Four New Sesquiterpenoids from <i>Zanthoxylum nitidum</i>

Feng, Qicheng; Li, Mei‐Shan; Li, Jinjun; Wang, Yue; Wang, Ke; Zhou, Jian‐Yu; Liang, Dong; Wang, Hengshan

doi:10.1002/cbdv.202200449

Cited by 4 publications

(1 citation statement)

References 14 publications

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“…The roots ofZanthoxylum nitidum (ZN) are a type of tea in southern China, which can be used to relieve neuralgia and headache . In recent years, with the aging in the Chinese population, many diseases such as hypertension, hyperglycemia, hyperlipidemia, and Alzheimer’s disease are common in the elderly. , Zanthoxyli radix is becoming increasingly popular among the elderly population.…”

Section: Introductionmentioning

confidence: 99%

Integration of High-Resolution LC-Q-TOF Mass Spectrometry and Multidimensional Chemical−Biological Analysis to Detect Nanomolar-Level Acetylcholinesterase Inhibitors from Different Parts of Zanthoxylum nitidum

Zhang,

Pei,

Wang

et al. 2024

J. Agric. Food Chem.

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Zanthoxyli radix is a popular tea among the elderly, and it is believed to have a positive effect on Alzheimer's disease. In this study, a highly effective three-step strategy was proposed for comprehensive analysis of the active components and biological functions of Zanthoxylum nitidum (ZN), including high-resolution LC-Q-TOF mass spectrometry (HRMS), multivariate statistical analysis for heterogeneity (MSAH), and experimental and virtual screening for bioactivity analysis (EVBA). A total of 117 compounds were identified from the root, stem, and leaf of ZN through HRMS. Bioactivity assays showed that the order of acetylcholinesterase (AChE) inhibitory activity from strong to weak was root > stem > leaf. Nitidine, chelerythrine, and sanguinarine were found to be the main differential components of root, stem, and leaf by OPLS-DA. The IC 50 values of the three compounds are 0.81 ± 0.02, 0.14 ± 0.01, and 0.48 ± 0.01 μM respectively, indicating that they are potent and high-quality AChE inhibitors. Molecular docking showed that pi-pi T-shaped interactions and pi-lone pairs played important roles in AChE inhibition. This study not only explains the biological function of Zanthoxyli radix in alleviating Alzheimer's disease to some extent, but also lays the foundation for the development of stem and leaf of ZN.

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Section: Introductionmentioning

confidence: 99%

Integration of High-Resolution LC-Q-TOF Mass Spectrometry and Multidimensional Chemical−Biological Analysis to Detect Nanomolar-Level Acetylcholinesterase Inhibitors from Different Parts of Zanthoxylum nitidum

Zhang,

Pei,

Wang

et al. 2024

J. Agric. Food Chem.

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Terpenoids from the rhizomes of Curcuma kwangsiensis S.G. Lee et C.F. Ling and their anti-inflammatory activities

Zhang,

Xu,

Sun

et al. 2024

Fitoterapia

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SSR molecular marker developments and genetic diversity analysis of Zanthoxylum nitidum (Roxb.) DC

Zhu,

Ma,

Lin

et al. 2023

Sci Rep

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Zanthoxylum nitidum (Roxb.) is a commonly used traditional Chinese medicine. However, the collection and protection of wild germplasm resources of Z. nitidum are still insufficient, and there is limited research on its genetic diversity and fingerprint. In the present study, 15 simple sequence repeat (SSR) markers were developed by genotyping based on multiplexed shotgun sequencing. The genetic diversity of 51 populations (142 individuals) of Z. nitidum was evaluated using these 15 SSRs. A total of 245 alleles (Na) were detected, with an average value of 16.333, and the average polymorphism information content was 0.756. The genetic distance among 51 populations was 0.164~1.000, with an average of 0.659. Analysis of molecular variance showed low genetic differentiation (40%) and high genetic differentiation (60%) between populations and individuals, respectively. The genetic differentiation coefficient (Fst) of the population was 0.338, indicating that 66.2% of the genetic variation occurred within the population, and the gene flow (Nm) was 0.636, demonstrating that the gene exchange between populations was low. Clustering analysis revealed that the genetic similarity coefficient was 0.30, dividing the 51 populations into 4 groups of 2, 17, 3, and 29 populations. There was no specific relationship between geographical location differences and genetic distance. The genetic diversity level of Z. nitidum is relatively high, and our results provide a theoretical basis for the rapid identification of Z. nitidum germplasm resources and variety selection.

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Four New Sesquiterpenoids from Zanthoxylum nitidum

Cited by 4 publications

References 14 publications

Integration of High-Resolution LC-Q-TOF Mass Spectrometry and Multidimensional Chemical−Biological Analysis to Detect Nanomolar-Level Acetylcholinesterase Inhibitors from Different Parts of Zanthoxylum nitidum

Integration of High-Resolution LC-Q-TOF Mass Spectrometry and Multidimensional Chemical−Biological Analysis to Detect Nanomolar-Level Acetylcholinesterase Inhibitors from Different Parts of Zanthoxylum nitidum

Terpenoids from the rhizomes of Curcuma kwangsiensis S.G. Lee et C.F. Ling and their anti-inflammatory activities

SSR molecular marker developments and genetic diversity analysis of Zanthoxylum nitidum (Roxb.) DC

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