Fosfomycin concentrations in epithelial lining fluid in weaning piglets

Soraci, A. L.; Pérez, Denisa Soledad; Martínez, Guadalupe; Amanto, Fabián Andrés; Tapia, María Ofelia; Dieguez, Susana Nelly; Paggi, María Belén Fernández

doi:10.1111/j.1365-2885.2011.01344.x

Cited by 9 publications

(11 citation statements)

References 41 publications

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“…In addition, its high permeability even to abscesses and areas with a poor vascularization makes it a popular drug for treatment of infectious poultry diseases. Fosfomycin pharmacokinetics have been well studied in veterinary field [13][14][15]. For example, Soraci et al [13] showed that after intramuscular administration (15 mg/kg body weight) of disodium FOS, the drug reaches concentrations above the MIC90 of pathogens such as Streptococcus, for more than 8 h in bronchial epithelial lining fluid.…”

Section: Discussionmentioning

confidence: 99%

“…Fosfomycin pharmacokinetics have been well studied in veterinary field [13][14][15]. For example, Soraci et al [13] showed that after intramuscular administration (15 mg/kg body weight) of disodium FOS, the drug reaches concentrations above the MIC90 of pathogens such as Streptococcus, for more than 8 h in bronchial epithelial lining fluid. These results demonstrate that FOS is useful for treating diseases caused by extracellular microorganisms that are involved in swine respiratory disease [13].…”

Section: Discussionmentioning

confidence: 99%

“…For example, Soraci et al [13] showed that after intramuscular administration (15 mg/kg body weight) of disodium FOS, the drug reaches concentrations above the MIC90 of pathogens such as Streptococcus, for more than 8 h in bronchial epithelial lining fluid. These results demonstrate that FOS is useful for treating diseases caused by extracellular microorganisms that are involved in swine respiratory disease [13]. Despite all these advantages of fosbac, to the authors' knowledge, possible adverse effects of fosbac remain unclear in birds.…”

Section: Discussionmentioning

confidence: 99%

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The effect of fosbac on liver and kidney function parameters in broilers

Motaghi¹,

Laji²,

Sepehri³

et al. 2017

JCLM

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The effect of fosbac on liver and kidney function parameters in broilers

Motaghi¹,

Laji²,

Sepehri³

et al. 2017

JCLM

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“…The FOS concentrations were measured using a High Performance Liquid Chromatography-Mass-Mass Spectrometry (HPLC-MS'MS) according to the method determined by Soraci et al (2012). The HPLC-MS/MS (Thermo Electron Corporation) system consisted of a Finnigan Surveyor autosampler and a quaternary pump Finnigan MS.…”

Section: Methodsmentioning

confidence: 99%

“…Furthermore, determined FOS penetration in HEP-2 cell cultures and their interactive effect with DON and they concluded that the presence of the mycotoxin does not alter the intracellular distribution of the antibiotic. On the other hand, Soraci et al (2012) The FOS showed clinical efficacy in the treatment of pulmonary diseases. Nevertheless, concentrations in Alveolar Macrophages (AM) (biophase for facultative and obligate intracellular microorganisms) have not been established in any species yet.…”

Section: Introductionmentioning

confidence: 99%

Intracellular Concentrations of Fosfomycin in Alveolar Macrophages from Weaning Piglets

Pérez¹,

Soraci²,

Martínez³

et al. 2015

Research J. of Veterinary Sciences

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At weaning, piglets are more susceptible to infectious diseases, being respiratory syndromes one of the most frequent conditions. Fosfomycin is indicated for the treatment of a variety of porcine bacterial pathogens, with MIC 90 ranging between 0.25-0.50 µg mLG 1 . Fosfomycin exhibits a time-dependent killing. Thus, killing of bacteria occurs when its concentrations remain constantly above the MIC. Fosfomycin concentrations in respiratory cells and epithelial lining fluid of pigs have already been studied. Although, fosfomycin showed clinical efficacy in the treatment of pulmonary diseases, concentrations in alveolar macrophages (biophase for facultative and obligate intracellular microorganisms) have not been established in any species. The present study determined the intracellular concentrations of disodium fosfomycin in alveolar macrophages after a single IM dose of 15 mg kgG 1 in the gluteal muscle. Concentrations ranged from 0.14-1.52 µg mLG 1 , being lower than those found in epithelial lining fluid (49.03%) and respiratory cells (54.48%). The C max was 1.52 µg mLG 1 and T max was 4 h. Concentrations exceeded the MIC 90 for most pathogens of importance in pig production for up to six hours (T>MIC = 6 h). Therefore, fosfomycin may be useful in the treatment of lung infections caused by facultative intracellular microorganisms.

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Penetration of Antibacterial Agents into Pulmonary Epithelial Lining Fluid: An Update

Drwiega

Rodvold

2021

Clin Pharmacokinet

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A comprehensive review of drug penetration into pulmonary epithelial lining fluid (ELF) was previously published in 2011. Since then, an extensive number of studies comparing plasma and ELF concentrations of antibacterial agents have been published and are summarized in this review. The majority of the studies included in this review determined ELF concentrations of antibacterial agents using bronchoscopy and bronchoalveolar lavage, and this review focuses on intrapulmonary penetration ratios determined with area under the concentration-time curve from healthy human adult studies or pharmacokinetic modeling of various antibacterial agents. If available, pharmacokinetic/pharmacodynamic parameters determined from preclinical murine infection models that evaluated ELF concentrations are also provided. There are also a limited number of recently published investigations of intrapulmonary penetration in critically ill patients with lower respiratory tract infections, where greater variability in ELF concentrations may exist. The significance of these changes may impact the intrapulmonary penetration in the setting of infection, and further studies relating ELF concentrations to clinical response are needed. Phase I drug development programs now include assessment of initial pharmacodynamic target values for pertinent organisms in animal models, followed by evaluation of antibacterial penetration into the human lung to assist in dosage selection for clinical trials in infected patients. The recent focus has been on β-lactam agents, including those in combination with β-lactamase inhibitors, particularly due to the rise of multidrug-resistant infections. This manifests as a large portion of the review focusing on cephalosporins and carbapenems, with or without β-lactamase inhibitors, in both healthy adult subjects and critically ill patients with lower respiratory tract infections. Further studies are warranted in critically ill patients with lower respiratory tract infections to evaluate the relationship between intrapulmonary penetration and clinical and microbiological outcomes. Our clinical research experience with these studies, along with this literature review, has allowed us to outline key steps in developing and evaluating dosage regimens to treat extracellular bacteria in lower respiratory tract infections.

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Fosfomycin concentrations in epithelial lining fluid in weaning piglets

Cited by 9 publications

References 41 publications

The effect of fosbac on liver and kidney function parameters in broilers

The effect of fosbac on liver and kidney function parameters in broilers

Intracellular Concentrations of Fosfomycin in Alveolar Macrophages from Weaning Piglets

Penetration of Antibacterial Agents into Pulmonary Epithelial Lining Fluid: An Update

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