2023
DOI: 10.1101/2023.09.04.556143
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Four chromosomally clustered class-C β-lactamases (blaAmpH1/2/3/4) control the cephalosporin hydrolysis inMycobacterium tuberculosisand similar genetic loci appeared as pseudogenes inMycobacterium leprae

Asit Kumar Chakraborty

Abstract: Mycobacterium tuberculosis (Mt) chromosomal ten PBPs and one class-A beta-lactamase (blaC) were implicated in multi-drug resistance against penicillin, cephalosporin and carbapenem drugs. The E. coli Class-A PBP1A and PBP1B proteins referred as PonA1 and PonA2 in Mt with 34 percent homologies whereas Class-B PBP2 referred as PbpA and PbpB sub-class proteins with 27 percent homologies. The class-C PBPs were, PBP4, MecA_N, DacB1, DacB2 and AmpH1-AmpH4. During database search, we found that many Mt Pbp4 had no ho… Show more

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