Notch signaling pathway in bone tissue in ovariectomized rats. It was observed that ICA has a pronounced beneficial effect on OP rats and inhibits the expression of peroxisome proliferator-activated receptor γ (PPARγ), CCAAT/enhancer binding protein α (C/EBPα) and fatty acid-binding protein 4 (FABP4) mRNA. In addition, it was identified that ICA downregulates the expression of notch1 intracellular domain (N1ICD) and Jagged1 proteins in bone tissue, and suppresses the effect of N1ICD on Notch2 mRNA expression. It is proposed that ICA inhibits the differentiation of mesenchymal stem cells into adipocytes by inhibiting the expression of PPARγ, C/EBPα and FABP4 mRNA via the Notch signaling pathway. In addition, it is proposed that ICA inhibits the expression of Notch2 mRNA by suppressing the effect of N1ICD. In conclusion, the results provide further mechanistic evidence for the clinical efficacy of ICA in the treatment of OP.

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Section: Discussionmentioning

confidence: 99%

“…Fosamax was chosen as the positive control since it is known to increase bone mineral density (31). The present study shows that ICA effectively reduces bone mass loss in OVX rats, increases bone trabecular number and thickness, reduces the degree of separation of trabecular bone, and improves its morphological structure.…”

Section: Discussionmentioning

confidence: 99%