Fossil record of meningioma

Czarnetzki, Alfred; Schwaderer, Erwin; Pusch, Carsten M.

doi:10.1016/s0140-6736(03)14044-5

Cited by 22 publications

(10 citation statements)

References 3 publications

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“…Cancers as well as benign neoplasias are very old diseases, which have afflicted animals since long before man appeared on earth [1,2] and human beings since prehistoric times [1,3]. Written records concerning cancer can be traced to ancient Egypt [4].…”

Section: Introductionmentioning

confidence: 99%

The biological sense of cancer: a hypothesis

Ruggiero

Bustuoabad

2006

Theor Biol Med Model

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Background: Most theories about cancer proposed during the last century share a common denominator: cancer is believed to be a biological nonsense for the organism in which it originates, since cancer cells are believed to be ones evading the rules that control normal cell proliferation and differentiation. In this essay, we have challenged this interpretation on the basis that, throughout the animal kingdom, cancer seems to arise only in injured organs and tissues that display lost or diminished regenerative ability.

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Section: Introductionmentioning

confidence: 99%

The biological sense of cancer: a hypothesis

Ruggiero

Bustuoabad

2006

Theor Biol Med Model

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“…This characteristic was also noticed in previous investigations of the skull, and can be caused by a benign tumour (meningioma) [1] , [2] . Although the discovery of soft-tissue cancer is rare in archaeological samples, a case of meningioma has been diagnosed in a 365 000 years old skull from Steinheim/Murr, Germany [3] .…”

Section: Resultsmentioning

confidence: 99%

Analysis of the Putative Remains of a European Patron Saint–St. Birgitta

et al. 2010

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Saint Birgitta (Saint Bridget of Sweden) lived between 1303 and 1373 and was designated one of Europe's six patron saints by the Pope in 1999. According to legend, the skulls of St. Birgitta and her daughter Katarina are maintained in a relic shrine in Vadstena abbey, mid Sweden. The origin of the two skulls was assessed first by analysis of mitochondrial DNA (mtDNA) to confirm a maternal relationship. The results of this analysis displayed several differences between the two individuals, thus supporting an interpretation of the two skulls not being individuals that are maternally related. Because the efficiency of PCR amplification and quantity of DNA suggested a different amount of degradation and possibly a very different age for each of the skulls, an orthogonal procedure, radiocarbon dating, was performed. The radiocarbon dating results suggest an age difference of at least 200 years and neither of the dating results coincides with the period St. Birgitta or her daughter Katarina lived. The relic, thought to originate from St. Birgitta, has an age corresponding to the 13th century (1215–1270 cal AD, 2σ confidence), which is older than expected. Thus, the two different analyses are consistent in questioning the authenticity of either of the human skulls maintained in the Vadstena relic shrine being that of St. Birgitta. Of course there are limitations when interpreting the data of any ancient biological materials and these must be considered for a final decision on the authenticity of the remains.

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“…Although Plater is still considered the first person reporting a meningioma in the history of medicine, in fact this is not the first one registered in humans. This finding is based on the paleonthological studies performed on human fossils discovered in 1933, in a quarry near Steinheim an der Murr, in southern Germany, in which lesions compatible with meningioma had been found, dating for about Arch Clin Cases 2018; 5(1): [20][21][22][23][24][25][26][27][28][29][30] 365,000 years old [28,31]. Accordingly, this is the first case of benign leptomeningeal lesion resembling meningioma reported in Homo erectus line [28,31].…”

Section: Historical Perspective and Morphology Fundamentalsmentioning

confidence: 91%

Meningiomas – insights into genetics and correlations with histological features

Grigoraș¹,

Rîșcanu²,

Amălinei³

2018

Arch Clin Cases

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Meningiomas are the most common intracranial tumors. They occur more frequently in women and may be completely asymptomatic. According to the World Health Organization, the ability to invade and to develop recurrences represents the criterion which is used to designate three grades of meningiomas. In the last decade, advanced knowledges in genetics and molecular biology have improved our understanding of the clinical behavior of meningiomas. In addition to mutation or loss of NF2 gene, recurrent mutations of other genes, such as TERT,

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Fossil record of meningioma

Cited by 22 publications

References 3 publications

The biological sense of cancer: a hypothesis

The biological sense of cancer: a hypothesis

Analysis of the Putative Remains of a European Patron Saint–St. Birgitta

Meningiomas – insights into genetics and correlations with histological features

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