Four new minor brominated indole related alkaloids with antibacterial activities from Laurencia similis

Marine natural products

“…371 Halogenated indoles are another commonly encountered structural type, with eleven polyhalogenated indoles 772-782 from Rhodophyllis membranacea, including six which were the rst isolation of bromo-chloro-iodo secondary metabolites, as exemplied by 776. 372 Further related compounds were four brominated indole related alkaloids 783-786 (Laurencia similis), 373 and bromophenol 787 (Odonthalia corymbifera). 374 Papers describing work on new bioactivities for known compounds from red algae include the reporting of the larvicidal potential of obtusol (Laurencia dendroidea) 375 against the dengue fever mosquito Aedes aegypti, 376 bis(2,3-dibromo-4,5dihydroxybenzyl) ether (BDDE) (Odonthalia corymbifera) 377 as a novel PTP1B inhibitor and potential anti-diabetic agent, 378 immunomodulatory effects of the mycosporine-like amino acids shinorine and porphyra-334 from Porphyra sp., 379 and the insecticidal activity guided isolation of palytoxin 380 from Chondria armata.…”

Marine Alkaloids with Anti-Inflammatory Activity: Current Knowledge and Future Perspectives

“…An azocinyl morpholinone alkaloid (42) extracted from Gracilaria opuntia showed anti-inflammatory activity in a murine model of carrageenan-induced paw edema, reducing edema formation by 6 h and exhibiting a selective inhibitory effect on COX-2 and 5-LOX activity [106]. Other red algae of the genus Laurencia are also sources of alkaloids with known biological activities and already elucidated antimicrobial potential [107][108][109]. On the other hand, a methanol/dichloromethane extract of Laurencia obtusa showed an anti-inflammatory effect on LPS-stimulated THP-1 cells, reducing TNF-α production by these cells, and decreased in vivo the inflammatory exudate in a murine model of carrageenan-induced paw edema [110].…”

Generation of Indoles with Agrochemical Significance through Biotransformation by Chaetomium globosum

“…The indole structure motif occurs in a variety of natural products as well as in synthetic agrochemicals. This motif is associated with a broad spectrum of biological profiles ranging from antifungal and antibacterial to nematicidal activities. − Some indole-bearing pesticides such as amisulbrom and indole-3-acetic acid (a well-known plant hormone) have sparked numerous synthetic efforts to access new alkaloids with such indole-related substructure(s). , Unlike the synthetic approaches, this work describes the application of an endophytic fungus for biotransformation of 1-MT to produce new indole alkaloids, some of which were shown to have promising antifungal and antibacterial activities. Collectively, this work provides an efficient and environmentally benign methodology for constructing structurally undescribed indoles, from which lead molecules can be recognized and optimized for new pesticide development.…”