Fosfomycin for the Treatment of Prostate Infection

Abstract

A 69-year-old man with diabetes mellitus was diagnosed with a prostate abscess. Although the pathogen was fluoroquinolone-resistant Escherichia coli and the oral administration of trimethoprim-sulfamethoxazole was initiated, the infection recurred after three months. The antibiotic therapy was subsequently changed to intravenous fosfomycin, and the patient's condition promptly improved. Four weeks of fosfomycin therapy was successfully continued without any adverse events. In the era of antibiotic resistance, revival of forgotten drugs is an important issue for clinicians. Fosfomycin can be applied as an alternative option for prostate infections, considering the remaining susceptibility of multidrug-resistant pathogens to fosfomycin and the good pharmacokinetics of this drug in prostatic tissue.

Effective Treatment for Uncomplicated Urinary Tract Infections with Oral Fosfomycin, Single Center Four Year Retrospective Study

“…Fosfomycin therapy in the complicated UTIs was, according to our data, ineffective in 51.3% of cases (i.e., the drug has no effect, or there is early relapse of symptoms within two months). In the treatment of complicated UTIs or UTIs caused by multidrug-resistant microbes, many studies suggested multiple dose regimens of fosfomycin [ 1 , 21 , 22 , 23 , 24 , 25 , 26 ] with three-dose regimens being the most common. Patients in our cohorts were mostly treated with a single-dose regimen; however, about one-third of them received multiple doses.…”

Pharmacodynamic and pharmacokinetic studies and prostatic tissue distribution of fosfomycin tromethamine in bacterial prostatitis or normal rats

“…Bacterial prostatitis is a disease that accounts for a quarter of all visits of men to urology clinics. Treating prostate infections is challenging due to the low penetration of antibiotics into prostatic tissues (Hagiya et al., ). The use of fluoroquinolones is recommended in cases of BP.…”