Four-day randomized controlled crossover trial evaluating the antiplaque effect of a combination of green tea and Salvadora persica L. mouthwash

Salah, Rasha; Abdulbaqi, Hayder Raad; Mohammed, Ayser Najah; Abdulkareem, Ali A.

doi:10.1016/j.hermed.2020.100357

Cited by 4 publications

(1 citation statement)

References 23 publications

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“…gingivalis points to the possibility of using them as therapeutic agents to treat periodontal disorders [29], [30]. It is crucial to keep in mind that these results are preliminary and more research is required to completely comprehend the mechanisms of action of these plant extracts and to confirm their efficiency in vivo [4].…”

Section: Discussionmentioning

confidence: 99%

Synergistic Antimicrobial and Antibiofilm Activity of Panax Ginseng, Symphytum Officinale, and Metronidazole against P. gingivalis

Ibrahim,

Al-Mizraqchi,

Haider

2023

Preprint

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Background: The biofilm-forming bacteria Porphyromonas gingivalis (P. gingivalis) is primarily responsible for periodontal disorders, which continue to be a global health issue. Despite the widespread use of antibiotics like metronidazole, other potent therapeutic a crucial quorum sensing molecule implicated in the formation of P. gingivalis biofilm. Approaches are now being explored due to the growing challenge of antibiotic resistance. Objective: In particular, chemicals from Symphytum Officinale (S) and Panax Ginseng (G) plants will be examined in this study to assess if they have the ability to inhibit biofilm and to prevent the development of acylated homoserine lactones (AHLs), a quorum sensing molecule. Materials and Methods: With Metronidazole serving as a control, the antibacterial effects of these substances (Symphytum Officinale and Panax Ginseng) were examined against a standard strain and a clinical isolate of P. gingivalis. Dilutions of these plant extracts were used either alone (G+S) or in conjunction with metronidazole (G+S+F), to assess their antibacterial activity using antibacterial susceptibility test (inhibition zone), biofilm inhibition and disruption assay (optical density) and quorum sensing inhibition assay (AHL). Results: The combinations of Symphytum officinale, Panax Ginseng and metronidazole (S+G+F) showed the maximum effectiveness with highest zone of inhibition (25.000±0.001 mm) and biofilm inhibition (98.46%), and were comparable to G+S (inhibition zone of 24.341±0.593 mm and biofilm inhibition of 97.76%), and significantly different in the degree of biofilm inhibition with different treatment scenarios. Additionally, the plant's extracts and combinations are specific concentrations had a significant effect on the suppression of the generation of AHL (p &lt; 0.05). Conclusion: According to preliminary research, these plant-derived substances, especially when paired with metronidazole, significantly inhibited the growth of P. gingivalis biofilm providing valuable information for the development of innovative therapeutic approaches for periodontitis and other biofilm-associated illnesses.

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Section: Discussionmentioning

confidence: 99%

Synergistic Antimicrobial and Antibiofilm Activity of Panax Ginseng, Symphytum Officinale, and Metronidazole against P. gingivalis

Ibrahim,

Al-Mizraqchi,

Haider

2023

Preprint

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Formulation of Mouthwash Using Combined Herbal Extracts to Control the Predominant Oral Pathogens and Biofilm

Sakthivel,

Sankaran,

Rengasamy

et al. 2024

Journal of Herbal Medicine

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Short-Term (4 Day) Effects of Oral Rinsing with Miswak and Green Tea on Gingival Crevicular Fluid Flow and IL-1β Levels: A Pilot Study

Salah

Abdulbaqi

2023

Healthcare

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Despite the antiplaque effect of mouth-rinsing with a combination composed of miswak (Salvadora persica L.) and green tea (Camellia sinensis var. assamica) extracts, no data are available regarding its effect on gingival tissue at the molecular level. This pilot study aimed to assess the effect of oral rinsing with this combination on gingival crevicular fluid (GCF) flow and IL-1β levels. Ten subjects rinsed with either the combination, 0.12% chlorhexidine gluconate (CHX) or distilled water without toothbrushing for 4 days after receiving baseline polishing. GCF IL-1β concentration, influx, resting volume and plaque quantity were measured at baseline and after 4 days for each intervention. No significant differences in GCF flow or resting volume were detected after rinsing with the different mouthwashes. A significant increase in GCF IL-1β concentration was evident only after rinsing with distilled water. Rinsing with combination induced a significant reduction in GCF influx (−0.086 ± 0.222) compared to CHX (0.088 ± 0.247) and distilled water (0.075 ± 0.201). Less plaque was detected after rinsing with combination and CHX. Short-term oral rinsing with this combination could potentially induce no significant changes in GCF flow and IL-1β concentration, and might retard inflammation. Thus, it might be considered in the production of natural oral healthcare products.

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Four-day randomized controlled crossover trial evaluating the antiplaque effect of a combination of green tea and Salvadora persica L. mouthwash

Cited by 4 publications

References 23 publications

Synergistic Antimicrobial and Antibiofilm Activity of Panax Ginseng, Symphytum Officinale, and Metronidazole against P. gingivalis

Synergistic Antimicrobial and Antibiofilm Activity of Panax Ginseng, Symphytum Officinale, and Metronidazole against P. gingivalis

Formulation of Mouthwash Using Combined Herbal Extracts to Control the Predominant Oral Pathogens and Biofilm

Short-Term (4 Day) Effects of Oral Rinsing with Miswak and Green Tea on Gingival Crevicular Fluid Flow and IL-1β Levels: A Pilot Study

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