Fourier Analysis Reveals Increased Trabecular Spacing in Sickle Cell                Anemia

Faber, T.; Yoon, D C; White, Stuart C.

doi:10.1177/0810214

Cited by 10 publications

(9 citation statements)

References 19 publications

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“…It was suggested that hyperplasia of the marrow may cause trabecular destruction. Faber et al [22] showed that chronic anemia causes increase in trabecular spacing, which leads to trabecular destruction, which in turn causes osteopenia or osteoporosis. It was reported that in patients with Hbβ-thalassemia, osteopenia and osteoporosis occur due to marrow expansion.…”

Section: Discussionmentioning

confidence: 99%

Secondary osteoporosis due to sickle cell anemia: Do sex steroids play a role?

et al. 2008

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Section: Discussionmentioning

confidence: 99%

Secondary osteoporosis due to sickle cell anemia: Do sex steroids play a role?

et al. 2008

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“…It is hypothesized that overexertion of hematopoiesis provokes bone marrow hyperplasia and reduces the amount of bone generated [1], causing bone distortion/fragility and enhanced bone resorption [2]. This hypothesis is sustained by the fact that low BMD is found in mice bled chronically for 10 months or in total-body irradiated mice [3].…”

Section: Introductionmentioning

confidence: 99%

Alterations in Bone and Erythropoiesis in Hemolytic Anemia: Comparative Study in Bled, Phenylhydrazine-Treated and Plasmodium-Infected Mice

et al. 2012

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Sustained erythropoiesis and concurrent bone marrow hyperplasia are proposed to be responsible for low bone mass density (BMD) in chronic hemolytic pathologies. As impaired erythropoiesis is also frequent in these conditions, we hypothesized that free heme may alter marrow and bone physiology in these disorders. Bone status and bone marrow erythropoiesis were studied in mice with hemolytic anemia (HA) induced by phenylhydrazine (PHZ) or Plasmodium infection and in bled mice. All treatments resulted in lower hemoglobin concentrations, enhanced erythropoiesis in the spleen and reticulocytosis. The anemia was severe in mice with acute hemolysis, which also had elevated levels of free heme and ROS. No major changes in cellularity and erythroid cell numbers occurred in the bone marrow of bled mice, which generated higher numbers of erythroid blast forming units (BFU-E) in response to erythropoietin. In contrast, low numbers of bone marrow erythroid precursors and BFU-E and low concentrations of bone remodelling markers were measured in mice with HA, which also had blunted osteoclastogenesis, in opposition to its enhancement in bled mice. The alterations in bone metabolism were accompanied by reduced trabecular bone volume, enhanced trabecular spacing and lower trabecular numbers in mice with HA. Taken together our data suggests that hemolysis exerts distinct effects to bleeding in the marrow and bone and may contribute to osteoporosis through a mechanism independent of the erythropoietic stress.

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“…We compute the discrete Fourier transform of each of these samples (figure 4 c ), average the spectra (figure 4 d ) and calculate the ratio metric (figure 4 e ). As in Faber et al [27], the ratio metric is defined as the base-10 logarithm of the ratio of average signal intensity in the low-frequency band to the average intensity in the high-frequency band.…”

Section: Resultsmentioning

confidence: 99%

“…In Faber et al [27], the frequency bands corresponded to short and wide Tb.Sp ranges. In our case, we fix the band widths and locations to coincide roughly with Tb.Sp and Tb.Th distributions (of non-eroded structure) as determined with histomorphometric analysis in CTAn.…”

Section: Resultsmentioning

confidence: 99%

Novel magnetic resonance technique for characterizing mesoscale structure of trabecular bone

Nguyen

Schlesinger

James³

et al. 2018

R. Soc. open sci.

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Osteoporosis, characterized by increased fracture risk and bone fragility, impacts millions of adults worldwide, but effective, non-invasive and easily accessible diagnostic tests of the disease remain elusive. We present a magnetic resonance (MR) technique that overcomes the motion limitations of traditional MR imaging to acquire high-resolution frequency-domain data to characterize the texture of biological tissues. This technique does not involve obtaining full two-dimensional or three-dimensional images, but can probe scales down to the order of 40 μm and in particular uncover structural information in trabecular bone. Using micro-computed tomography data of vertebral trabecular bone, we computationally validate this MR technique by simulating MR measurements of a ‘ratio metric’ determined from a few k-space values corresponding to trabecular thickness and spacing. We train a support vector machine classifier on ratio metric values determined from healthy and simulated osteoporotic bone data, which we use to accurately classify osteoporotic bone.

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Fourier Analysis Reveals Increased Trabecular Spacing in Sickle Cell Anemia

Cited by 10 publications

References 19 publications

Secondary osteoporosis due to sickle cell anemia: Do sex steroids play a role?

Secondary osteoporosis due to sickle cell anemia: Do sex steroids play a role?

Alterations in Bone and Erythropoiesis in Hemolytic Anemia: Comparative Study in Bled, Phenylhydrazine-Treated and Plasmodium-Infected Mice

Novel magnetic resonance technique for characterizing mesoscale structure of trabecular bone

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