Four-Factor Prothrombin Complex Concentrate for Patients With Trauma

Abstract

RETIC trial, 5 patients with trauma who had coagulopathy benefited more from fibrinogen supplementation than fresh frozen plasma administration. Only 16% of fibrinogen-treated patients received administration of 4F-PCC for reversal of trauma-induced coagulopathy, limiting the role of 4F-PCC in these patients who were treated appropriately with fibrinogen concentrate supplementation.