Four cytotoxic annonaceous acetogenins from the seeds of <i>Annona squamosa</i>

Miao, Yunjie; Xu, Xiaofang; Yuan, Fangyan; Shi, Yue; Chen, Y; Chen, J; Li, X

doi:10.1080/14786419.2015.1055490

Cited by 36 publications

(9 citation statements)

References 22 publications

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“…is a promising source of potential compounds exhibiting cytotoxic activities toward many human cancer cells in vitro, as reviewed by Formagio et al (2015). Four new Annonaceous acetogenins, such as squamocin-I, -II and -III, and squamoxinone-D, were isolated from the seeds of Annona squamosa and were found to inhibit proliferation of Hep G2, SMMC 7721, BEL 7402, BGC 803 and H460 human cancer cell lines (Chen et al, 2012;Miao et al, 2015). Moreover, the constituents (flavonoids, isoquinoline alkaloids and Annonaceous acetogenins) of Annona muricata leaf extract were shown to inhibit prostate cancer proliferation, viability and clonogenic capacity in vitro (Yang et al, 2015).…”

Section: Resultsmentioning

confidence: 99%

Cytotoxic and genotoxic effects of extracts fromAnnona montanaM. fruit

Bailón-Moscoso

Romero-Benavides

Orellana

et al. 2016

Food and Agricultural Immunology

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Pulverized immature fruits of Annona montana M. are commonly used for biomedical applications, especially in the treatment of dysentery. The aim of this study was to investigate whether hexane, ethyl acetate or methanol extracts of A. montana M. can be cytotoxic to human tumor cells or exhibit genotoxic effects on normal human cells. The organic extracts were shown to inhibit survival of tumor cells originating from human astrocytoma, breast, colon, lung and prostate cancers. Furthermore, they were found to induce DNA damage in normal human lymphocytes, as shown by comet assay. The genotoxic effects observed suggest that traditional folk medicines prepared from extracts of the immature fruit of A. montana should be used with caution.

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Section: Resultsmentioning

confidence: 99%

Cytotoxic and genotoxic effects of extracts fromAnnona montanaM. fruit

Bailón-Moscoso

Romero-Benavides

Orellana

et al. 2016

Food and Agricultural Immunology

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“…The seed oil as well as the essential oils from the pericarp, the leaves, and the stembark of A. squamosa displayed anticancer activity against a broad range of human cancer cell lines [47][48][49][50][51][52][53][54][55][56][57][58][59][60][61][62] as well as H22 hepatoma implanted into laboratory mice [51,[60][61][62][63]. The anticancer effects have particularly been attributed to annonaceous acetogenins in the seed oil [47][48][49][50][51][52][53]59] as well as annonaceous acetogenins, terpenes, and terpenoids, and alkaloids in pericarp, leaves, and stembark [56][57][58][60][61][62]. Interestingly, the acetogenin squamoxinone-D displayed selective cytotoxicity against the (drug-resistant) SMMC 7721/T cell line [59], and annonaceous acetogens were highly active in H22 hepatoma-bearing laboratory mice [64].…”

Section: Annonaceae-annona Squamosa Lmentioning

confidence: 99%

Anticancer Activity of Uncommon Medicinal Plants from the Republic of Suriname: Traditional Claims, Preclinical Findings, and Potential Clinical Applicability against Cancer

Mans¹,

Irving²

2019

Pharmacognosy - Medicinal Plants

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Despite much progress in our understanding of the essence of cancer, remarkable advances in methods for early diagnosis, the expanding array of antineoplastic drugs and treatment modalities, as well as important refinements in their use, this disease is among the leading causes of morbidity and mortality in many parts of the world. In fact, the next decade is anticipated to bring over 20 million new cases per year globally, about half of whom will die from their disease. This indicates a need for better strategies to deal with cancer. One way to go forward is to draw lessons from ancient ethnopharmacological wisdom and to evaluate the plant biodiversity for compounds with potential antineoplastic activity. This approach has already yielded many breakthrough cytotoxic drugs such as vincristine, etoposide, paclitaxel, and irinotecan. The Republic of Suriname (South America), renowned for its pristine and highly biodiverse rain forests as well as its ethnic, cultural, and ethnopharmacological diversity, could also contribute to these developments. This chapter addresses the cancer problem throughout the world and in Suriname, extensively deals with nine plants used for treating cancer in the country, and concludes with their prospects in anticancer drug discovery and development programs.

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“…Compound 294 was cytotoxic toward SNU387 cell line with an IC 50 value of 0.71 μM (Zhang et al, 2016j ). The seeds of Annona squamosa (Guangdong, China) afforded four new annonaceous acetogenins (ACGs), squamocins I–III ( 295 - 297 ), and squamoxinone D. Compound 297 were most active against H460 cell line with an IC 50 value of 0.0492 μg/mL (Miao et al, 2016 ). Four new taxane derivatives were obtained from the whole plants of Taxus wallichiana .…”

Section: Terrestrial Plantsmentioning

confidence: 99%