Four-Dimensional XStrain Echocardiography: Correlation of Aortic Stiffness with Left Ventricular Diastolic, Systolic, and Strain Parameters in Healthy Adults – A Single-center Indian Perspective

Abstract

Background: Interrelationship of arterial stiffness with diastolic impairments of left ventricle (LV) in healthy population has been reported in several studies; however, to the best of our knowledge, no study till date has evaluated the relationship of aortic stiffness, with LV diastolic, systolic, and strain components, in healthy adults, by conventional, tissue Doppler imaging, and speckle-tracking echocardiography. Materials and Methods: Fifty-eight healthy participants were recruited (38 males and 20 females), and their mean age was 30.53 ± 12.22 years and 35.25 ± 10.61 years, respectively. A detailed assessment of aortic stiffness and elasticity, LV systolic, diastolic, and strain parameters was performed by the ingenious technology of four-dimensional XStrain echocardiography. Moreover, Pearson’s correlation coefficient was employed to investigate the association of aortic stiffness with LV diastolic, systolic, and strain functions. Results: A significant relationship was documented between aortic stiffness and a number of parameters of LV diastolic and systolic functions. On the contrary, there was an insignificant trend of positive or negative correlation of aortic stiffness with LV strain. Conclusion: This is the first study to document the correlation between aortic stiffness and various LV functions in healthy adults.

Four-Dimensional XStrain Echocardiographic Assessment of Left Ventricular Strain and Rotational Mechanics: Technology, Clinical Applications, Advantages and Limitations

“…In the academic literature, we encountered multiple studies using XStrain 4D STE in multiple clinical disease states, including congenital heart disease, coronary artery disease, hypertrophic cardiomyopathy, dilated cardiomyopathy, amyloidosis, psoriasis, acute myocarditis and progressive systemic sclerosis. Notably, a substantial number of research studies have been published in healthy adult populations [12,[16][17][18][19][20][21][22], with the aim of determining the normative value ranges of several strain, rotation and twist parameters.…”