Four pairs of neolignan enantiomers with distinctive isochroman moiety from the fruits of Crataegus pinnatifida and their protective activities against H2O2-induced SH-SY5Y cells

Zhao, Peng; Li, Shi-Fang; Hou, Jiao-Yang; Qin, Shu-Yan; Li, Jia-Yi; Zhou, Xiao-Fang; Liu, Xuan; Hao, Jin-Le; Lin, Bin; Huang, Xiao-Xiao; Song, Shao-Jiang

doi:10.1016/j.phytochem.2023.113933

Cited by 2 publications

(1 citation statement)

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“…Analysis of the calculated and experimental 13 C NMR data revealed that the relative configuration of 1 was 2″S,3″S with a DP4+ probability of 99.88% (Figure 5 and Tables S2−S11). 39 At the same time, the calculated data of the two isomers (2″S,3″S) and (2″R,3″R) and the experimental 13 C NMR chemical shifts of compound 1 were subjected to regression analysis. Among them, the structure (2″S,3″S) showed a better matching value of R 2 of 0.9986 (Figure 5).…”

Section: ■ Introductionmentioning

confidence: 99%

Natural Prenylflavonoids from Sophora flavescens Root Bark against Multidrug-Resistant Methicillin-Sensitive Staphylococcus aureus Targeting the Membrane Permeability

Li,

Gao,

Wang

et al. 2024

J. Agric. Food Chem.

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The overuse of antibiotics in animal farming and aquaculture has led to multidrug-resistant methicillin-sensitive Staphylococcus aureus (MR-MSSA) becoming a common pathogen in foodborne diseases. Sophora flavescens Ait. serves as a traditional plant antibacterial agent and functional food ingredient. A total of 30 compounds (1−30) were isolated from the root bark of S. flavescens, consisting of 20 new compounds (1−20). In the biological activity assay, compound 1 demonstrated a remarkable inhibitory effect on MR-MSSA, with an MIC of 2 μg/mL. Furthermore, 1 was found to rapidly eliminate bacteria, inhibit biofilm growth, and exhibit exceptionally low cytotoxicity. Mechanistic studies have revealed that 1 possesses an enhanced membrane-targeting ability, binding to the bacterial cell membrane components phosphatidylglycerol (PG), phosphatidylethanolamine (PE), and cardiolipin (CL). This disruption of bacterial cell membrane integrity increases intracellular reactive oxygen species, protein and DNA leakage, reduced bacterial metabolism, and ultimately bacterial death. In summary, these findings suggest that compound 1 holds promise as a lead compound against MR-MSSA.

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Section: ■ Introductionmentioning

confidence: 99%