Four flavonoids from Echinosophora koreensis and their effects on alcohol metabolizing enzymes

Choi, Eun Ju; Kwon, Hak Cheol; Sohn, Young Chang; Nam, Chun Woo; Park, Hyun Bong; Kim, Cheol Young; Yang, Hyun Ok

doi:10.1007/s12272-009-1606-2

Cited by 19 publications

(12 citation statements)

References 15 publications

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“…Of the four flavonoids, sophoronol, the most effective, enhanced activities of ADH and ALDH by ninefold. Furthermore, four flavonoids promote the activity of ALDH in a dose‐dependent manner in vitro (Choi et al, ).…”

Section: Natural Compounds Beneficial For Ald Treatmentmentioning

confidence: 99%

Natural compounds in the chemoprevention of alcoholic liver disease

Zhu

Wang

et al. 2019

Phytotherapy Research

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Alcoholic liver disease (ALD), caused by excessive consumption of alcohol, is a major cause of chronic liver disease worldwide. Much effort has been expended to explore the pathogenesis of ALD. Hepatic cell injury, oxidative stress, inflammation, regeneration, and bacterial translocation are all involved in the pathogenesis of ALD. Immediate abstinence is the most important therapeutic treatment for affected individuals. However, the medical treatment for ALD had not advanced in a long period. Intriguingly, an increasing body of research indicates the potential of natural compounds in the targeted therapy of ALD. A plethora of dietary natural products such as flavonoids, resveratrol, saponins, and β‐carotene are found to exert protective effects on ALD. This occurs through various mechanisms composed of antioxidative, anti‐inflammatory, iron chelation, pro‐apoptosis, and/or antiproliferation of hepatic stellate cells and hepatocellular carcinoma cells. In this review, we will summarize current knowledge about the pathogenesis and treatments of ALD and focus on the potential of natural compounds in ALD therapies and underlying mechanisms.

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Section: Natural Compounds Beneficial For Ald Treatmentmentioning

confidence: 99%

Natural compounds in the chemoprevention of alcoholic liver disease

Zhu

Wang

et al. 2019

Phytotherapy Research

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“…Sophora koreensis (SK), from the Fabaceae family, is a perennial herb in the mountainous area of the Korean Peninsula [ 13 ]. The root and flower of SK species contain a large quantity of flavonoids [ 14 ], isoflavonoids [ 15 ], and scopoletin [ 16 , 17 ] having anti-oxidative capacity [ 18 ]. Scopoletin is a kind of phenolic coumarin with promising anti-inflammatory effects [ 19 ] that can protect the body from microbial attack and environmental stress, including mechanical injury [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Scopoletin Supplementation and Stocking Density on Growth Performance, Antioxidant Activity, and Meat Quality of Korean Native Broiler Chickens

Kang

Hosseindoust

et al. 2021

Foods

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Stocking density stress is one of the most common management stressors in the poultry industry. The present study was designed to investigate the effect of dietary Sophora koreensis (SK; 0 and 20 mg/kg diet) and stocking density (SD; 14 and 16 chickens/m2) on the antioxidant status, meat quality, and growth performance of native Korean chickens. There was a lower concentration of malondialdehyde (MDA) and a higher concentration of catalase, superoxide dismutase (SOD), and total antioxidant capacity in the serum and leg muscle with the supplementation of SK. The concentration of MDA was increased and concentrations of SOD were decreased in the leg muscle of chickens in low SD treatments. The SK-supplemented treatments showed an increased 3-ethylbenzothiazoline-6-sulfonate-reducing activity of leg muscles. The higher water holding capacity of breast muscle and a lower cooking loss and pH were shown in the SK-supplemented treatments. The addition of dietary SK resulted in a greater body weight gain and greater spleen and bursa Fabricius weight, as well as lower feed intake and abdominal fat. The low SD and supplementation of SK increased the concentrations of cholesterol. The concentration of glucose was increased in the low SD treatment. Corticosterone level was decreased in the SK-supplemented and low SD treatments. In conclusion, SK supplementation reduced the oxidative stress and increased meat quality and antioxidant status of chickens apart from the SD stress.

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“…Additionally, evidence indicates that DHM may reduce BEC through activation of ethanol metabolizing enzymes [ 22 , 45 ]. Enhanced ethanol metabolism is a property common of many flavonoids related to non-specific activity shared by polyphenolic structures [ 46 , 47 ]. In contrast to this, inhibition of ethanol-induced GABA A R potentiation and acute anti-intoxicating properties are not common to polyphenolic flavonoids, and thus unique to DHM [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Identification of Dihydromyricetin and Metabolites in Serum and Brain Associated with Acute Anti-Ethanol Intoxicating Effects in Mice

Carry

Kshatriya

Silva

et al. 2021

IJMS

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Dihydromyricetin is a natural bioactive flavonoid with unique GABAA receptor activity with a putative mechanism of action to reduce the intoxication effects of ethanol. Although dihydromyricetin’s poor oral bioavailability limits clinical utility, the promise of this mechanism for the treatment of alcohol use disorder warrants further investigation into its specificity and druggable potential. These experiments investigated the bioavailability of dihydromyricetin in the brain and serum associated with acute anti-intoxicating effects in C57BL/6J mice. Dihydromyricetin (50 mg/kg IP) administered 0 or 15-min prior to ethanol (PO 5 g/kg) significantly reduced ethanol-induced loss of righting reflex. Total serum exposures (AUC0→24) of dihydromyricetin (PO 50 mg/kg) via oral (PO) administration were determined to be 2.5 µM × h (male) and 0.7 µM × h (female), while intraperitoneal (IP) administration led to 23.8-fold and 7.2- increases in AUC0→24 in male and female mice, respectively. Electrophysiology studies in α5β3γ2 GABAA receptors expressed in Xenopus oocytes suggest dihydromyricetin (10 µM) potentiates GABAergic activity (+43.2%), and the metabolite 4-O-methyl-dihydromyricetin (10 µM) negatively modulates GABAergic activity (−12.6%). Our results indicate that administration route and sex significantly impact DHM bioavailability in mice, which is limited by poor absorption and rapid clearance. This correlates with the observed short duration of DHM’s anti-intoxicating properties and highlights the need for further investigation into mechanism of DHM’s potential anti-intoxicating properties.

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Four flavonoids from Echinosophora koreensis and their effects on alcohol metabolizing enzymes

Cited by 19 publications

References 15 publications

Natural compounds in the chemoprevention of alcoholic liver disease

Natural compounds in the chemoprevention of alcoholic liver disease

Effects of Scopoletin Supplementation and Stocking Density on Growth Performance, Antioxidant Activity, and Meat Quality of Korean Native Broiler Chickens

Identification of Dihydromyricetin and Metabolites in Serum and Brain Associated with Acute Anti-Ethanol Intoxicating Effects in Mice

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