Four new diterpenoid alkaloids with anti-inflammatory activities from Aconitum taronense Fletcher et Lauener

Yin, Tianpeng; Hu, Xiaofang; Mei, Rui-Feng; Shu, Yan; Gan, Dong; Cai, Le; Ding, Zhong‐Tao

doi:10.1016/j.phytol.2018.04.001

Cited by 20 publications

(10 citation statements)

References 16 publications

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“…In the last few years, many plant active compounds with antioxidant and anti-inflammatory activities have been shown to exert potential clinical applications for the treatment of the chronic inflammatory bowel syndrome (IBS) [ 9 , 40 , 41 , 42 , 43 , 44 , 45 , 46 ]. IBS refers to several chronic inflammatory disorders of the gastrointestinal tract triggered by the action of environmental factors in genetically predisposed individuals [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

Fermented Portulaca oleracea L. Juice: A Novel Functional Beverage with Potential Ameliorating Effects on the Intestinal Inflammation and Epithelial Injury

et al. 2019

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P. oleracea L. contains high level of nutrients and biologically active compounds. Recently, lactic fermentation has been proposed as a biotechnological option to enrich the profile of biogenic compounds of Portulaca oleracea L. puree. This study investigated the capability of fermentation by selected lactic acid bacteria to enhance the restoring features of Portulaca oleracea juice towards intestinal inflammation and epithelial injury. Lactic acid fermentation markedly increased the total antioxidant capacity of P. oleracea juice, preserved the inherent levels of vitamins C, A, and E, and increased the bioavailability of the level of vitamin B2 and that of phenolics. The effects of fermented P. oleracea juice on a Caco-2 cell line were investigated using an in vitro model closest to the in vivo conditions. Fermented P. oleracea juice strongly decreased the levels of pro-inflammatory mediators and reactive oxygen species. It also counteracted the disruption of the Caco-2 cell monolayers treated with the inflammatory stimulus. We used a diversified spectrum of lactic acid bacteria species, and some effects appeared to be strains- or species-specific. Fermentation with Lactobacillus kunkeei B7 ensured the best combination for the content of bioactive compounds and the ability to counteract the intestinal inflammation and epithelial injury.

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Section: Discussionmentioning

confidence: 99%

Fermented Portulaca oleracea L. Juice: A Novel Functional Beverage with Potential Ameliorating Effects on the Intestinal Inflammation and Epithelial Injury

et al. 2019

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“…Almost all of the C 20 -diterpenoid alkaloids contain oxygenated groups. However, in contrast to the C 19 -diterpenoid alkaloids, C 20 -DAs possess the following distinctive features [ 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 , 136 , 137 , 138 , 139 , 140 , 141 , 142 , 143 , 144 , 145 , 146 , 147 , 148 , 149 , 150 , 151 , 152 , 153 , 154 , 155 , 156 , 157 ]: Most of them do not contain a methoxy group in their structures as C 19 -DAs [ 108 ]; Some alkaloids contain an acetoxy group or benzoyloxy ester group, or both, and do not incl...…”

Section: Classification Of Diterpenoid Alkaloidsmentioning

confidence: 99%

Classification, Toxicity and Bioactivity of Natural Diterpenoid Alkaloids

Thawabteh

Lelario

et al. 2021

Molecules

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Diterpenoid alkaloids are natural compounds having complex structural features with many stereo-centres originating from the amination of natural tetracyclic diterpenes and produced primarily from plants in the Aconitum, Delphinium, Consolida genera. Corals, Xenia, Okinawan/Clavularia, Alcyonacea (soft corals) and marine sponges are rich sources of diterpenoids, despite the difficulty to access them and the lack of availability. Researchers have long been concerned with the potential beneficial or harmful effects of diterpenoid alkaloids due to their structural complexity, which accounts for their use as pharmaceuticals as well as their lousy reputation as toxic substances. Compounds belonging to this unique and fascinating family of natural products exhibit a broad spectrum of biological activities. Some of these compounds are on the list of clinical drugs, while others act as incredibly potent neurotoxins. Despite numerous attempts to prepare synthetic products, this review only introduces the natural diterpenoid alkaloids, describing ‘compounds’ structures and classifications and their toxicity and bioactivity. The purpose of the review is to highlight some existing relationships between the presence of substituents in the structure of such molecules and their recognised bioactivity.

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“…In addition to the genera Aconitum and Consolida, Delphinium is a genus in the Ranunculaceae family that is well known for its characteristic DA components. 16,17 DAs are clearly the major constituents of Delphinium plants, and most of the published articles are devoted to DA components. In the past forty years, a large number of biologically active and structurally complex DAs have been isolated from various species of Delphinium.…”

Section: Alkaloidsmentioning

confidence: 99%

“…13). Generally, vakognavine-type C 20 -DAs seldom have a C (15) ]C (16) bond, but anthriscifolmines G (393) and H (392) from D. anthriscifolium var. savatieri are exceptions to this statement.…”

Section: -Diterpenoid Alkaloidsmentioning

confidence: 99%

An overview of the chemical constituents from the genus Delphinium reported in the last four decades

2020

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Four new diterpenoid alkaloids with anti-inflammatory activities from Aconitum taronense Fletcher et Lauener

Cited by 20 publications

References 16 publications

Fermented Portulaca oleracea L. Juice: A Novel Functional Beverage with Potential Ameliorating Effects on the Intestinal Inflammation and Epithelial Injury

Fermented Portulaca oleracea L. Juice: A Novel Functional Beverage with Potential Ameliorating Effects on the Intestinal Inflammation and Epithelial Injury

Classification, Toxicity and Bioactivity of Natural Diterpenoid Alkaloids

An overview of the chemical constituents from the genus Delphinium reported in the last four decades

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