Four limonoids from the seeds extract of Sandoricum koetjape

Bumi, Miranti B.; Heliawaty, Leny; Hermawati, Elvira; Syah, Yana Maolana

doi:10.1007/s11418-019-01303-w

Cited by 8 publications

(6 citation statements)

References 18 publications

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“…7 Several researchers have proven the efficacy of the Sentul plant as a vaginal discharge medicine, namely reporting that the methanol extract of Sentul bark can inhibit the growth of Candida albican fungus by 39.65%. 8 In addition, the ethyl acetate extract of the leaves of the Sentul harp plant also has anti-bacterial activity. 9 The results of the phytochemical screening examination of Sentul fruit peel simplicia powder showed the presence of groups of alkaloid compounds, flavonoids, tannins, saponins, glycosides, anthraquinone glycosides and steroids.…”

Section: Resultsmentioning

confidence: 99%

Antibacterial activity of Sentul fruit peel extract (Sandoricum koetjape) against Streptococcus mutans and Staphylococcus aureus

et al. 2022

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Introduction: Infectious mouth diseases are caused by microorganisms such as Staphylococcus aureus and Streptococcus mutans. Sentul fruit peel extract contains several phytochemical compounds, flavonoid compounds, saponins and tannins are aromatic hydroxyl groups that act as antibacterial so that they can be used as a treatment for infections of the mouth. This study aimed to determine the inhibitory ability of Sentul fruit peel extract (Sandoricum koetjape) against Streptococcus mutans and Staphylococcus Aureus bacteria which can cause oral infections. Method: Sentul fruit peel simplicia was extracted by maceration method with ethanol for 24 hours. The maceration method was chosen in this study because it is a method that is easy to do and uses simple tools, which is enough to soak the sample in a solvent. A filtering process followed this and the filtrate was then evaporated with a vacuum rotary evaporator at a temperature of 45oC, so that a thick extract was produced. The maceration process was repeated 2 times. After the extraction process, then proceed with liquid-liquid fractionation using distilled water. The thick extract was put into a separating funnel and distilled water was added. Then it was shaken and the aquadest fraction was taken, followed by evaporation with a vacuum rotary evaporator at 45oC, so that the aqua fraction of the ethanol extract was produced. Result: The results showed that the Sentul fruit peel extract was able to inhibit the growth of S. mutans and S. aureus bacteria as seen from the formation of a clear zone. Based on the ANOVA test, the extract concentration treatment had a significant effect (p<0.005) on the diameter of the clear zone on S. mutans and S. aureus bacteria. Positive control (streptomycin) showed significant differences in Duncan's test, because it produced the greatest antibacterial activity against test bacteria compared to negative control and various extract concentrations. The diameter of the clear zone in the positive control against S. mutans and S. aureus bacteria were 17.63±0.28 mm and 17.62±1.04 mm, respectively. Sentul peel ethanol extract of aqua fraction at a concentration of 100% gave the highest inhibition zone compared to concentrations of 75%, 50%, and 25%, although it was still smaller than the diameter of the clear zone in the positive control. In bacteria S. mutans, the ethanol extract of Sentul peel aqua fraction at a concentration of 100% gave a clear zone diameter of 14.31±1.06 mm and in S. aureus bacteria it gave a clear zone diameter of 15.34±1.81 mm. Conclusion: Sentul fruit peel extract (Sandoricum koetjape) has the ability to inhibit Streptococcus mutans bacteria and Staphylococcus Aureus bacteria.

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Section: Resultsmentioning

confidence: 99%

Antibacterial activity of Sentul fruit peel extract (Sandoricum koetjape) against Streptococcus mutans and Staphylococcus aureus

et al. 2022

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“…In the structure of the ring-seco limonoids, in addition to the single ring, can be cracked; there are also cases where the two and even the three rings are cleaved at the same time, such as rings A,B-seco (B291-B402), 60,86,102,107,126,142,155,156,158,182,[192][193][194][195][196][197] rings B,D-seco (B403-B457), 56,85,90,97,135,188,190,[198][199][200][201][202][203][204][205][206][207][208][209][210] rings A,D-seco (B458-B481), 37,43,127,161,162,211,212 and rings A,B,D-seco (B482) 213 limonoids (Tables S1.8-S1.10 †). Different rotations of the C-9/C-10 single bonds of rings A,B-seco limonoids in steric crowding might cause broad or missing NMR signals, which can be solved by building new 1,n-oxygen bridges through biomimetic alkaline hydrolysis.…”

