Four New Diterpene Glucosides from Perovskia atriplicifolia

Abstract

Four new diterpene glucosides, namely perovskiaditerpenosides A - D (1 - 4), were isolated from the BuOH extract of Perovskia atriplicifolia. Their structures were well elucidated by chemical methods and comprehensive spectroscopic analyses including MS, IR, and NMR (1D and 2D). The newly isolated compounds were screened for their cytotoxic activity against HepG2, NB4, HeLa, K562, MCF7, PC3, and HL60. The obtained results indicated that the new compounds possessed considerable cytotoxic activity.

Metabolomics and DNA-Based Authentication of Two Traditional Asian Medicinal and Aromatic Species of Salvia subg. Perovskia

“…Drew (formerly Perovskia atriplicifolia Benth. ), are distributed over vast areas from Western Iran and Pakistan and as far as Tibet and Xinjiang, in China [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 ].…”

“…In Uzbekistan and Kyrgyzstan, the aboveground parts are used to heal wounds, and a decoction is used to treat scabies [ 17 ]. In traditional Tibetan and Chinese medicine, it has been claimed that S. yangii is a powerful analgesic and parasiticide agent [ 9 , 24 ].…”

“…The research performed to date on plants of subgenus Perovskia concentrated on either roots [ 25 , 44 ] or aerial parts [ 7 , 49 , 50 , 51 ]. There are also reports on phytochemical analysis of the air-dried whole plants [ 2 , 3 , 4 , 9 , 24 , 52 ]. Plants were collected from their natural habitat or were cultivated.…”

Seasonal Variations of Rosmarinic Acid and Its Glucoside and Expression of Genes Related to Their Biosynthesis in Two Medicinal and Aromatic Species of Salvia subg. Perovskia

“…S. yangii is used as a cooling medicine in the treatment of fever, dysentery, scabies, diabetes, to heal wounds and as an antibacterial remedy [ 36 , 37 , 38 , 39 , 40 ]. In traditional Tibetan and Chinese medicine, it has been claimed that S. yangii is a powerful analgesic and parasiticide agent [ 41 , 42 ]. S. abrotanoides , with the common Persian name of “Brazambol,” is locally used for the treatment of typhoid, fever, headache, toothache, gonorrhoea, vomiting, cardiovascular diseases, liver fibrosis, painful urination and cough and as a sedative, analgesic and antiseptic drug [ 37 , 43 , 44 , 45 , 46 ].…”

Variations in Essential Oil Composition and Antioxidant Activity in Perovskia abrotanoides Kar. Collected from Different Regions in Iran

“…Caspian Perovskia is known for its essential oil that has found a variety of applications in traditional and folk medicine due to its antipyretic, antidiabetic, antiparasitic, and analgesic activities. To these may be added the leishmanicidal and antiplasmodial activities reported elsewhere …”