Four Pistacia atlantica subspecies (atlantica, cabulica, kurdica and mutica): A review of their botany, ethnobotany, phytochemistry and pharmacology

Ahmed, Ziyad Ben; Yousfi, Mohamed; Viaene, Johan; Dejaegher, Bieke; Demeyer, Kristiaan; Heyden, Yvan Vander

doi:10.1016/j.jep.2020.113329

Cited by 50 publications

(46 citation statements)

References 98 publications

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“…Traditionally, the plant parts were employed for therapeutic purposes due to their healing potentials [26], such as stomach aches, indigestion, throat infections, and peptic ulcers, a repellent of insects, against chest diseases, expectorant, and anti-asthma [27]. Previous researchers have described various biological activities for different P. atlantica extracts: antimicrobial, antifungal, antiviral, antiplasmodial and antileishmanial [28]. Different parts of P. atlantica have been investigated for various phytochemical studies.…”

Section: Leishmania Majormentioning

confidence: 99%

3-Methoxycarpachromene and Masticadienonic Acid as New Target Inhibitors from <em>Pistacia atlantica </em>Leaves against Trypanothione Reductase of Leishmania Parasites: In Vitro and In Silico Studies

Maamri¹,

Benarous²,

Yousfi³

2021

Preprint

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This study aimed to identify new drug molecules against Leishmania parasites, leishmaniasis's causal agent, using Pistacia atlantica leaves as source. The evaluation of the anti-leishmania potential against the promastigote form of Leishmania. infantum and Leishmania. major was performed. A new in silico study was accomplished using molecular docking, with Autodock vina program, to find the binding affinity of two important phytochemical compounds from this plant (Masticadienonic acid, 3-Methoxycarpachromene) towards the trypanothione reductase as target drugs, responsible for defence mechanism against oxidative stress and virulence of this parasites. Results: Several concentrations showed a significant decrease in cell viability (P<0.0001), with IC50 values of 0.3 mg/ mL for L. infantum and 0.12 mg/ mL L. major; The molecular docking confirms the significant relationship between Leishmania survival and the inhibition of this crucial enzyme. There were promising and new positive results on binding modes of selected ligands and the trypanothione reductase for the first time. Through this work, we propose 3-Methoxycarpachromene and Masticadienonic acid as anti Trypanosomatidae species drug.

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Section: Leishmania Majormentioning

confidence: 99%

3-Methoxycarpachromene and Masticadienonic Acid as New Target Inhibitors from <em>Pistacia atlantica </em>Leaves against Trypanothione Reductase of Leishmania Parasites: In Vitro and In Silico Studies

Maamri¹,

Benarous²,

Yousfi³

2021

Preprint

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“…In addition, P. lenticus, P. atlantica, P. palaestina, and P. vera, among others exhibited anticancer activity in numerous experimental studies. In this context, the crude extract of leaves and fruits of P. lenticus substantially suppressed the growth in the cell line of the growing melanoma [10], where inhibitory potential against BHK21 cell line has been identified in the seed oil of P. lenticus [11]. Furthermore, the ethanol extract of P. atlantica showed significant activity against gastric and cervical carcinoma [12].…”

Section: Introductionmentioning

confidence: 99%

Pharmacological Investigation of Genus Pistacia

Rauf¹,

Al-Awthan²,

Muhammad³

et al. 2022

Natural Medicinal Plants

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Several plants in the genus Pistacia are used in the treatment of various pathogenic and non-pathogenic disorders. Especially important are the major species belonging to this genus such as Pistacia lentiscus, Pistacia atlantica, Pistacia vera, Pistacia terebinthus, and Pistacia khinjuk, among others; these have been reported for their potential benefits both in medical and commercial purposes. In addition, members of this genus exhibit numerous ethnomedicinal uses, such as analgesic, anti-inflammatory, anticancer, antimicrobial, antihypertension, antihyperlipidemic, antiviral, and antiasthma. In light of these potential uses, the present chapter aimed to collect and summarize the literature about all of this medicinal information. Accordingly, this chapter focuses on the pharmacological uses and benefits of the genus Pistacia, especially those related to health issues.

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“…The genus Pistacia, Anacardiaceae family consists of at least 11 dioecious species [1], four of these being found in North Africa, including Algeria (Pistacia vera L., P. terebinthus L., P. lentiscus L., and P. atlantica Desf.). Pistachio (P. vera L.) is known for its economic value in agriculture as a nut crop [2][3][4]. The other three species possess ecological importance in addition to their use as medicinal plants and sources of feed for animals and birds [4].…”

Section: Introductionmentioning

confidence: 99%

“…Pistachio (P. vera L.) is known for its economic value in agriculture as a nut crop [2][3][4]. The other three species possess ecological importance in addition to their use as medicinal plants and sources of feed for animals and birds [4]. The Atlas pistachio (P. atlantica Desf.)…”

Section: Introductionmentioning

confidence: 99%

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Genetic Variation in Damaged Populations of Pistacia atlantica Desf.

Labdelli

Herrán

Arafeh

et al. 2020

Plants

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The Atlas Pistachio tree, Pistacia atlantica Desf., has great importance in the ecological landscape of North Africa, due to its adaptive plasticity, as well as its use as a rootstock in the cultivation of the economically important species, Pistacia vera L. The conservation and valuation of this species require sampling and an assessment of its genetic variability. For the first time in North Africa, the inter-simple sequence repeats (ISSR) molecular marker has been used in genetic-diversity assessment and in the population relationships of P. atlantica subsp. atlantica. The ISSR markers tested showed 74.1% polymorphism, while molecular variance (AMOVA) analysis revealed a high percentage of the total genetic diversity of 55.7% among the four populations studied. Cluster analysis with neighbor-joining (NJ) and principal coordinate analysis (PCO) divided the study sites into four distinct groups according to their geographical locations (Tiaret, Batna, Djelfa, and Bechar). Isolation by distance or Mantel test gave a positive correlation of r = 0.86 between geographical and genetic distances. The results in this study indicate an absence of gene flow, implying that conservation efforts should be taken separately for each population.

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Four Pistacia atlantica subspecies (atlantica, cabulica, kurdica and mutica): A review of their botany, ethnobotany, phytochemistry and pharmacology

Cited by 50 publications

References 98 publications

3-Methoxycarpachromene and Masticadienonic Acid as New Target Inhibitors from <em>Pistacia atlantica </em>Leaves against Trypanothione Reductase of Leishmania Parasites: In Vitro and In Silico Studies

3-Methoxycarpachromene and Masticadienonic Acid as New Target Inhibitors from <em>Pistacia atlantica </em>Leaves against Trypanothione Reductase of Leishmania Parasites: In Vitro and In Silico Studies

Pharmacological Investigation of Genus Pistacia

Genetic Variation in Damaged Populations of Pistacia atlantica Desf.

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