Section: Reviewmentioning

confidence: 99%

“…13 and S1.14 †). Trijugin-class limonoids (C670-C692) 126,203,205,295,[313][314][315] with 8,11-linkage were still mainly isolated from Heynea trijuga and Cipadessa cinerascens. Walrobsins A-R (C693-C710), a class of 3,19-linkage limonoids found in Walsura robusta, 316,317 was previously reported only in Turraea wakeeldii.…”

Section: Reviewmentioning

confidence: 99%

Research progress of meliaceous limonoids from 2011 to 2021

Luo

Sun

et al. 2022

Nat. Prod. Rep.

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“…Limonoids have been isolated from the seeds of S. koetjape , such as three andirobin‐type limonoids called koetjapins A‐C (2) and the trijugin‐type limonoid koetjapin D (3). Only this latter compound has revealed an antiproliferative activity in vitro, with a capacity to inhibit the growth of P388 leukemia cells (IC 50 = 16.8 μg/mL); koetjapins A‐C were found inactive (Bumi et al, 2019). Limonoids of Meliaceae plants are generally complex with a high degree of oxidation and rearrangement exhibited in the parent limonoid structure (Roy and Saraf, 2006).…”

Section: Anticancer Compoundsmentioning

confidence: 99%

The health benefits of santol fruits and bioactive products isolated from Sandoricum koetjape Merr.: A scoping review

Bailly¹

2022

Journal of Food Biochemistry

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The santol tree (Sandoricum koetjape Merr.) is largely distributed in Southeast Asia. It produces useful timber and edible fruits, consumed fresh, and transformed. It has a wide range of traditional medicinal uses for the treatment of inflammatory disorders and digestive troubles. Numerous bioactive natural products have been isolated from the roots, leaves, stems, and fruits of S. koetjape, including flavonoids, limonoids, and terpenoids. The seeds are considered toxic and contain insecticidal limonoids. The present review provides a survey of the natural products isolated from different parts of the plant and discusses their pharmacological properties. Information on S. koetjape was collected through databases and analyzed, leading to the identification of about 30 natural products of interest. Bioactive compounds include limonoids, such as sandoripins A-B, sanjecumins A-B, and sandrapins A-E, and flavonoids with antioxidant, antibacterial, and insecticidal properties such as sandoricin and sandoripin derivatives. The santol plant contains various anti-inflammatory triterpenes, such as sentulic acid and koetjapic acid (KA). KA is the main product found in santol and a few other plants. This tetracyclic triterpenoid is endowed with anti-inflammatory and anticancer properties, with marked antimetastatic and antiangiogenic effects. Its potential molecular targets are discussed, notably the kinase mammalian target of rapamycin (mTOR) and other proteins (cyclooxygenase 2, DNA polymeraseβ). The water-soluble derivative potassium koetjapate (KK) affords an orally bioavailable derivative, with superior antiangiogenic properties compared to KA. The health benefits associated with the consumption of santol fruits shall be further considered, and the design of hemi-synthetic analogs of KA encouraged. Practical applicationsThe fruits of the santol tree are largely consumed in Asia and different parts of the plant (Sandoricum koetjape Merr.) are used in traditional medicine. Diverse bioactive terpenoids have been isolated from the plant. Their pharmacological properties are reviewed here, with a focus on the triterpene koetjapic acid which displays marked anti-inflammatory and anticancer properties. Several other bioactive natural products, including limonoids and flavonoids, are evoked as well, to shed light on the many active compounds found in the fruits and the whole plant. For a healthy life, How to cite this article: Bailly, C. ( 2022). The health benefits of santol fruits and bioactive products isolated from

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Four limonoids from the seeds extract of Sandoricum koetjape

Cited by 8 publications

References 18 publications

Antibacterial activity of Sentul fruit peel extract (Sandoricum koetjape) against Streptococcus mutans and Staphylococcus aureus

Antibacterial activity of Sentul fruit peel extract (Sandoricum koetjape) against Streptococcus mutans and Staphylococcus aureus

Research progress of meliaceous limonoids from 2011 to 2021

The health benefits of santol fruits and bioactive products isolated from Sandoricum koetjape Merr.: A scoping review

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